Results 111 to 120 of about 2,442,342 (290)

New Physics at Low Accelerations (MOND): an Alternative to Dark Matter

open access: yes, 2010
I describe the MOND paradigm, which posits a departure from standard physics below a certain acceleration scale. This acceleration as deduced from the dynamics in galaxies is found mysteriously to agree with the cosmic acceleration scales defined by the ...
Milgrom, Mordehai
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

A Green Workflow to Determine Flavonoids from Physalis angulata L.: Extraction Optimization by Response Surface Method and Spectrophotometric Method Validation

open access: yesSpectroscopy Journal
Wild Physalis angulata L. has promising medicinal potential due to its rich flavonoids. However, a green analytical approach for these compounds from this plant has not yet been thoroughly optimized.
Huynh Tran Mai Lan Anh   +6 more
doaj   +1 more source

Positive, negative, and bipolar questions: The effect of question polarity on ratings of text readability

open access: yesSurvey Research Methods, 2013
For decades, survey researchers have known that respondents give different answers to attitude questions worded positively (X is good. Agree-Disagree), negatively (X is bad. Agree-Disagree) or on a bipolar scale (X is bad-good). This makes survey answers
Naomi Kamoen   +3 more
doaj   +1 more source

Molecular cancer prevention: Intercepting disease

open access: yesMolecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco   +2 more
wiley   +1 more source

Actions required to implement integrated care for older people in the community using the World Health Organization's ICOPE approach: A global Delphi consensus study.

open access: yesPLoS ONE, 2018
BackgroundIntegrated care is recognised as an important enabler to healthy ageing, yet few countries have managed to sustainably deliver integrated care for older people.
Andrew M Briggs   +1 more
doaj   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

open access: yesFEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz   +9 more
wiley   +1 more source

Bilastine for the treatment of allergic rhinoconjunctivitis and urticaria: results from an international Delphi study

open access: yesDrugs in Context
Background: Second-generation oral H1-antihistamines, including bilastine, represent the emerging treatments of allergic rhinitis (including rhinoconjunctivitis) and chronic urticaria in both adults and children.
Giorgio Walter Canonica   +7 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

open access: yesFEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies   +3 more
wiley   +1 more source

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