Results 91 to 100 of about 2,341,685 (286)

Engineered Transformer Base Editor with Enhanced Editing Efficiency

Advanced Science, EarlyView.
A highly efficient transformer base editor system achieves robust genomic editing in a humanized mouse model. This work establishes a versatile and translatable platform, opening new avenues for precision gene therapy. ABSTRACT Canonical cytosine base editors (CBEs) achieve precise C‐to‐T conversions without inducing DNA double‐strand breaks (DSBs ...
Bowen Chen, Letong Liang, Rui Xu, Tianyi Wang, Hongyan Chen, Daru Lu   +5 more
wiley   +1 more source

Software quality and governance in agile software development

, 2009
Looking at software engineering from a historical perspective, we can see how software development methodologies have evolved over the past 50 years. Using the right software development methodology with the right settings has always been a challenge ...
Abbas, Noura
core   +1 more source

Spectral control of a cavity-based x-ray free-electron laser via active mode locking

Physical Review Research
Precise spectral control in the hard x-ray regime remains a long-standing challenge that limits applications in atomic-scale science and ultrafast spectroscopy.
Nanshun Huang, Hanxiang Yang, Haixiao Deng   +2 more
doaj   +1 more source

CRISPR and Gene Augmentation Rescue Trabecular Meshwork Dysfunction in iPSC Models of Lowe Syndrome

Advanced Science, EarlyView.
By modeling Lowe syndrome using patient‐derived iPSCs, this study establishes a human disease model that faithfully recapitulates OCRL deficiency‐associated ciliary and cytoskeletal defects. The model enables evaluation of both mutation‐agnostic DNA augmentation and CRISPR‐mediated mutation correction strategies, both of which restore OCRL function and
Siyu Chen, Zhiquan Liu, Wenmin Wang, Qing Wang, Tia J. Kowal, Fan Zhang, Grzegorz Walkiewicz, Faruk Hossen, Herbert M. Lachman, Jinqiong Zhou, Yiting Wang, Yang Sun   +11 more
wiley   +1 more source

An Integrated Model for the Design of Agile Supply Chains [PDF]

, 2001
The latter part of the 20th Century saw the lean production paradigm positively impact many market sectors ranging from automotive through to construction.
Towill, Denis R., Christopher, Martin
core   +1 more source

Cross‐scale Material‐Structure Synergy for 2D Metamaterials: Toward Customizable Intelligent Electromagnetic Manipulation in Multiphysics Fields

Advanced Science, EarlyView.
Recent advances in metasurface‐enabled low‐observable technologies are reviewed from the perspective of cross‐scale material–structure synergy. Electromagnetic, thermal, optical, and acoustic stealth are highlighted together with dynamic tuning, programmable coding, data‐driven inverse design, artificial intelligence, multispectral compatibility, and ...
Shuhao Wang, Xing Yang, Liping Liu, Yang Peng, Yangyang Wang, Hualiang Lv   +5 more
wiley   +1 more source

An overview of Agile Organizations, with a focus on Agile Leadership and Organizational Change. [PDF]

, 2022
openQuesto scritto offre una panoramica sulle organizzazioni Agili, analizzandone nel primo capitolo le caratteristiche chiave, la storia, e la sua diffusione attuale.
TENUCCI, LUIGI GIACOMO
core  

Closing the Loop: High‐Precision 3D Photofabrication in Living Tissues

Advanced Science, EarlyView.
Writing 3D microstructures inside living tissue demands more than laser access; It demands information. Hierarchical sensing captures thermal and mechanical states across pulse‐train, voxel, and structure timescales, feeding a controller that steers the laser in real time.
Amirbahador Zeynali, Mangirdas Malinauskas, Giuseppe Chirico   +2 more
wiley   +1 more source

Complex-mode-volume perturbation theory for frequency-agile terahertz sensors

Journal of Applied Physics
We derive a first-order perturbation formula that links the complex eigenfrequency shift of terahertz resonator-based sensors directly to its complex mode volume V~c. This closed-form expression simultaneously captures the resonance shift, the linewidth change, sensitivity, and figure of merit, and remains valid across a wide range of resonator types ...
Lei Cao, Yiming Zhang, Xiaochi Ma, Mingxuan Mao, Fanqi Meng   +4 more
openaire   +1 more source

Recent Advances in Programmable Metasurfaces and Meta‐Devices

Advanced Electronic Materials, EarlyView.
Programmable metasurfaces enable various novel functionalities by dynamically tuning electromagnetic wavefronts. This article provides a comprehensive review of recent advances in microwave and terahertz programmable metasurfaces, covering electrical, thermal, optical, and mechanical control mechanisms.
Linda Shao, Chong He, Nan Wang, Liming Si, Weiren Zhu   +4 more
wiley   +1 more source