Results 71 to 80 of about 1,437,301 (294)

Age-related macular degeneration: current treatments

Clinical Ophthalmology, 2009
Although important progress has been made in understanding age-related macular degeneration (AMD), management of the disease continues to be a challenge. AMD research has led to a widening of available treatment options and improved prognostic perspectives.
Hubschman, Jean Pierre, Reddy, Shantan, Schwartz, Steven D   +2 more
openaire   +6 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

T2D-LVDD: neural network-based predictive models for left ventricular diastolic dysfunction in type 2 diabetes

Diabetology & Metabolic Syndrome
Cardiovascular disease complications are the leading cause of morbidity and mortality in patients with Type 2 diabetes (T2DM). Left ventricular diastolic dysfunction (LVDD) is one of the earliest myocardial characteristics of diabetic cardiac dysfunction.
Yu Rong, Wei Liu, Ke Li, Jian Guo, Xue-Ping Li   +4 more
doaj   +1 more source

Age-related changes of apoptotic cell death in human lymphocytes [PDF]

, 2006
Apoptosis seems to be involved in immunosenescence associated with aging. Moreover, in lymphocytes (PBL) of patients with Alzheimer's disease, an increased susceptibility to the apoptotic pathway has been described possibly due to impaired protection of ...
Eckert, Anne, Leutner, Silke, Müller, Walter E., Schindowski, Katharina   +3 more
core  

Pharmacological And Genetic Reversal Of Age-Dependent Cognitive Deficits Attributable To Decreased Presenilin Function [PDF]

, 2010
Alzheimer\u27s disease (AD) is the leading cause of cognitive loss and neurodegeneration in the developed world. Although its genetic and environmental causes are not generally known, familial forms of the disease (FAD) are attributable to mutations in a
Bell, A. J., Chiorean, S., Choi, C. H., Choi, R. J., Ferreiro, D., Ferrick, N. J., Fortini, M. E., Hinchey, P., Jongens, T. A., Koenigsberg, E., Kollaros, M., Liebelt, D. A., McBride, S. M.J., McDonald, T. V., Nguyen, H. T., Rudominer, R. L., Schoenfeld, B. P., Siwicki, Kathleen King, Sumida, A., Terlizzi, A. M.   +19 more
core   +2 more sources

Inhibition of USP7 activity selectively eliminates senescent cells in part via restoration of p53 activity. [PDF]

, 2020
The accumulation of senescent cells (SnCs) is a causal factor of various age-related diseases as well as some of the side effects of chemotherapy. Pharmacological elimination of SnCs (senolysis) has the potential to be developed into novel therapeutic ...
Budamagunta, Vivekananda, Campisi, Judith, He, Yonghan, Li, Wen, Lv, Dongwen, Ortiz, Yuma T, Zhang, Xin, Zhang, Xuan, Zheng, Guangrong, Zhou, Daohong   +9 more
core   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Nonlinear ultrasonic characterization of γ΄ phase evolution in DZ411 alloy after long-term aging

Cailiao gongcheng
To explore the feasibility of the nonlinear ultrasonic method in the aging microstructure evolution application of directionally solidified nickel-based superalloy， DZ411 directionally solidified nickel-based superalloy is studied.The microstructure ...
YANG Gangzhengliang, LI Ping, CAO Tieshan, ZHAO Jie   +3 more
doaj   +1 more source

Influence of severe plastic deformation on the precipitation hardening of a FeSiTi steel [PDF]

, 2012
The combined strengthening effects of grain refinement and high precipitated volume fraction (~6at.%) on the mechanical properties of FeSiTi alloy subjected to SPD processing prior to aging treatment were investigated by atom probe tomography and ...
A Cerri, A. Fillon, A. Pougis, BB Straumal, D. Barbier, DH Jack, DH Jack, DJ Abson, E Ma, E Ma, EO Hall, G Martin, G Sha, GD Costa, H Swygenhoven Van, J Cizek, JK Kim, JP Henon, JW Cahn, K Ohashi, L. S. Toth, M Lewandowska, NJ Petch, O. Bouaziz, R Valiev, R Wasmuht, R. Arruffat, RB Nicholson, RZ Valiev, S Cheng, WJ Kim, X Sauvage, X. Sauvage, YH Zhao, YH Zhao, YT Zhu, Z Horita, Z Horita   +37 more
core   +3 more sources

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source