Results 71 to 80 of about 4,011,650 (333)

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Addiction to RUNX in lymphoma [PDF]

, 2016
No abstract ...
Borland, Gillian, Kilbey, Anna, Neil, James C.   +2 more
core   +1 more source

The multidrug and toxin extrusion (MATE) transporter DTX51 antagonizes non‐cell‐autonomous HLS1–AMP1 signaling in a region‐specific manner

FEBS Letters, EarlyView.
The Arabidopsis mutants hls1 hlh1 and amp1 lamp1 exhibit pleiotropic developmental phenotypes. Although the functions of the causative genes remain unclear, they act in the same genetic pathway and are thought to generate non‐cell‐autonomous signals.
Takashi Nobusawa, Makoto Kusaba
wiley   +1 more source

Thermally Activated Magnetization and Resistance Decay during Near Ambient Temperature Aging of Co Nanoflakes in a Confining Semi-metallic Environment

, 2011
We report the observation of magnetic and resistive aging in a self assembled nanoparticle system produced in a multilayer Co/Sb sandwich. The aging decays are characterized by an initial slow decay followed by a more rapid decay in both the ...
Aaron Barnes, Benjamin Grove, Christopher Heidt, Gregory. G. Kenning, Henkel Malte, James Martin, Michael Madden, Morrish A. H., Neel L., Struik L. C. E., Weast Robert C.   +10 more
core   +1 more source

How financial incentives induce disability insurance recipients to return to work [PDF]

, 2014
Using a local randomized experiment that arises from a sharp discontinuity in Disability Insurance (DI) policy in Norway, we provide transparent and credible identification of how financial incentives induce DI recipients to return to work.
Kostøl, AR, Mogstad, M
core   +1 more source

A human neuron Alzheimer’s disease model reveals barriers to senolytic translatability

Alzheimer’s Research & Therapy
Therapeutic successes in mouse models of Alzheimer’s disease (AD) largely fail to translate into clinical trials, with experimental drugs rarely validated in human models before being administered to humans.
Chaska C. Walton, Ellen Wang, Suckwon Lee, Cynthia J. Siebrand, Nicholas J. Bergo, Zachary Mayeri, Julie K. Andersen   +6 more
doaj   +1 more source

Core belief disruption amid the COVID-19 pandemic in Japanese adults

Humanities & Social Sciences Communications, 2021
Due to the rapid spread of the novel coronavirus disease (COVID-19) worldwide, most people have been forced to alter their lifestyles. This situation may affect the mental health of individuals through the disruption of core beliefs about humans, the ...
Izumi Matsudaira, Yuji Takano, Ryo Yamaguchi, Yasuyuki Taki   +3 more
doaj   +1 more source

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

FEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile, Daniela Ratto, Giorgia Rastelli, Ottavia Eleonora Ferraro, Caterina Temporini, Sunil Kumar, Simona Boncompagni, Paola Rossi, Monica Canepari   +8 more
wiley   +1 more source

The nicotinamide hypothesis revisited—plant defense signaling integrating PARP, nicotinamide, nicotinic acid, epigenetics, and glutathione

FEBS Letters, EarlyView.
Nicotinamide (NIC) and nicotinic acid (NIA) are proposed as stress signaling compounds in plants. Oxidative stress may lead to single strand breaks (SSB) in DNA, which activate poly(ADP‐ribose) polymerase (PARP). NIC and NIA are then formed from NAD. NIC and NIA can promote epigenetic changes leading to the expression of defense genes specific for the ...
Torkel Berglund, Anna B. Ohlsson
wiley   +1 more source

Aging in the Relaxor Ferroelectric PMN/PT [PDF]

, 2006
The relaxor ferroelectric (PbMn$_{1/3}$Nb$_{2/3}$O$_3$)$_{1-x}$(PbTiO$_3$)$_{x}$, $x=0.1$, (PMN/PT(90/10)) is found to exhibit several regimes of complicated aging behavior. Just below the susceptibility peak there is a regime exhibiting rejuvenation but
E. V. Colla, Eugene V. Colla, G. A. Smolenskii, J. Hammann, L. E. Cross, L. E. Cross, Lambert K. Chao, M. B. Weissman, M. B. Weissman, V. A. Trepakov   +9 more
core   +1 more source