Results 141 to 150 of about 6,295,269 (238)

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Methodological quality of nursing guidelines in China: an AGREE II and RIGHT appraisal (2023-2024). [PDF]

BMC Nurs
Xuan M, Wang D, Fan T, Zhao W, Liang W, Liu N, Li H, Hou R, Ming X.   +8 more
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Quality of guidelines for the management and prevention of occupational risks during pregnancy: a systematic quality assessment using the Appraisal of Guidelines for Research and Evaluation (AGREE II). [PDF]

Scand J Work Environ Health
Lupia M, Solà I, Villar R, Culqui M, Díaz P, Santero M, Mirabent J, Benavides FG, Serra C.   +8 more
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Elaiussa Sebaste II- Un porto fra Oriente e Occidente

, 2003
(a cura di E.Equini Schneider)
II, EQUINI, Eugenia
core  

Clinical practice guidelines and quality standards for early intervention in psychosis: an AGREE II appraisal and systematic review of service components. [PDF]

Front Psychiatry
Scognamiglio P, Martiadis V, Diaspro G, Viacava L, Longobardi A, Rea R, Iniziato V, Saviano P, La Pia S.   +8 more
europepmc   +1 more source

A critical appraisal of urolithiasis clinical practice guidelines using the AGREE II instrument. [PDF]

Transl Androl Urol, 2023
Zou B, Zhou Y, He Z, Zhou X, Dong S, Zheng X, Xu R, Duan X, Zeng G.   +8 more
europepmc   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

A Systematic Critical Appraisal of Clinical Practice Guidelines for Non-Pharmacological ‎Conservative Management of Complex Regional Pain Syndrome (CRPS) Using the ‎AGREE-II Instrument. [PDF]

J Eval Clin Pract
Shafiee E, MacDermid J, Packham T, Grewal R, Walton D, Farzad M.   +5 more
europepmc   +1 more source