Results 71 to 80 of about 1,130,542 (297)

The Contemporary Understanding of User Experience in Practice

, 2015
User Experience (UX) has been a buzzword in agile literature in recent years. However, often UX remains as a vague concept and it may be hard to understand the very nature of it in the context of agile software development.
Abrahamsson, Pekka, Hellweger, Stefan, Wang, Xiaofeng   +2 more
core   +2 more sources

A Review on Biodegradable Materials of Sustainable Soft Robotics and Electronics

Advanced Science, EarlyView.
Biodegradable materials are gaining increasing attention in soft robotics and electronics due to their environmental friendliness, showing great potential for sustainability. In this review, the classification of biodegradable materials, their applications in the field of soft robotics and electronics, as well as the challenges and future prospects ...
Yizhu Xie, Jiaxin Han, Xingyi Dai, Xuyang Zhang, Kangwen Xiao, Junhui Huang, Yajun Cao, Aihua Zhong, Long‐Biao Huang   +8 more
wiley   +1 more source

CoFeD: A visualisation framework for comparative quality evaluation [PDF]

, 2017
Evaluation for the purpose of selection can be a challenging task particularly when there is a plethora of choices available. Short-listing, comparisons and eventual choice(s) can be aided by visualisation techniques.
Comley , Richard, Georgiadou, Elli, White, Anthony   +2 more
core  

TRIM38 Suppresses Breast Cancer Progression via Modulating SQSTM1 Ubiquitination and Autophagic Flux

Advanced Science, EarlyView.
TRIM38, an E3 ubiquitin ligase, suppresses breast cancer progression by inhibiting proliferation, migration, and invasion. Downregulated in breast tumor, its loss correlates with poor prognosis. Mechanistically, TRIM38 mediates K63‐linked ubiquitination of SQSTM1/p62 at K420, disrupting SQSTM1‐LC3 interaction and blocking autophagic flux.
Shan Jiang, Lijuan Wang, Dianwen Han, Peng Su, Bing Chen, Wenjing Zhao, Tong Chen, Ning Zhang, Xiaolong Wang, Yiran Liang, Yaming Li, Chen Li, Xi Chen, Dan Luo, Qifeng Yang   +14 more
wiley   +1 more source

Cleavage‐Resistant CYLD Protects Against Autoimmune Hepatitis

Advanced Science, EarlyView.
Proteolytic cleavage of the deubiquitinase CYLD emerges as a critical driver of autoimmune hepatitis. TNFα‐induced CYLD loss in macrophages amplifies S100A9‐triggered MAPK activation, leading to excessive chemokine production and hepatic inflammation. Pharmacological inhibition of MEK signaling effectively attenuates experimental disease, highlighting ...
Han Liu, Chen Su, Jianling Liu, Mingyan Xing, Xiaoxia Wu, Lingxia Wang, Xiaoming Zhao, Hanwen Zhang, YangYang Xie, YangYang Wang, Hong Li, Yu Li, Ming Li, Haibing Zhang   +13 more
wiley   +1 more source

High‐Speed, Maneuverable, and Terrain‐Adaptive Micro‐Robot with Tree Frog‐Inspired Bionic Feet

Advanced Science, EarlyView.
A 7.5 mm micro‐robot integrates tree frog‐inspired bionic feet with an electromagnetic linear motor to achieve high‐speed locomotion, slope climbing, and precise turning. It reaches 39 body lengths per second and ascends 30° slopes. The system demonstrates strong potential for inspection tasks in confined and complex environments, such as micro‐aero ...
Weizhi Zhao, Shijia Li, Kaiwen Zhang, Wanyu Zhang, Danyang Liu, Weidong Fang, Yanxin Zhai, Kaibo Lei, Liwen Zhang, Huawei Chen, Tiantong Xu   +10 more
wiley   +1 more source

Advanced Human Immune Cell‐Organoid Co‐Cultures for Functional Testing of Cancer Nanovaccines

Advanced Science, EarlyView.
Pancreatic ductal adenocarcinoma remains difficult to treat. We establish an organoid–immune co‐culture using patient‐derived organoids and matched T‐cells to assess cancer vaccines. A mesothelin‐targeted nanovaccine activates antigen‐specific T‐cells, increases IFN‐γ, and targets MSLN+ organoids.
Nathalia Ferreira, David Agorku, Andre Rosa, Julia Roosz, Lena Christ, Nicole Anderle, Ajinkya Kulkarni, Abir Hussein, Sana S. Sayedipour, Omar F. Luna, Tobias Legler, Philipp Ströbel, Fernando Albericio, Luis Cruz, Phillipp Beckhove, Peter Loskill, Frauke Alves, M. Andrea Markus, Fernanda Ramos‐Gomes   +18 more
wiley   +1 more source

Structure‐Guided Engineering of a Cas12i Nuclease Unlocks Near‐PAMless Genome Editing

Advanced Science, EarlyView.
CRISPR‐Cas nucleases are limited by PAM requirements, restricting genome accessibility. Structure‐guided engineering of the compact Cas12i nuclease SF01 produced three variants with near‐PAMless, enabling efficient editing at diverse 5'‐NNTN‐3' sites. These nucleases expand the editable portion of the human genome more than fourfold, enabling efficient
Qitong Chen, Hanlin Gou, Chao Xu, Sihan Wang, Huitao Zhang, Minglei Song, Mengge Wang, Xingkun Ji, Xiaofei Wei, Yuanyan Tan, Hehua Quan, Pengyu Luo, Hanyu Shou, Pengpeng Liu, Yafeng Liang, Jian‐Kang Zhu   +15 more
wiley   +1 more source

Using DevOps Toolchains in Agile Model-Driven Engineering [PDF]

, 2021
Jörn Guy Süß, Samantha Swift, Eban Escott   +2 more
openalex   +1 more source

Biomimetic Multiscale‐Structured Biomass Graphene/Polyurethane Sponge Composite for Flexible Pressure Sensors and Intelligent Cushioning Materials

Advanced Science, EarlyView.
In this study, a multifunctional conductive sponge composite (MAPU) is developed using a biomimetic, hierarchical construction strategy emulating the growth process of natural wood. This approach involved integrating biomass‐derived graphitic nanoflakes, synthesized from luffa vine (LVGN), into a polyurethane (PU) sponge matrix.
Runmin Xu, Pusen Cao, Tingting Zhang, Jie Wei, Yue Wang, Zhi Huang, Zhenghang Chen, Jianfeng Xi, Yong Guo, Yuxia Chen   +9 more
wiley   +1 more source