Results 21 to 30 of about 79,293 (290)

Antibodies Against Hypothalamus and Pituitary Gland in Childhood-Onset Brain Tumors and Pituitary Dysfunction

Frontiers in Endocrinology, 2020
Purpose: To detect the presence of antipituitary (APA) and antihypothalamus antibodies (AHA) in subjects treated for brain cancers, and to evaluate their potential association with pituitary dysfunction.Methods: We evaluated 63 patients with ...
Giuseppa Patti, Giuseppa Patti, Erika Calandra, Erika Calandra, Annamaria De Bellis, Annalisa Gallizia, Annalisa Gallizia, Marco Crocco, Marco Crocco, Flavia Napoli, Anna Maria Elsa Allegri, Hanan F. Thiabat, Hanan F. Thiabat, Giuseppe Bellastella, Maria Ida Maiorino, Maria Luisa Garrè, Stefano Parodi, Mohamad Maghnie, Mohamad Maghnie, Natascia di Iorgi, Natascia di Iorgi   +20 more
doaj   +1 more source

Levels and in vitro functional effects of circulating anti-hinge antibodies in melanoma patients receiving the immune checkpoint inhibitor pembrolizumab.

PLoS ONE, 2023
The efficacy of PD-1 monoclonals such as pembrolizumab can be modulated by the signals delivered via their Fc region. Tumour/inflammation associated proteases can generate F(ab')2 fragments of therapeutic monoclonals, and subsequent recognition of F(ab ...
Barry D Hock, Liping Goddard, Sean A MacPherson, Matthew Strother, David Gibbs, John F Pearson, Judith L McKenzie   +6 more
doaj   +1 more source

External Validation of Proposed American Heart Association Algorithm for Cardiovascular Screening Before Kidney Transplantation

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background Screening for cardiovascular disease is currently recommended before kidney transplantation. The present study aimed to validate the proposed algorithm by the American Heart Association (AHA‐2022) considering cardiovascular findings and ...
Marie Bodilsen Nielsen, Jonathan Nørtoft Dahl, Bente Jespersen, Per Ivarsen, Henrik Birn, Simon Winther   +5 more
doaj   +1 more source

Older adults’ perceptions of online physical exercise management

Frontiers in Public Health
The study addresses the challenges of digitally transforming physical exercises for older adults (aged more than 55 years) to be performed in virtual environments (during the COVID-19 pandemic) as a long-term proactive strategic initiative in response to
Judita Peterlin, Vlado Dimovski, Simon Colnar, Bojan Blažica, Anamarija Kejžar   +4 more
doaj   +1 more source

303 Investigation of the antibacterial and regenerative properties of a novel AHA dental coating for the treatment of deep caries

Journal of Clinical and Translational Science, 2023
OBJECTIVES/GOALS: Our objective is to investigate the antibacterial and regenerative properties of a novel AHA dental coating for the prevention and treatment of deep caries (cavities).
Sarah Asby, Erin Binne, Gannon Kehe, Pinky Kadur, Devika Dharmala, Michael Schurr, Chaitanya Puranik, Devatha P. Nair   +7 more
doaj   +1 more source

Acquired Hemophilia A: A Permanent Challenge for All Physicians

Medicines, 2022
Acquired hemophilia A (AHA) is a rare disease with a prevalence in Europe of 1.5 per million. This diagnosis is significantly delayed in about one-third of all cases, leading to deferred treatment.
Knut M. Nowak, Alexander Carpinteiro, Cynthia Szalai, Fuat H. Saner   +3 more
doaj   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Portable Low‐Field Magnetic Resonance Imaging in People With Human Immunodeficiency Virus

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The aging population of people with HIV (PWH) raises heightened concerns regarding accelerated aging and dementia. Portable, low‐field MRI (LF‐MRI) is an innovative technology that could enhance access and facilitate routine monitoring of PWH.
Annabel Sorby‐Adams, Malachi Keo, Jennifer Guo, Daire Daly, Richard Ahern, Kimon Zachary, Gregory Robbins, Rajesh T. Gandhi, Bragi Sveinsson, Adam de Havenon, Kevin N. Sheth, Otto Rapalino, Juan Eugenio Iglesias Gonzales, W. Taylor Kimberly, Shibani S. Mukerji   +14 more
wiley   +1 more source

Diagnostic Utility of the ATG9A Ratio in AP‐4–Associated Hereditary Spastic Paraplegia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Adaptor protein complex 4–associated hereditary spastic paraplegia (AP‐4‐HSP), a childhood‐onset neurogenetic disorder and frequent mimic of cerebral palsy, is caused by biallelic variants in the adaptor protein complex 4 (AP‐4) subunit genes (AP4B1 [for SPG47], AP4M1 [for SPG50], AP4E1 [for SPG51], and AP4S1 [for SPG52]).
Habibah A. P. Agianda, Hyo‐Min Kim, Nicole Battaglia, Joshua Rong, Amy Tam, Enrique Gonzalez Saez‐Diez, Cornelius F. Boerkoel, Afshin Saffari, Vicente Quiroz, Luca Schierbaum, Zainab Zaman, Katerina Bernardi, Darius Ebrahimi‐Fakhari   +12 more
wiley   +1 more source

Shape‐Morphing Nanoengineered Hydrogel Ribbons as Hemostats

Advanced Functional Materials, EarlyView.
This study introduces a self‐assembling, shape‐morphing nanoengineered hydrogel ribbon system that rapidly forms porous aggregates in situ for efficient hemostasis in trauma and surgical applications. Abstract Rapid and effective hemorrhage control remains a major challenge in trauma and surgical care, particularly for complex or noncompressible wounds.
Ryan Davis Jr, Saptarshi Biswas, Jacob Aragon, Asaf Dana, Jasmine Sureka, Vaaridhi Ramanuja, Jeevika Thazhaiselvam, Sarah E. Miller, Taylor H. Ware, Akhilesh K. Gaharwar   +9 more
wiley   +1 more source