Results 101 to 110 of about 4,011,650 (333)

Effects of testosterone and vitamin D on fall risk in pre-frail hypogonadal men: a factorial design RCT

The Journal of Nutrition, Health and Aging
Objective: To test whether transdermal testosterone at a dose of 75 mg per day and/or monthly 24’000 IU Vitamin D reduces the fall risk in pre-frail hypogonadal men aged 65 and older.
Heike A. Bischoff-Ferrari, Melanie Kistler-Fischbacher, Stephanie Gaengler, Thomas Münzer, Bess Dawson-Hughes, Wei Lang, Robert Theiler, Andreas Egli, E. John Orav, Gregor Freystaetter   +9 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Aging Effects Across the Metal-Insulator Transition in Two Dimensions

, 2007
Aging effects in the relaxations of conductivity of a two-dimensional electron system in Si have been studied as a function of carrier density. They reveal an abrupt change in the nature of the glassy phase at the metal-insulator transition (MIT): (a ...
Dragana Popović, J. Jaroszyński, J.-P. Bouchaud, L. C. E. Struik   +3 more
core   +1 more source

Red Blood Cell Oxidative Stress impairs oxygen delivery and induces Red Blood Cell Aging

Frontiers in Physiology, 2014
Red Blood Cells (RBCs) need to deform and squeeze through narrow capillaries. Thus, decreased deformability of RBCs contributes to the elimination of aged or damaged RBCs from the circulation.
Joy eMohanty, Enika eNagababu, Joseph M Rifkind   +2 more
doaj   +1 more source

Biophysical analysis of angiotensin II and amyloid‐β cross‐interaction in aggregation and membrane disruption

FEBS Letters, EarlyView.
Angiotensin II (AngII), a neuropeptide, interacts with amyloid‐β (Aβ), a key player in Alzheimer's disease. This study reveals that AngII reduces Aβ aggregation and membrane disruption in vitro. Biophysical assays and molecular modeling suggest AngII binds disordered Aβ forms, potentially modulating early amyloidogenic events and contributing to ...
Mohsen Habibnia, Eric Catalina‐Hernandez, Maialen Cabrerizo‐Idiazabal, Ramon Barnadas‐Rodríguez, Mario Lopez‐Martin, Alex Peralvarez‐Marin   +5 more
wiley   +1 more source

Aging Logarithmic Conformal Field Theory : a holographic view

, 2012
We consider logarithmic extensions of the correlation and response functions of scalar operators for the systems with aging as well as Schr\"odinger symmetry.
A Adams, A Ghezelbash, AL Barabási, Bom Soo Kim, BS Kim, BS Kim, BS Kim, CP Herzog, D Grumiller, D Grumiller, D Grumiller, D Son, D Yamada, DT Son, EA Bergshoeff, EA Bergshoeff, EA Bergshoeff, EG Gimon, F Family, H Hinrichsen, H Lü, H Lü, II Kogan, J Maldacena, Jaehoon Jeong, JI Jottar, JL Barbon, K Balasubramanian, K Skenderis, KA Takeuchi, KA Takeuchi, M Alishahiha, M Alishahiha, M Alishahiha, M Ammon, M Flohr, M Henkel, M Henkel, M Henkel, M Henkel, M Henkel, M Henneaux, M Kardar, M Porrati, MR Gaberdiel, N Johansson, O Aharony, S Deser, S Hyun, S Hyun, S-J Hyun, Seungjoon Hyun, SF Edwards, WD Goldberger, Y Nakayama, YS Myung   +55 more
core   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

Chimeric antigen receptors discriminate between tau and distinct amyloid-beta species

Journal of Translational Medicine
Background The lack of a definitive cure for Alzheimer's disease (AD) is fueling the search for innovative therapeutic strategies. Having revolutionized cancer immunotherapy, immune cell engineering with chimeric antigen receptors (CAR) is being explored
Cynthia J. Siebrand, Nicholas J. Bergo, Suckwon Lee, Julie K. Andersen, Chaska C. Walton   +4 more
doaj   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Physiology and pathology of calcium signaling in the brain

Frontiers in Pharmacology, 2012
Calcium (Ca2+) plays fundamental and diversified roles in neuronal plasticity. As second messenger of many signaling pathways, Ca2+ as been shown to regulate neuronal gene expression, energy production, membrane excitability, synaptogenesis, synaptic ...
Elisa Mitikp Kawamoto, Carmen eVivar, Simonetta eCamandola   +2 more
doaj   +1 more source