Results 231 to 240 of about 756,348 (315)

A Humanized Anti‐gD Broadly Neutralizing Antibody Confers Complete Post‐Exposure Protection against Pseudorabies Virus

Advanced Science, EarlyView.
Pseudorabies virus (PRV), an emerging zoonotic α‐herpesvirus, causes life‐threatening human encephalitis. We identified a broad‐spectrum neutralizing antibody 6F7 targeting PRV gD. It blocks gD‐Nectin‐1 binding and membrane fusion, inhibiting replication across all PRV variants, representing a promising candidate for anti‐PRV therapy.
Yue Sun, Jianbo Liu, Shi‐Jia Xu, Meng‐Xin Wang, Hongliang Zhang, Yanhe Zhang, Zhi‐Jun Tian, Jin‐Mei Peng, Xin Yin, Tong‐Qing An, Xue‐Hui Cai, Yan‐Dong Tang   +11 more
wiley   +1 more source

The Effects of Land Management Policies on the Environment and People in Low- and Middle-Income Countries: A Systematic Review. [PDF]

Campbell Syst Rev
Marion P, Storhaug I, Lee S, Sempé L, Romero C, Gonzalez Parrao C, Snilstveit B.   +6 more
europepmc   +1 more source

PlantGFM: A Genomic Foundation Model for Discovery and Creation of Plant Genes

Advanced Science, EarlyView.
A plant genomic foundation model pre‐trained on 12 species enables both accurate gene prediction and de novo gene design. Through AI‐human knowledge screening, seven designed sequences showed transcriptional activity in plants, with two expressing stable proteins—demonstrating the first DNA‐RNA‐protein expression of LLM‐generated genes in plants and ...
Changhao Li, Qizhe Zhang, Hanchen Chen, Kepeng Lin, Chengfang Luo, Mengying Yang, Wei Xu, Fan Yao, Jianbing Yan, Qing‐Yong Yang, Xuehai Hu   +10 more
wiley   +1 more source

Training in metataxonomics-integrated risk assessment for foodborne pathogens in the Polish and Spanish dairy chain (DAIRYPOL). [PDF]

EFSA J
Bucka-Kolendo J, Fernández PS, Garcia-Gutierrez E.   +2 more
europepmc   +1 more source

Xenogeneic Mitochondrial Transplantation Improves Selected Age‐Associated Phenotypes in Mice

Advanced Science, EarlyView.
Yak‐derived xenogeneic mitochondrial transplantation improves selected age‐associated phenotypes in mice, enhances mitochondrial functional readouts, and engages host mitochondrial quality‐control pathways. Broad tissue biodistribution, increased ATP production and mtDNA copy number, reduced ROS levels and dysfunctional mitochondria, improved motility ...
Wenpeng Li, Xijia Wang, Yaning Hu, Zhen Yang, Tian Niu, Xingbo Zhao   +5 more
wiley   +1 more source

Dual-Role GH7 Family Proteins From Verticillium dahliae Function as Virulence Factors and Intracellular Effectors Triggering NLR-Mediated Immunity. [PDF]

Plant Cell Environ
Ji XB, Zhang QL, Liu XX, Wang XY, Zhang YD, Dai XF, Wang JL, Subbarao KV, Zhang DD, Hu XP, Chen JY.   +10 more
europepmc   +1 more source

Trap Depth Modulation and Antenna Effect of Organic Ligands for Enhancing Rare‐Earth Long Persistent Luminescence

Advanced Science, EarlyView.
Different from the current research trends that mainly focus on optimizing a single color system, a universal organic–inorganic hybrid strategy is proposed, aiming to synergistically enhance the luminescent properties of red, green, and blue multi‐color inorganic long‐persistent phosphorescent materials by trap depth modulation and antenna effect of ...
Ting Tan, Nian Li, Bangmin Liu, Hao Wang, Xia Huang, Yuanjin Chen, Zhonghao Wang, Chaolong Yang   +7 more
wiley   +1 more source

Governance of antimicrobial resistance in Central Africa (2015-2025): a systematic review of policies, One Health coordination and funding. [PDF]

JAC Antimicrob Resist
Kamsu GT, Djuikoue IC, Thumamo Pokam BD, Seugnou Nana CD, Ngandjui Yonga C, Mboupaing MG, Marehin MS, Makaya Danguil Nieko NP, Sanou Kue F, Banze Mewehu T, Tseuko D, Hironi S, Mboliyou MT, Gatse Bouya RA, Apalata TR, Antoine-Moussiaux N.   +15 more
europepmc   +1 more source

SuFEx‐Enabled Reprogramming of Flavonoids for Selective α‐Glucosidase Covalent Inhibition

Advanced Science, EarlyView.
Selective inhibition of intestinal α‐glucosidase remains limited by poor enzyme specificity and off‐target metabolic effects. Here, SuFEx click chemistry is used to reprogram natural flavonoids into covalent inhibitors with enhanced α‐glucosidase selectivity and controlled reactivity. This strategy enables effective regulation of carbohydrate digestion
Fengyu Guo, Liwei Zhang, Minlong Wang, Yanjin Du, Tianyu Zhang, Hao Chen, Jiazeng Sun, Yang Yu, Zude He, Jie An, Xiaoxu Zhang, Weilin Lin, Fazheng Ren, Pengjie Wang, Ping Liu   +14 more
wiley   +1 more source

What farmers think about using crop biotechnology to boost photosynthesis in rice and potato. [PDF]

Sci Rep
Menary J, Capell T, Rahaman EHMS, Hechanova SLS, Tallada AG, Fuller SS.   +5 more
europepmc   +1 more source