Results 211 to 220 of about 12,311,713 (381)
Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert +16 morewiley +1 more sourcePredictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman +17 morewiley +1 more sourcePrevalence of sarcopenia under different diagnostic criteria and the changes in muscle mass, muscle strength, and physical function with age in Chinese old adults
, 2022 Mengyu Cao, Junsong Lian, Xisheng Lin, Jinwei Liu, Chao Chen, Shuaixuan Xu, Shuang Ma, Fang Wang, Nihui Zhang, Xiaolei Qi, Xu Guogang, Nan Peng +11 moreopenalex +1 more sourceFeasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance
Molecular Oncology, EarlyView.Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis +11 morewiley +1 more sourcePGE2‐EP3 signaling exacerbates hippocampus‐dependent cognitive impairment after laparotomy by reducing expression levels of hippocampal synaptic plasticity‐related proteins in aged mice [PDF]
, 2018 Jing‐Yu Xiao, Bingrui Xiong, Wen Zhang, Wenchang Zhou, Hui Yang, Feng Gao, Hong‐Bing Xiang, Anne Manyande, Xuebi Tian, Yuke Tian +9 moreopenalex +1 more sourceNew insights into molecular changes in skeletal muscle aging and disease: Differential alternative splicing and senescence
, 2021 Elizaveta M. Solovyeva, Chikwendu Ibebunjo, Stephan Utzinger, John K. Eash, Andrew Dunbar, Ulrike Naumann, Yunyu Zhang, Fabrizio C. Serluca, Sabrina Demirci, Berndt Oberhauser, Frederique Black, Martin Rausch, Sebastian Hoersch, Angelika Meyer +13 moreopenalex +1 more sourceAggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera +11 morewiley +1 more sourceUsing an age-dependent D-dimer cut-off value increases the number of older patients in whom deep vein thrombosis can be safely excluded
, 2012 Renée A. Douma, Minkang Tan, Roger E. G. Schutgens, Shannon M. Bates, Arnaud Perrier, Cristina Legnani, Douwe H. Biesma, Jeffrey S. Ginsberg, H Bounameaux, Gualtiero Palareti, Marc Carrier, Gerben C. Mol, Grégoire Le Gal, Pieter W. Kamphuisen, Marc Righini +14 moreopenalex +2 more sources
