Results 31 to 40 of about 553,355 (253)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Introducing a special issue: What lessons to be learnt from reindeer-herding research in Russia?

Pastoralism
This introductory paper outlines the aim and tasks of the special issue “Reindeer herding research: Crossing disciplinary and regional borders of biology and social science”.
Joachim Otto Habeck, Kirill V. Istomin
doaj   +1 more source

Prospects and constraints in smallholder farmers' adoption of multiple soil carbon enhancing practices in Western Kenya

Heliyon, 2020
Most smallholder farmers in sub-Saharan Africa (SSA) are adversely affected by low soil fertility, land degradation and climate change-related shocks such as drought. These problems lead to low productivity and low household income.
George Magambo Kanyenji, Willis Oluoch-Kosura, Cecilia Moraa Onyango, Stanley Karanja Ng'ang'a   +3 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

The fertilising potential of manure-based biogas fermentation residues: pelleted vs. liquid digestate

Heliyon, 2020
Spreading of manure on agricultural soils is a main source of ammonia emissions and/or nitrate leaching. It has been addressed by the European Union with the Directives 2001/81/EC and 91/676/EEC to protect the environment and the human health.
Fabio Valentinuzzi, Luciano Cavani, Carlo Porfido, Roberto Terzano, Youry Pii, Stefano Cesco, Claudio Marzadori, Tanja Mimmo   +7 more
doaj   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Impact of demonstration zone policy on agricultural science and technology innovation: evidence from China

Humanities & Social Sciences Communications, 2023
As driving forces in agricultural development, science and technology, along with innovation in agricultural science and technology, are crucial to food security and socioeconomic development.
Nannan Wang, Dengfeng Cui
doaj   +1 more source

Agroecology, technology, and stakeholder awareness: Implementing the UN Food Systems Summit call for action

iScience, 2023
Summary: The global food system must meet the increasing demand for food, fiber, and energy while reducing environmental impacts. The UN Food System Summit (UNFSS) has made a clear call to action for a global food systems transformation.
Siyan Zeng, Juan Li, Thomas Cherico Wanger   +2 more
doaj   +1 more source