Results 131 to 140 of about 12,311,713 (381)

Accumulation of Deficits as a Proxy Measure of Aging

TheScientificWorldJournal, 2001
This paper develops a method for appraising health status in elderly people. A frailty index was defined as the proportion of accumulated deficits (symptoms, signs, functional impairments, and laboratory abnormalities).
A. Mitnitski, Alexander J. Mogilner, K. Rockwood   +2 more
semanticscholar   +1 more source

Circuit training intervention for cognitive function, gut microbiota, and aging control: study protocol for a longitudinal, open-label randomized controlled trial

Trials
Background Long-term exercise is increasingly considered an effective strategy to counteract cognitive decline associated with aging. Previous studies have indicated that circuit training exercises integrating aerobic and resistance modalities positively
Keishi Soga, Michio Takahashi, Akari Uno, Takamitsu Sinada, Kentaro Oba, Keisei Kawashima, Yasuko Tatewaki, Taizen Nakase, Yasuyuki Taki   +8 more
doaj   +1 more source

Thermal treatment and mechanical properties of aluminum-2021 [PDF]

, 1970
Mechanical properties, after thermal treatments, are summarized for sheet and plate of copper-rich, high-strength, heat-treatable aluminum-2021. The alloy is quench sensitive, quench rate and variations in aging affect corrosion behavior.
Brennecke, M. W.
core   +1 more source

Aging and Holography

, 2010
Aging phenomena are examples of `non-equilibrium criticality' and can be exemplified by systems with Galilean and scaling symmetries but no time translation invariance. We realize aging holographically using a deformation of a non-relativistic version of
A Adams, A Karch, A Picone, A Volovich, AA Belavin, AJ Bray, C Duval, C Duval, C Duval, CA Fuertes, CP Herzog, CR Nappi, D Bak, D Minic, Djordje Minic, DT Son, J Maldacena, Juan I. Jottar, K Balasubramanian, K Skenderis, K Skenderis, Leopoldo A. Pando Zayas, M Henkel, M Henkel, M Henkel, M Henkel, M Henkel, M Rangamani, O Aharony, O Aharony, O DeWolfe, RG Leigh, RG Leigh, Robert G. Leigh, S Schäfer-Nameki, Y Nakayama   +35 more
core   +1 more source

Prediction of pre‐eclampsia by uterine artery Doppler imaging: relationship to gestational age at delivery and small‐for‐gestational age [PDF]

, 2008
C. K. H. Yu, O. Khouri, Nneka C. Onwudiwe, Yorgos Spiliopoulos, K. H. Nicolaides   +4 more
openalex   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

Quantitative mapping of proteasome interactomes and substrates using ProteasomeID

eLife
Proteasomes are essential molecular machines responsible for the degradation of proteins in eukaryotic cells. Altered proteasome activity has been linked to neurodegeneration, auto-immune disorders and cancer.
Aleksandar Bartolome, Julia C Heiby, Domenico Di Fraia, Ivonne Heinze, Hannah Knaudt, Ellen Spaeth, Omid Omrani, Alberto Minetti, Maleen Hofmann, Joanna M Kirkpatrick, Therese Dau, Alessandro Ori   +11 more
doaj   +1 more source

Has Anyone Ever Died of Old Age? [PDF]

, 2003
The omission of aging as a legal cause of death and the largely unrecognized contribution the aging process plays in mortality is ...
Harry R. Moody, Loeonard Hayflick
core  

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source