Results 41 to 50 of about 30,759,123 (306)

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Impact of demonstration zone policy on agricultural science and technology innovation: evidence from China

Humanities & Social Sciences Communications, 2023
As driving forces in agricultural development, science and technology, along with innovation in agricultural science and technology, are crucial to food security and socioeconomic development.
Nannan Wang, Dengfeng Cui
doaj   +1 more source

Agroecology, technology, and stakeholder awareness: Implementing the UN Food Systems Summit call for action

iScience, 2023
Summary: The global food system must meet the increasing demand for food, fiber, and energy while reducing environmental impacts. The UN Food System Summit (UNFSS) has made a clear call to action for a global food systems transformation.
Siyan Zeng, Juan Li, Thomas Cherico Wanger   +2 more
doaj   +1 more source

The Science of Agriculture [PDF]

Nature, 1880
n ...
openaire   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Introducing a special issue: What lessons to be learnt from reindeer-herding research in Russia?

Pastoralism
This introductory paper outlines the aim and tasks of the special issue “Reindeer herding research: Crossing disciplinary and regional borders of biology and social science”.
Joachim Otto Habeck, Kirill V. Istomin
doaj   +1 more source

Biological removal of iron and sulfate from synthetic wastewater of cotton delinting factory by using halophilic sulfate-reducing bacteria

Heliyon, 2019
Industrial and agricultural wastewater treatment, which has the potential to cause serious risks to human health and the environment, has special importance at the lowest cost and highest efficiency such as biological processes to treat wastewater.
Mehrnoush Eskandari Torbaghan, Gholam Hossein Khalili Torghabeh   +1 more
doaj   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source