Results 111 to 120 of about 6,020,277 (309)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

[Coalition for Aging LGBT General Preparation Resources]

Coalition for Aging LGBT General Preparation Resources document from the Coalition for Aging LGBT Records (The Dallas Way)
Coalition for Aging LGBT
core  

Aging with developmental disabilities

, 2012
Jan. 12, 2012-; "... A blog-like publication that connects interest Ohioans to news and information about issues affecting older Ohioans and the people who care for and serve them."; Not published Feb.-Nov. 2013.; Issue for Jan.
Ohio Department of Devvelopmental Disabilities
core  

The long-term changing patterns of suicide mortality in China from 1987 to 2020: continuing urban-rural disparity

BMC Public Health
Background Over the past three decades, China has experienced significant changes in urban-rural, gender, and age-specific suicide mortality patterns. This study aimed to investigate the long-term trends in suicide mortality in China from 1987 to 2020 ...
Yu Wu, Binbin Su, Panliang Zhong, Yiran Wang, Yueqin Huang, Xiaoying Zheng   +5 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Multi-dimensional sleep health and dementia risk: a prospective study in the UK Biobank

BMC Medicine
Background The intricate interplay of various sleep characteristics may influence dementia risk through different pathogenic pathways. However, few studies have examined multi-dimensional sleep health in relation to dementia risk or explored potential ...
Tianyi Huang, May A. Beydoun, Sina Kianersi, Susan Redline, Lenore J. Launer   +4 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Be the voice. Take action. Tigether

, 2012
Jan. 12, 2012-; "... A blog-like publication that connects interest Ohioans to news and information about issues affecting older Ohioans and the people who care for and serve them."; Not published Feb.-Nov. 2013.; Issue for Jan.
Western Reserve Area Agency on Aging, Perkins, Fatima   +1 more
core  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

ezBIDS: Guided standardization of neuroimaging data interoperable with major data archives and platforms

Scientific Data
Data standardization promotes a common framework through which researchers can utilize others’ data and is one of the leading methods neuroimaging researchers use to share and replicate findings.
Daniel Levitas, Soichi Hayashi, Sophia Vinci-Booher, Anibal Heinsfeld, Dheeraj Bhatia, Nicholas Lee, Anthony Galassi, Guiomar Niso, Franco Pestilli   +8 more
doaj   +1 more source