Results 121 to 130 of about 315,422 (280)

Validation and reliability of a guideline appraisal mini-checklist for daily practice use

BMC Medical Research Methodology, 2016
Background The use of comprehensive instruments for guideline appraisal is time-consuming and requires highly qualified personnel. Since practicing physicians are generally busy, the rapid-assessment Mini-Checklist (MiChe) tool was developed to help them
Andrea Siebenhofer, Thomas Semlitsch, Thomas Herborn, Ulrich Siering, Ina Kopp, Johannes Hartig   +5 more
doaj   +1 more source

Critical assessment of geriatric oncology guidelines based on the AGREE II tool

Journal of Geriatric Oncology
The world's population is aging rapidly and older adults carry a disproportionate cancer burden. Despite this, older patients remain underrepresented in clinical research. As a result, the evidence base informing guideline development remains limited. Existing guidelines vary in methodological quality and applicability. We aimed to evaluate the quality
Gayathri, Nair, Cailyn H, Livingstone, Jonathon W, Vundum, Mathew, George   +3 more
openaire   +2 more sources

AGREE II scaled domain scores of CPGs for SSI prevention.

, 2018
AGREE II scaled domain scores of CPGs for SSI prevention.
Brigid M. Gillespie (5746136), Shelley Roberts (4239160), Claudia Bull (5746139), Wendy Chaboyer (4239157), Rachel Walker (5746142), Frances Lin (4761384)   +5 more
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Systematic Review of the Methodology Quality in Lung Cancer Screening Guidelines

Chinese Journal of Lung Cancer, 2016
Background and objective Lung cancer is the most common malignancy and screening can decrease the mortality. High quality screening guideline is necessary and important for effective work. Our study is to review and evaluate the basic characteristics and
Jiang LI, Kai SU, Fang LI, Wei TANG, Yao HUANG, Le WANG, Huiyao HUANG, Jufang SHI, Min DAI   +8 more
doaj   +1 more source

Author Correction: AGREE-S: AGREE II extension for surgical interventions: appraisal instrument

Surgical Endoscopy, 2022
Antoniou S. A., Florez I. D., Markar S., Logullo P., Lopez-Cano M., Silecchia G., Antoniou G. A., Tsokani S., Mavridis D., Brouwers M., Dayem Y. S. A., Bertolaccini L., Alonso-Coello P., Akl E., Chand M., Como J. J., de Borst G. J., Di Saverio S., Emile S., Eom B. W., Gorter R., Hanna G., Immonen K., Lai Q., Lumen N., Mathew J. L., Montendori A., Moya M., Pellino G., Sanabria A., Saratzis A., Smart N., Stefanidis D., Zaninotto G.   +33 more
openaire   +2 more sources

AGREE II domain-standardized scores for CPGs on vancomycin TDM.

, 2014
AGREE II domain-standardized scores for CPGs on vancomycin TDM.
Zhi-Kang Ye (474245), Can Li (31070), Suo-Di Zhai (408300)   +2 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Appraisal of guidelines and variations in recommendations on drug therapy for invasive aspergillosis prevention and treatment

Frontiers in Pharmacology
BackgroundIn recent years, many guidelines related to aspergillosis have been published worldwide. However, no studies have applied assessment tools to systematically evaluate the quality of these guidelines.ObjectivesThis study aimed to assess the ...
Jing Wang, Ju Sun, Da-Wei Yang, Hai-Shan Wang, Wei Meng, Hong-Yan Li   +5 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source