Results 241 to 250 of about 12,999,964 (309)

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

Exploring the Mediating Roles of Aging Perceptions and Physical Activity on Healthy Aging Perspectives Among Older Adults With Chronic Diseases in Taiwan and China: A Cross-Sectional Study. [PDF]

Geriatr Gerontol Int
Wang YR, Lin FM, Ye L, Yu L, Kang J, Biddle M, Chen CM.   +6 more
europepmc   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

Unequal Embodiment: Racial and Ethnic Heterogeneity in the Predictors and Age-Related Health Outcomes Associated with Accelerated Biological Aging. [PDF]

J Gerontol A Biol Sci Med Sci
Villalba Madrid M, Ríos Casas F, Farina MP.   +2 more
europepmc   +1 more source

Corrigendum to "Effects of a Multidomain Intervention on Physical Performance and Sarcopenia in Long-Term Care Facility Residents: the I-COUNT Pilot Randomized Controlled Trial" [J Nutr Health Aging, 30 (2026) 100943]. [PDF]

J Nutr Health Aging
Ceolin C, Pasolini G, Papa MV, Scotti G, Bobbo A, Macchia E, Ghidini A, Romeo Z, Sergi G, De Rui M, Gentile S, Maggi S, Morandi A, Noale M, ICOUNT study group.   +14 more
europepmc   +1 more source

Mapping the impact of intrinsic capacity on healthcare use. [PDF]

J Nutr Health Aging
Chen IT, Lu WH, Hsiao FY, Chen LK.
europepmc   +1 more source