Gaussian Processes for Predictive QSAR Modeling of Chromatographic Processes
ABSTRACT Chromatography is a key unit operation in the biopharmaceutical manufacturing process used for protein purification and polishing. Design and optimization of these processes are resource‐intensive resulting from the complex combinatorial design space.
Harini Narayanan +7 more
wiley +1 more source
From compaction to coexistence: A review of chassis engineering for intelligent agricultural machinery in complex paddy field ecosystems. [PDF]
Tang Z, Chu P, Ding Z, Fang M.
europepmc +1 more source
Transfer Learning Approaches in Bioprocess Engineering: Opportunities and Challenges
ABSTRACT Transfer learning (TL) has recently emerged as a promising approach to overcoming one of the key limitations of bioprocess engineering: data scarcity. By leveraging knowledge from one bioprocess to another, TL allows existing models and data sets to be reused efficiently, accelerating process development, improving prediction accuracy, and ...
Daniel Barón Díaz +3 more
wiley +1 more source
Mechanical Properties and Parameter Optimization for the "Suitable Harvest" Stage of Vegetable Sweet Potato Shoot Tips in Mechanized Harvesting. [PDF]
Shen H +6 more
europepmc +1 more source
ABSTRACT Stem cell‐based therapies hold transformative potential for regenerative medicine, yet their progress is constrained by persistent variability in manufacturing and clinical performance. Conventional frameworks such as Quality by Design (QbD), though effective for drugs and biologics, struggle to accommodate the dynamic nature of living cell ...
Mee‐Hae Kim, Masahiro Kino‐oka
wiley +1 more source
Design of a portable machine for picking chamomile flowers. [PDF]
El-Moulaa MAMA, Zaalouk AK, Mahmoud WA.
europepmc +1 more source
Real‐Time Monitoring of In Vitro Transcription for Production of mRNA Using Raman Spectroscopy
Schematic depicting the workflow for model building and validation using Raman spectroscopy for real‐time monitoring of IVT. ABSTRACT The success of COVID‐19 mRNA vaccines showcased the transformative potential of this adaptable, plug‐and‐play, and rapid response platform.
Julia Puppin Chaves Fulber +4 more
wiley +1 more source
Effect of Climate Change on Food Industry Supply Chain Resilience in China on the Basis of Double Machine Learning Models. [PDF]
Jin S, Liu D, Huang L.
europepmc +1 more source
Raman Spectroscopy–Based Glucose Feed Control Automates Malic Acid Fermentation
Raman spectroscopy enables automated, closed‐loop glucose feeding for malic acid production with Ustilago trichophora. Online PLS regression of glucose and malic acid provides input for PID control to maintain 20 g/L glucose. The feed is dynamically adjusted and stopped in response to metabolic demand and product inhibition, demonstrating practical ...
Luca Antonia Grebe +8 more
wiley +1 more source

