Results 81 to 90 of about 1,660,494 (259)
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Plural Conjuncts and Syncretism Facilitate Gender Agreement in Serbo-Croatian:Experimental Evidence
Frontiers in Psychology, 2019 The literature on agreement in South Slavic generalizes that conjunct agreement in gender is only possible when all conjuncts are plural (e.g., Bošković, 2009). Marušič et al.
Ivana Mitić, Boban Arsenijević
doaj +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Determining the domain of attraction of hybrid non–linear systems using maximal Lyapunov functions [PDF]
, 2010 summary:In this article a method is presented to find systematically the domain of attraction (DOA) of hybrid non-linear systems. It has already been shown that there exists a sequence of special kind of Lyapunov functions $V_n$ in a rational functional ...
Hangos, Katalin M. +3 more
core +1 more source
Attraction between trapped ions and beams of electrons
AIP Advances, 2020 The attraction between 100 and 160 eV electron beams and a cloud of trapped calcium ions was observed experimentally. To explain the effect, analytical and numerical models were proposed. They are based on the well-known, classical, Rutherford scattering
Łukasz Kłosowski, Mariusz Piwiński
doaj +1 more source
Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens
FEBS Open Bio, EarlyView.Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
Great Barrier Reef intergovernmental agreement 2009 [PDF]
, 2009 The Commonwealth and Queensland Governments have long demonstrated their commitment to working together collaboratively for the long-term protection and conservation of the Great Barrier Reef ecosystem, to ensure it is preserved as an important feature ...
core
Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1
FEBS Open Bio, EarlyView.The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose +9 more
wiley +1 more source