Results 81 to 90 of about 2,842,411 (305)

Induction of fibroblast senescence generates a non-fibrogenic myofibroblast phenotype that differentially impacts on cancer prognosis [PDF]

, 2016
Cancer-associated fibroblasts (CAF) remain a poorly characterized, heterogeneous cell population. Here we characterized two previously described tumor-promoting CAF sub-types, smooth muscle actin (SMA)-positive myofibroblasts and senescent fibroblasts ...
Brennan, PA, Clarke, J, Eliceiri, KW, Ford, K, Frampton, S, Garcia, E, Gil, J, Hanley, CJ, Herranz, N, Kabir, TD, King, EV, Lambert, DW, Lim, KP, Mellone, M, Mellows, T, Moutasim, KA, Ottensmeier, CH, Prime, SS, Thirdborough, S, Thomas, GJ, Tod, J, Underwood, TJ, Venei, V, Venturi, G, Vijayanand, P, Woelk, C, Woo, J   +26 more
core   +3 more sources

Germline TP53 Mutations Causing Diamond–Blackfan Anemia: A French Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Diamond–Blackfan anemia is a rare congenital erythroblastopenia typically caused by mutations in ribosomal protein genes. Recently, gain‐of‐function mutations in TP53 have been identified as a novel cause of Diamond–Blackfan anemia. We report two French patients who both harbored a heterozygous TP53 deletion (NM_000546.5: c.1077delA; p ...
Rafael Moisan, Lydie Da Costa, Ludivine David Nguyen, Heloise Chosseler, Audrey Riquet, Benedicte Bruno, Melissa Barbati   +6 more
wiley   +1 more source

Interplay between shear loading and structural aging in a physical gel

, 2009
We show that the aging of the mechanical relaxation of a gelatin gel exhibits the same scaling phenomenology as polymer and colloidal glasses. Besides, gelatin is known to exhibit logarithmic structural aging (stiffening). We find that stress accelerates
C. Caroli, L. C. E. Struik, O. Ronsin, S. Kutter, T. Baumberger, V. Normand   +5 more
core   +1 more source

This Is Not a Myeloproliferative Neoplasm…

Pediatric Blood &Cancer, EarlyView.
Stephanie Juané Kennedy
wiley   +1 more source

The Complexity of Standing Postural Sway Associates with Future Falls in Community-Dwelling Older Adults: The MOBILIZE Boston Study

Scientific Reports, 2017
Standing postural control is complex, meaning that it is dependent upon numerous inputs interacting across multiple temporal-spatial scales. Diminished physiologic complexity of postural sway has been linked to reduced ability to adapt to stressors.
Junhong Zhou, Daniel Habtemariam, Ikechukwu Iloputaife, Lewis A. Lipsitz, Brad Manor   +4 more
doaj   +1 more source

RNA Synthesis in the Tracheal Epithelial Cells of Aging Mice as Revealed by Electron Microscopic Radioautography [PDF]

, 2011
For the purpose of studying the aging changes of macromolecular synthesis in the tracheal epithelial cells of experimental animals, we studied 10 groups of aging mice during development and aging from fetal day 19 to postnatal month 24.
Tetsuji Nagata , Int J Cur Sci Res
core  

‘They Need to Hear You Say It’: Healthcare Professionals’ Perspectives on Barriers and Enablers to End‐of‐Life Discussions With Adolescents and Young Adults With Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT End‐of‐life conversations with adolescents and young adults (AYAs) with cancer rarely occur without the guidance of healthcare professionals. As a part of the ‘Difficult Discussions’ study, focused on palliative care and advance care planning discussions with AYAs with cancer, we investigated the factors that healthcare professionals identify ...
Justine Lee, Holly Evans, Claire E. Wakefield, Antoinette Anazodo, Richard J. Cohn, Brittany C. McGill, Elizabeth A. Lobb, Lori Wiener, Madeleine L. Juhrmann, Ursula M. Sansom‐Daly   +9 more
wiley   +1 more source

Handelin alleviates cachexia‐ and aging‐induced skeletal muscle atrophy by improving protein homeostasis and inhibiting inflammation

Journal of Cachexia, Sarcopenia and Muscle
Background Handelin is a bioactive compound from Chrysanthemum indicum L. that improves motor function and muscle integrity during aging in Caenorhabditis elegans.
Hui‐Jie Zhang, Ben‐Hui Wang, Xiang Wang, Chun‐Ping Huang, Si‐Man Xu, Jia‐Li Wang, Tian‐E Huang, Wan‐Li Xiao, Xiao‐Li Tian, Xin‐Qiang Lan, Qi‐Quan Wang, Yang Xiang   +11 more
doaj   +1 more source

Has Anyone Ever Died of Old Age? [PDF]

, 2003
The omission of aging as a legal cause of death and the largely unrecognized contribution the aging process plays in mortality is ...
Harry R. Moody, Loeonard Hayflick
core  

Hypothesis: is yeast a clock model to study the onset of humans aging phenotypes? [PDF]

, 2012
In this paper we report the growth and aging of yeast colonies derived from single cells isolated by micromanipulation and seeded one by one on separated plates to avoid growth interference by surrounding colonies.
Falcone, Claudio, Mangiapelo, Eleonora, Mazzoni, Cristina, Palermo, Vanessa   +3 more
core   +3 more sources