Results 131 to 140 of about 1,105,732 (303)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

On Long-Distance Agree

, 2010
The present work examines the empirical reach of the minimalist operation Agree responsible for feature-licensing. I focus on patterns of so-called long-distance agreement and show that although not all instances of long-distance agreement that have been
Boeckx, Cedric
core  

Assessing the quality and integrating the evidence and strength of recommendations in the guidelines for gastric precancerous lesions

BMC Cancer
Background Clinical practice guidelines (CPGs) are intended to offer appropriate recommendations for clinical practice based on the available evidence while acknowledging existing gaps and uncertainties.
Jia-yin Ou, Yang Liu, Lang Zhang, Tian-qi Luo, Jia-yu Li, Li-ming Lu, Lin Wang, Qiu-rong He, Xin Liu, Hua-feng Pan   +9 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Economic and environmental analysis of energy efficiency measures in agriculture. Case Studies and trade offs.

, 2012
This report is the result of the collaboration of the partners of the AGREE work-package “Economic and environmental analysis”, which is based on case study analyses of the partners in seven countries of the EU.
Jubaer, H, de Visser, C, Mikkola, H, Louro, M, Esala, J, Golaszewski, J, Daalgard, T, Balafoutis, A, Scholz, L, Panagakis, P, Meyer-Aurich, A, Brodzinski, Z, Yli-Kojola, H, van der Voort, M, Briassoulis, D, Stanghellini, C, Wemmenhove, H, Klop, A, Baptista, F, Rajaniemi, M, Silva, LL, Peça, JO, Marques, C, Mistriotis, A, Stolarski, M, Silva, JR, Ahokas, J, Murcho, D, Ziegler, T, Olba-Ziety, E, Ellen, H, Myhan, R, Jokiniemi, T   +32 more
core  

The Use of Plant Extracts to Improve Male Reproductive Performance: A Review Focusing on Mammalian Semen Quality and Preservation

Agriculture
In African countries and many developing countries, communal farmers rely on livestock such as cattle, goats, and sheep to support food security, income, and agricultural activities.
Rantloko Rolly Maapola, Khathutshelo Agree Nephawe, Masindi Lottus Mphaphathi, Jabulani Nkululeko Ngcobo   +3 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

RIGHT/AGREE 2 NCCN guidelines

, 2018
Introduction: Robust, clearly reported clinical practice guidelines (CPGs) are essential for evidence-based clinical practice. The Reporting Items for practice Guidelines in HealThcare (RIGHT) statement and Appraisal of Guidelines for Research and ...
Christian Cole Wayant
core   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source