Results 121 to 130 of about 1,230,789 (298)
An evaluation of deep learning achieved by students studying environmental science modules using the Wolverhampton Online Learning Framework (WOLF) [PDF]
, 2003 Report of a CELT project on supporting students through innovation and researchThe Division of Environmental and Analytical Sciences uses the Wolverhampton Online Learning Framework (WOLF) for part of its module delivery programme at all 3 levels within ...
Simkins, Andrew, Roberts, Clive L.
core
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Disagreeing to Agree: Problem-Solving and Knowledge Production
Organization TheoryGabriel Abend identifies too much disagreement as an obstruction to the pursuit of knowledge. This paper introduces problem-solving sociology as a method of knowledge production that can avoid this difficulty. I outline the communal, pragmatist tenets of
Monica Prasad
doaj +1 more source
Pedigree-Based Genetic Diversity in the South African Boerboel Dog Breed
AnimalsThe Boerboel dog breed (BBD) is indigenous to South Africa (SA) and plays an important role in safeguarding homes and farms. The Department of Agriculture, Land Reform, and Rural Development (DALRRD) classifies the BBD as a protected species, and it is ...
Ripfumelo Success Mabunda +3 more
doaj +1 more source
, 1999 In Chomsky (1998), Move is defined as a composite operation consisting of three components: Agree, Identify and Merge. I will argue that the definition of Move as a composite syntactic operation cannot be maintained.
Lee, Hong Bae
core
, 2019 Median agreement (1 = strongly disagree, 2 = disagree, 3 = neutral, 4 = agree, 5 = strongly agree) with each attitudinal statement, and the percentage (number) of farmers to agree or strongly agree, and disagree or strongly disagree with each statement.
Faical Akaichi (7841219) +4 more
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
, 2022 The AGREE model is an integrated framework to quantitatively analyse the impacts of changes in the economy and policy on AGriculture, Resources, Environment and Energy. While covering the four domains, the model framework is kept as simple as possible to
Henseler, Martin
core
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source