Results 181 to 190 of about 290,636 (313)
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Aged cells in human skeletal muscle after resistance exercise
, 2018 [[abstract]]It remains unclear how exercise, as an entropic event, brings benefit against human aging. Here we examined longitudinal changes of p16Ink4a+ senescent cells in skeletal muscle of young men (aged 22.5±1.7 y) before and after resistance ...
Yang, Chi;Yang, Chi;Jiao, Ying;Jiao, Ying;Wei, Bing;Wei, Bing;Yang, Zeyi;Yang, Zeyi;Wu, Jin-Fu;Wu, Jin-Fu;Jense, Jorgen;Jensen, Jorgen;Je, Wei-Horng;Jean, Wei-Horng;黃志揚;Huang, Chih-Yang;郭家驊;Kuo, Chia-Hua;*
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Rheological Behavior and Aging Resistance of SBS/Lignin Composite Modified Asphalt. [PDF]
Polymers (Basel)Wu W, Li L, Huang M, Liang J, Li Z.
europepmc +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi +2 more
wiley +1 more source
Effect and Mechanism of Red Mud on the Aging Resistance of Asphalt. [PDF]
Materials (Basel)Wu J +5 more
europepmc +1 more source
Investigating the pavement performance and aging resistance of modified bio-asphalt with nano-particles. [PDF]
PLoS One, 2020 Ren J, Zang G, Wang S, Shi J, Wang Y.
europepmc +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background SOX1 antibody‐positive paraneoplastic neurological syndromes (PNS) exhibit significant population‐specific clinical heterogeneity. While Western cohorts predominantly manifest Lambert‐Eaton myasthenic syndrome (65%–80%), comprehensive clinical characterization and treatment response data in Asian populations remain critically ...
Jin‐Long Ye +11 more
wiley +1 more source
Impact of Waste-HydroChar on the Rheological Behavior, Physical Properties, and Aging Resistance of Bitumen. [PDF]
Materials (Basel)Dintcheva NT +6 more
europepmc +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To delineate specific in vivo white matter pathology in neuronal intranuclear inclusion disease (NIID) using diffusion spectrum imaging (DSI) and define its clinical relevance. Methods DSI was performed on 42 NIID patients and 38 matched controls.
Kaiyan Jiang +10 more
wiley +1 more source