Results 101 to 110 of about 2,808,990 (283)

Single Molecule Analysis of Laser Localized Interstrand Crosslinks

Frontiers in Genetics, 2016
DNA interstrand crosslinks (ICLs) block unwinding of the double helix, and have always been regarded as major challenges to replication and transcription. Compounds that form these lesions are very toxic and are frequently used in cancer chemotherapy. We
Jing eHuang, Himabindu eGali, Manikandan eParamasivam, Parameswary eMuniandy, Julia eGichimu, Marina Andrea Bellani, Michael M Seidman   +6 more
doaj   +1 more source

Paraneoplastic Lupus Nephritis in a Child With Neuroblastoma Recurrence

Pediatric Blood &Cancer, EarlyView.
Gabriele Mortari, Caterina Costagliola, Marta Nebiolo, Francesca Parisi, Martina Morini, Katia Mazzocco, Gabriele Gaggero, Stefano Volpi, Stefania Sorrentino, Virginia Livellara   +9 more
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Frailty assessment in geriatric trauma patients: comparing the predictive value of the full and a condensed version of the Fried frailty phenotype

BMC Geriatrics
Background Frailty is associated with multiple negative outcomes in geriatric trauma patients. Simultaneously, frailty assessment including physical measurements for weakness (grip strength) and slowness (gait speed) poses challenges in this vulnerable ...
Joninah Braunschweig, Wei Lang, Gregor Freystätter, Christian Hierholzer, Heike A. Bischoff-Ferrari, Michael Gagesch   +5 more
doaj   +1 more source

Physiology and pathology of calcium signaling in the brain

Frontiers in Pharmacology, 2012
Calcium (Ca2+) plays fundamental and diversified roles in neuronal plasticity. As second messenger of many signaling pathways, Ca2+ as been shown to regulate neuronal gene expression, energy production, membrane excitability, synaptogenesis, synaptic ...
Elisa Mitikp Kawamoto, Carmen eVivar, Simonetta eCamandola   +2 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Circuit training intervention for cognitive function, gut microbiota, and aging control: study protocol for a longitudinal, open-label randomized controlled trial

Trials
Background Long-term exercise is increasingly considered an effective strategy to counteract cognitive decline associated with aging. Previous studies have indicated that circuit training exercises integrating aerobic and resistance modalities positively
Keishi Soga, Michio Takahashi, Akari Uno, Takamitsu Sinada, Kentaro Oba, Keisei Kawashima, Yasuko Tatewaki, Taizen Nakase, Yasuyuki Taki   +8 more
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Aging in short-ranged attractive colloids: A numerical study

, 2003
We study the aging dynamics in a model for dense simple liquids, in which particles interact through a hard-core repulsion complemented by a short-ranged attractive potential, of the kind found in colloidal suspensions.
Buldyrev, S., Foffi, G., Sciortino, F., Tartaglia, P., Zaccarelli, E.   +4 more
core   +1 more source

Effects of testosterone and vitamin D on fall risk in pre-frail hypogonadal men: a factorial design RCT

The Journal of Nutrition, Health and Aging
Objective: To test whether transdermal testosterone at a dose of 75 mg per day and/or monthly 24’000 IU Vitamin D reduces the fall risk in pre-frail hypogonadal men aged 65 and older.
Heike A. Bischoff-Ferrari, Melanie Kistler-Fischbacher, Stephanie Gaengler, Thomas Münzer, Bess Dawson-Hughes, Wei Lang, Robert Theiler, Andreas Egli, E. John Orav, Gregor Freystaetter   +9 more
doaj   +1 more source