Results 81 to 90 of about 12,311,713 (381)
Rejuvenation by cell reprogramming: A new horizon in gerontology [PDF]
, 2018 The discovery of animal cloning and subsequent development of cell reprogramming technology were quantum leaps as they led to the achievement of rejuvenation by cell reprogramming and the emerging view that aging is a reversible epigenetic process. Here,
Brown, Oscar Alfredo +5 more
core +2 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Objectives To identify predictors of chronic ITP (cITP) and to develop a model based on several machine learning (ML) methods to estimate the individual risk of chronicity at the timepoint of diagnosis. Methods We analyzed a longitudinal cohort of 944 children enrolled in the Intercontinental Cooperative immune thrombocytopenia (ITP) Study ...
Severin Kasser +6 more
wiley +1 more source
Clonal hematopoiesis in human aging and disease
Science, 2019 Cryptic signs of aging in our blood Time is not a friend to our DNA. Aging is associated with an accumulation of somatic mutations in normal dividing cells, including the hematopoietic stem cells (HSCs) that give rise to all blood cells.
S. Jaiswal, B. Ebert
semanticscholar +1 more source
Core belief disruption amid the COVID-19 pandemic in Japanese adults
Humanities & Social Sciences Communications, 2021 Due to the rapid spread of the novel coronavirus disease (COVID-19) worldwide, most people have been forced to alter their lifestyles. This situation may affect the mental health of individuals through the disruption of core beliefs about humans, the ...
Izumi Matsudaira +3 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Surveillance imaging aims to detect tumour relapse before symptoms develop, but it's unclear whether earlier detection of relapse leads to better outcomes in children and young people (CYP) with medulloblastoma and ependymoma. This systematic review aims to identify relevant literature to determine the efficacy of surveillance magnetic ...
Lucy Shepherd +3 more
wiley +1 more source
Molecular Mechanisms of Dermal Aging and Antiaging Approaches
International Journal of Molecular Sciences, 2019 The dermis is primarily composed of the extracellular matrix (ECM) and fibroblasts. During the aging process, the dermis undergoes significant changes.
J. Shin +6 more
semanticscholar +1 more source
Aging as dynamics in configuration space
, 1999 The relaxation dynamics of many disordered systems, such as structural glasses, proteins, granular materials or spin glasses, is not completely frozen even at very low temperatures. This residual motion leads to a change of the properties of the material,
Kob, Walter +2 more
core +2 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Introduction Neuroblastoma (NB) with central nervous system (CNS) metastases is rare at diagnosis, but occurs more often during relapse/progression. Patients with CNS metastases face a dismal prognosis, with no standardized curative treatment available.
Vicente Santa‐Maria Lopez +13 more
wiley +1 more source
Hallmarks of aging: An expanding universe
Cell, 2022 C. López-Otín +4 more
semanticscholar +1 more source
Normal aging induces A1-like astrocyte reactivity
Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance In aging, the brain becomes vulnerable to injury and cognitive function declines, but the mechanisms responsible are unknown. Astrocytes, the most abundant class of glial cells, are vital for the proper function of the central nervous system,
L. Clarke +5 more
semanticscholar +1 more source