Results 81 to 90 of about 2,198,545 (274)
npj Regenerative MedicineSkeletal muscle function crucially depends on innervation while repair of skeletal muscle relies on resident muscle stem cells (MuSCs). However, it is poorly understood how innervation affects MuSC properties and thereby regeneration of skeletal muscle ...
Henriette Henze +6 more
doaj +1 more source
The Neuromuscular Junction (NMJ): aging at the crossroad between nerves and muscle
Frontiers in Aging Neuroscience, 2014 Aging is associated with a progressive loss of muscle mass and strength and a decline in neurophysiological functions. Age-related neuromuscular junction (NMJ) plays a key role in musculoskeletal impairment that occurs with aging.
Marta eGonzalez-Freire +6 more
doaj +1 more source
General functions for human survival and mortality [PDF]
arXiv, 2004 General functions for human survival and mortality may support a possibility of general mechanisms in human ageing. We discovered that the survival and mortality curves could be described very simply and accurately by the Weibull survival function with age-dependent shape parameter.
arxiv
Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer
Molecular Oncology, EarlyView.mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia +17 more
wiley +1 more source
Age determinations of the open star clusters King 14 and NGC 146 [PDF]
Comptes rendus de l'Academie bulgare des Sciences 2005, 58, 12,
1363, 2008 We based on 2MASS J and Ks photometry for the open star clusters King 14 and NGC 146, and using color magnitude diagrams with isochrones fit we have found an age of log(age) = 7.8 (63 $\pm$8 Myr) for King 14 and log(age) = 7.5 (32 $\pm$8 Myr) for NGC 146. Our age determination is bigger than given in Lynga [5] (log(age) = 7.2 for King 14 and log(age) =
arxiv
Molecular Oncology, EarlyView.Prostate cancer is a leading malignancy with significant clinical heterogeneity in men. An 11‐gene signature derived from dysregulated epithelial cell markers effectively predicted biochemical recurrence‐free survival in patients who underwent radical surgery or radiotherapy.
Zhuofan Mou, Lorna W. Harries
wiley +1 more source
Chimeric antigen receptors discriminate between tau and distinct amyloid-beta species
Journal of Translational MedicineBackground The lack of a definitive cure for Alzheimer's disease (AD) is fueling the search for innovative therapeutic strategies. Having revolutionized cancer immunotherapy, immune cell engineering with chimeric antigen receptors (CAR) is being explored
Cynthia J. Siebrand +4 more
doaj +1 more source
On Relative Ageing of Coherent Systems with Dependent Identically Distributed Components [PDF]
arXiv, 2019 Relative ageing describes how a system ages with respect to another one. The ageing faster orders are the ones which compare the relative ageings of two systems. Here, we study ageing faster orders in the hazard and the reversed hazard rates. We provide some sufficient conditions for proving that one coherent system dominates another system with ...
arxiv
Molecular Oncology, EarlyView.MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin +14 more
wiley +1 more source