Results 31 to 40 of about 3,934 (114)

Proteomics and cytokine array jointly reveal the role of macrophage proinflammatory shift in liver fibrosis in dairy cows with ketosis

Journal of Animal Science and Biotechnology
Background Changes in macrophage function are crucial contributors to hepatic inflammation and fibrosis. However, the role of macrophages in the development of liver fibrosis in dairy cows with ketosis remains unclear.
Shiquan Zhu, Moli Li, Yihui Huo, Qiqi Cao, Zhaoju Deng, Kui Li, Yuxin He, Jian Gao, Chuang Xu   +8 more
doaj   +1 more source

A multi-epitope subunit vaccine providing broad cross-protection against diverse serotypes of Streptococcus suis

npj Vaccines
Streptococcus suis infection represents a major challenge in pig farming and public health due to its zoonotic potential and diverse serotypes, while existing vaccines lack effective cross-protection.
Jianan Liu, Zhen Zhang, Wanxia Pu, Xinming Pan, Pei Li, Qiankun Bai, Song Liang, Caiying Li, Yong Yu, Huochun Yao, Jiale Ma   +10 more
doaj   +1 more source

Intranasal delivery of a recombinant adenovirus vaccine encoding the PEDV COE elicits potent mucosal and systemic antibody responses in mice

Microbiology Spectrum
Porcine epidemic diarrhea virus (PEDV) is an enteropathogenic coronavirus that causes substantial economic loss to the global pig industry. The emergence of PEDV variants has increased the need for new vaccines, as commercial vaccines confer inferior ...
Shijie Yan, Yi Luo, Ningjia Zhan, Haoran Xu, Yao Yao, Xiang Liu, Xiaoqing Dong, Li Kang, Guozhong Zhang, Pinghuang Liu   +9 more
doaj   +1 more source

Glyceraldehyde-3-phosphate dehydrogenase from Eimeria acervulina modulates the functions of chicken dendritic cells to boost Th1 type immune response and stimulates autologous CD4+ T cells differentiation in-vitro

Veterinary Research, 2020
Dendritic cells (DCs) play a pivotal role to amplify antigen-specific immune responses. Antigens that sensitize T cells via antigen-presentation by DCs could enhance the capacity of host immunity to fight infections.
Shakeel Ahmed Lakho, Muhammad Haseeb, Jianmei Huang, Zhang Yang, Muhammad Waqqas Hasan, Muhammad Tahir Aleem, Muhammad Ali-ul-Husnain Naqvi, Muhammad Ali Memon, XiaoKai Song, RuoFeng Yan, Lixin Xu, XiangRui Li   +11 more
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Identification of two immunodominant and neutralizing linear B-cell epitopes exposed on the surface of the porcine deltacoronavirus spike protein

Veterinary Research
Porcine deltacoronavirus (PDCoV) is an enteropathogenic virus that causes severe diarrhea in pigs, particularly suckling piglets, and exhibits cross-species transmission with zoonotic potential. The S1 subunit of the viral spike (S) protein mediates cell
Xi Li, Huan Ye, Xinna Ge, Lei Zhou, Xin Guo, Jun Han, Yongning Zhang, Hanchun Yang   +7 more
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Hepatocellular carcinoma-associated antigen 59 of Haemonchus contortus modulates the functions of PBMCs and the differentiation and maturation of monocyte-derived dendritic cells of goats in vitro

Parasites & Vectors, 2019
Background Hepatocellular carcinoma-associated antigen 59 (HCA59), which is one of the most important excretory/secretory products of Haemonchus contortus (HcESPs), is known to have antigenic functions. However, its immunomodulatory effects on host cells
QiangQiang Wang, LingYan Wu, Muhammad Waqqas Hasan, MingMin Lu, WenJuan Wang, RuoFeng Yan, LiXin Xu, XiaoKai Song, XiangRui Li   +8 more
doaj   +1 more source

HcTTR: a novel antagonist against goat interleukin 4 derived from the excretory and secretory products of Haemonchus contortus

Veterinary Research, 2019
Haemonchus contortus (H. contortus) has evolved sophisticated evasion mechanisms to ensure their survival, including generating excretion and secretion products (ESPs) to regulate the secretion of host cytokines. Interleukin 4 (IL4) is a classic T-helper
XiaoWei Tian, MingMin Lu, WenJuan Wang, CaiWen Jia, Ehsan Muhammad, RuoFeng Yan, LiXin Xu, XiaoKai Song, XiangRui Li   +8 more
doaj   +1 more source

Development and Validation of an Agricultural Safety and Health Literacy Tool

Journal of Multidisciplinary Healthcare
Gyeong-Ye Lee,1 Ki-Soo Park1,2 1Department of Preventive Medicine, Institute of Medical Sciences, College of Medicine, Gyeongsang National University, Jinju, Republic of Korea; 2Department of Bio & Medical Big Data, Gyeongsang National University ...
Lee GY, Park KS
doaj  

Overexpression of outer membrane protein A (OmpA) increases aminoglycoside sensitivity in mycobacteria

BMC Microbiology
Background Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb) complex infection, is a leading cause of death worldwide from a single infectious agent. The emergence of drug resistance Mtb clinical strains makes the situation more serious.
Xiuling Ma, Huoming Li, Jiahong Ji, Lingyuan Zeng, Minghui Tang, Chengrui Lei, You Zuo, Hao Li   +7 more
doaj   +1 more source

Heterodimerization of PRRSV replicase membrane proteins nsp2 and nsp3 regulates their cytoplasmic tail binding to viral RdRp domain for sgRNA synthesis

Journal of Virology
Recruitment of viral RNA polymerase to replicase membrane proteins is a critical step for assembly of the replication and transcription complex (RTC) during the replication of positive-stranded RNA viruses.
Xueyan Liu, Yunhao Hu, Qiongqiong Zhou, Peng Gao, Yongning Zhang, Lei Zhou, Xinna Ge, Xin Guo, Jun Han, Hanchun Yang   +9 more
doaj   +1 more source