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Afghanistan Journal of Basic Medical ScienceBackground: The extensive application of antibiotics for bacterial disease treatment has resulted in the emergence of antibiotic resistance and biofilm formation, a significant issue that contributes to increased illness and death rates. Quorum sensing (QS) is cell-cell communication in bacteria involved in the formation of biofilm in which this ...
Abdul Musawer Bayan
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Crystallization ofPseudomonas aeruginosaAHL synthase LasI using β-turn crystal engineering
Acta Crystallographica Section D Biological Crystallography, 2004In Gram-negative bacteria, intercellular communication and virulence regulation is mediated by the diffusible chemical signal acyl-homoserine-L-lactone (AHL). The AHL synthase enzymes produce a variety of AHLs from the substrates S-adenosyl-L-methionine and acyl-acyl carrier protein.
Ty A, Gould +4 more
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Chemosphere, 2019
Acyl-homoserine lactone (AHL)-based quorum sensing (QS) in the anaerobic ammonium oxidizing (anammox) consortia has attracted increasing attention. However, AHL synthase in anammox bacteria and the relationship between AHL synthetic genes and anammox activity are still not clear because anammox bacteria have not been isolated from the consortia.
Xi, Tang +4 more
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Acyl-homoserine lactone (AHL)-based quorum sensing (QS) in the anaerobic ammonium oxidizing (anammox) consortia has attracted increasing attention. However, AHL synthase in anammox bacteria and the relationship between AHL synthetic genes and anammox activity are still not clear because anammox bacteria have not been isolated from the consortia.
Xi, Tang +4 more
openaire +2 more sources
Afghanistan Journal of Basic Medical ScienceAbstract Multidrug-resistant specially in Pseudomonas aeruginosa is an emerging global health threat; thus, there is an increasing demand for anti-virulence strategies targeting bacterial communication rather than their growth. As a central enzyme in the quorum-sensing network, the LasI AHL synthase is a promising anti-virulence target.
Abdullah Ahmadzai +8 more
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Canadian Journal of Microbiology, 2009
One of the most important signal transduction pathways in bacteria, quorum sensing, is involved in many regulatory circuits in rhizobia, especially in the control of communication between rhizobia and their plant hosts. In this study, we identified 3 autoinducer synthase genes — mrlI1, mrlI2, and mrlI3 — in Mesorhizobium loti NZP 2213.
Menghua, Yang +5 more
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One of the most important signal transduction pathways in bacteria, quorum sensing, is involved in many regulatory circuits in rhizobia, especially in the control of communication between rhizobia and their plant hosts. In this study, we identified 3 autoinducer synthase genes — mrlI1, mrlI2, and mrlI3 — in Mesorhizobium loti NZP 2213.
Menghua, Yang +5 more
openaire +2 more sources
Afghanistan Journal of Basic Medical Science
Introduction: Misuse of antimicrobial agents and inadequate treatment methods lead to recurrent infections due to microorganism resistance, multi-drug resistance, and biofilm formation. Acyl-homoserine lactones propagate resistance and establish a stable microbial population.
Farhad Haidari +3 more
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Introduction: Misuse of antimicrobial agents and inadequate treatment methods lead to recurrent infections due to microorganism resistance, multi-drug resistance, and biofilm formation. Acyl-homoserine lactones propagate resistance and establish a stable microbial population.
Farhad Haidari +3 more
openaire +1 more source
Molecular Diversity
Antimicrobial resistance is posing a major threat to public health, thus contributing to a surge in treatment failure, prolonged infections, and rising mortality. In the present study, a multi-tier virtual screening approach was employed to identify marine-derived leads targeting the acyl-homoserine-lactone synthase (AHL), a promising drug target in ...
Atikulla Shaikh +7 more
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Antimicrobial resistance is posing a major threat to public health, thus contributing to a surge in treatment failure, prolonged infections, and rising mortality. In the present study, a multi-tier virtual screening approach was employed to identify marine-derived leads targeting the acyl-homoserine-lactone synthase (AHL), a promising drug target in ...
Atikulla Shaikh +7 more
openaire +2 more sources
AHL-Priming for Enhanced Resistance as a Tool in Sustainable Agriculture.
FEMS Microbiology Ecology, 2020Abhishek Shrestha, Adam Schikora
exaly
Crystallization of Pseudomonas aeruginosa AHL Synthase LasI Using β-Turn Crystal Engineering
Acta Crystallographica Section D: Biological Crystallography, 2004Kyoung-Hee Choi +2 more
exaly