Results 51 to 60 of about 1,437,301 (294)

Studies on the β → α Phase Transition Kinetics of Ti–3.5Al–5Mo–4V Alloy under Isothermal Conditions by X-ray Diffraction

open access: yesMetals, 2020
The β → α phase transition kinetics of the Ti−3.5Al−5Mo−4V alloy with two different grain sizes was investigated at the isothermal temperature of 500 °C. A method to estimate the function of the precipitate fraction
Panpan Ge   +3 more
doaj   +1 more source

CARTILAGE AGEING AND TREATMENT POSSIBILITIES

open access: yesWiadomości Lekarskie, 2019
Osteoarthritis is the disease connected with aging which is characterised by progressive degeneration of all elements building the joint but also influencing the muscles constituting motor unit with the affected joint. The effective and unified therapy has not been yet introduced despite the broad multi-site studies concentrating on metabolic pathways ...
openaire   +2 more sources

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Influence of Single- and Double-Aging Treatments on the Mechanical and Corrosion Resistance of Alloy 625

open access: yesMetals
Nickel–chromium–molybdenum Alloy 625 exhibits an excellent combination of mechanical properties and corrosion resistance. However, the high-temperature plastic deformation process and the heat treatment represent critical aspects for the loss in ...
Barbara Rivolta   +2 more
doaj   +1 more source

Failure Analysis of a Chromium Plating Layer on a Piston Rod Surface and the Study of Ni-Based Composite Coating with Nb Addition by Laser Cladding

open access: yesMetals, 2022
The failure of a chromium plating layer on the surface of a piston rod was analyzed, and an Ni-based alloy mixed with a niobium (Nb) composite coating was investigated by means of stereomicroscopy, metallographic microscopy, scanning electron microscopy (
Jiangang Wang   +7 more
doaj   +1 more source

Long-term lithium treatment in bipolar disorder. effects on glomerular filtration rate and other metabolic parameters [PDF]

open access: yes, 2017
.BACKGROUND: Concerns about potential adverse effects of long-term exposure to lithium as a mood-stabilizing treatment notably include altered renal function.
Abramowicz, Maria   +26 more
core   +3 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

The Effect of Aging on Precipitates, Mechanical and Magnetic Properties of Fe-21Cr-15Ni-6Mn-Nb Low Magnetic Stainless Steel

open access: yesMetals, 2021
The effect of aging on the precipitates, mechanical and magnetic properties of Fe-21Cr-15Ni-6Mn-Nb low magnetic stainless steel were investigated. The steel was aged at 550–750 °C for 2 h after solution heat treatment at 1100 °C for 1 h. During the aging
Changsheng Li   +4 more
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

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