Results 41 to 50 of about 29,652,484 (306)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

open access: yesFEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill   +6 more
wiley   +1 more source

Impact of demonstration zone policy on agricultural science and technology innovation: evidence from China

open access: yesHumanities & Social Sciences Communications, 2023
As driving forces in agricultural development, science and technology, along with innovation in agricultural science and technology, are crucial to food security and socioeconomic development.
Nannan Wang, Dengfeng Cui
doaj   +1 more source

Agroecology, technology, and stakeholder awareness: Implementing the UN Food Systems Summit call for action

open access: yesiScience, 2023
Summary: The global food system must meet the increasing demand for food, fiber, and energy while reducing environmental impacts. The UN Food System Summit (UNFSS) has made a clear call to action for a global food systems transformation.
Siyan Zeng   +2 more
doaj   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

open access: yesFEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno   +3 more
wiley   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

open access: yesFEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan   +11 more
wiley   +1 more source

Biological removal of iron and sulfate from synthetic wastewater of cotton delinting factory by using halophilic sulfate-reducing bacteria

open access: yesHeliyon, 2019
Industrial and agricultural wastewater treatment, which has the potential to cause serious risks to human health and the environment, has special importance at the lowest cost and highest efficiency such as biological processes to treat wastewater.
Mehrnoush Eskandari Torbaghan   +1 more
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

open access: yesFEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks   +4 more
wiley   +1 more source

The first evidence of accumulation and avoidance behavior of macroinvertebrates in a forest soil spiked with human-made iron nanoparticles: A field experiment

open access: yesHeliyon, 2020
Both earthworms and terrestrial isopods have been used to evaluate the quality of contaminated soil by NPs. However, most experiments have been conducted in the laboratory and under greenhouse conditions.
Pérez-Hernández Hermes   +7 more
doaj   +1 more source

De novo synthesis of short‐chain aldehydes and hydrocarbons secreted by the brown marmorated stink bug Halyomorpha halys

open access: yesFEBS Open Bio, EarlyView.
The brown marmorated stink bug, Halyomorpha halys, mainly secretes 4‐oxo‐(E)‐2‐hexenal, (E)‐2‐decenal, dodecane and tridecane, a mixture representative of that released by many heteropterans. We demonstrated that H. halys can synthesise these secretory components de novo using dietary glucose.
Haruna Fujimori, Koji Noge
wiley   +1 more source

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