Results 51 to 60 of about 2,410,979 (348)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Genetically modified ecosystems: Innovative approaches in agriculture and their environmental impact [PDF]

BIO Web of Conferences
This article explores genetically modified ecosystems within the context of agriculture, focusing on the innovative approaches enabled by biotechnology and their environmental impact. Recent advancements in gene-editing techniques, as well as traditional
Rustamova Nodira, Inoyatova Sokhiba, Madazizova Dilfuza, Israilova Dildora, Israilov Shoolim   +4 more
doaj   +1 more source

Modelling spatial and inter-annual variations of nitrous oxide emissions from UK cropland and grasslands using DailyDayCent [PDF]

, 2017
This work contributes to the Defra funded projects AC0116: ‘Improving the nitrous oxide inventory’, and AC0114: ‘Data Synthesis, Management and Modelling’.
Anthony, S., Bell, M.J., Cardenas, L.M., Chadwick, D., Cloy, J.M., Datta, A., Fitton, N., Hastings, A., Kuhnert, M., McGeough, K.L., Rees, R.M., Smith, K., Smith, P., Thorman, R., Topp, C.F.E., Watson, C.J., Williams, J.   +16 more
core   +2 more sources

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Biotechnology Applications of Plant Callus Cultures

Engineering, 2019
In ethnopharmacology, and especially in traditional Chinese medicine, medicinal plants have been used for thousands of years. Similarly, agricultural plants have been used throughout the history of mankind.
T. Efferth
semanticscholar   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Reducing Biological Risks to Security: International Policy Recommendations for the Obama Administration [PDF]

, 2009
Summarizes discussions among biotechnology and life sciences experts on the risks of bioterrorism and threats to public health and agriculture.

core  

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Agricultural Biotechnology for Sustainable Agriculture and Rural Development

International Journal of Bio-Resource and Stress Management, 2023
Technology application that uses biological systems living organizing or their deriva­tives to make or modify products or processes for specific uses is known as Biotech­nology.
Shyamala A.
doaj