Results 121 to 130 of about 12,999,964 (309)

Department of Aging, BELTSS seek hearing examiners

, 2012
Jan. 12, 2012-; " ... A blog-like publication that connects interest Ohioans to news and information about issues affecting older Ohioans and the people who care for and serve them."; Not published Feb.-Nov. 2013.; Issue for Jan.

core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Differences in self-rated health among older adults according to socioeconomic circumstances: the Bambuí Health and Aging Study

Cadernos de Saúde Pública
Self-rated health is influenced by socioeconomic circumstances, but related differences in its structure have received little attention. The objective of this study was to examine whether self-rated health structure differs according to socioeconomic ...
Maria Fernanda Lima-Costa, Josélia Oliveira Araújo Firmo, Elizabeth Uchôa   +2 more
doaj  

Interpretable machine learning for high-dimensional trajectories of aging health. [PDF]

PLoS Comput Biol, 2022
Farrell S, Mitnitski A, Rockwood K, Rutenberg AD.   +3 more
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Preditores cardiovasculares da mortalidade em idosos longevos

Cadernos de Saúde Pública
O objetivo deste trabalho é investigar a associação entre fatores de risco e morbidade cardiovascular com mortalidade em idosos longevos. Noventa e um por cento da população com idade ³ 80 anos (n = 193) de Veranópolis, Rio Grande do Sul, no ano de 1996,
Luiz Pedro Marafon, Ivana Beatrice Manica da Cruz, Carla Helena Augustin Schwanke, Emílio Hideyuki Moriguchi   +3 more
doaj  

Nicotinamide mononucleotide (NMN) as an anti-aging health product - Promises and safety concerns. [PDF]

J Adv Res, 2022
Nadeeshani H, Li J, Ying T, Zhang B, Lu J.   +4 more
europepmc   +1 more source

Aging in place begins in the bathroom

, 2012
Jan. 12, 2012-; "... A blog-like publication that connects interest Ohioans to news and information about issues affecting older Ohioans and the people who care for and serve them."; Not published Feb.-Nov. 2013.; Issue for Jan.

core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Perfil do idoso em área metropolitana na região sudeste do Brasil: resultados de inquérito domiciliar

Revista de Saúde Pública
Trata-se de estudo multicêntrico visando levantar as necessidades de saúde da população de idosos residentes em zona urbana, conduzido em 6 países na América Latina e coordenado pela Organização Panamericana da Saúde. No Brasil, 1.602 idosos (60 anos e +)
Luiz Roberto Ramos, Tereza Etsuko da C. Rosa, Zélia M. Oliveira, Maria Célia G. Medina, Francisco R. G. Santos   +4 more
doaj