Results 121 to 130 of about 12,311,713 (381)

Measuring biological aging in humans: A quest

open access: yesAging Cell, 2019
The global population of individuals over the age of 65 is growing at an unprecedented rate and is expected to reach 1.6 billion by 2050. Most older individuals are affected by multiple chronic diseases, leading to complex drug treatments and increased ...
L. Ferrucci   +8 more
semanticscholar   +1 more source

Physiology and pathology of calcium signaling in the brain

open access: yesFrontiers in Pharmacology, 2012
Calcium (Ca2+) plays fundamental and diversified roles in neuronal plasticity. As second messenger of many signaling pathways, Ca2+ as been shown to regulate neuronal gene expression, energy production, membrane excitability, synaptogenesis, synaptic ...
Elisa Mitikp Kawamoto   +2 more
doaj   +1 more source

Aging Well: Informing Seniors About Local Resources Throughout The Aging Process [PDF]

open access: yes, 2017
A large portion of the Franklin County population is elderly and above the age of 60. They have many unique socioeconomic barriers to healthcare that add to the difficulty of maintaining independence in the community.
Paladugu, Sravana
core   +1 more source

Chronological aging leads to apoptosis in yeast [PDF]

open access: bronze, 2004
Eva Herker   +9 more
openalex   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

open access: yesFEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi   +5 more
wiley   +1 more source

Immunosenescence and Inflamm-Aging As Two Sides of the Same Coin: Friends or Foes?

open access: yesFrontiers in Immunology, 2018
The immune system is the most important protective physiological system of the organism. It has many connections with other systems and is, in fact, often considered as part of the larger neuro–endocrine–immune axis.
T. Fulop   +7 more
semanticscholar   +1 more source

Frailty assessment in geriatric trauma patients: comparing the predictive value of the full and a condensed version of the Fried frailty phenotype

open access: yesBMC Geriatrics
Background Frailty is associated with multiple negative outcomes in geriatric trauma patients. Simultaneously, frailty assessment including physical measurements for weakness (grip strength) and slowness (gait speed) poses challenges in this vulnerable ...
Joninah Braunschweig   +5 more
doaj   +1 more source

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

open access: yesFEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino   +7 more
wiley   +1 more source

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