Durable formulations of quorum quenching enzymes [PDF]
Scientific ReportsEnzymes with industrial potential often face limitations due to stability and longevity constraints. Thermostable quorum quenching lactonases are appealing biotechnology tools for controlling microbial pathogenicity and biofilm formation via the ...
Reed Jacobson +2 more
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Quorum Sensing and Quorum Quenching with a Focus on Cariogenic and Periodontopathic Oral Biofilms
Microorganisms, 2022 Numerous in vitro studies highlight the role of quorum sensing in the pathogenicity and virulence of biofilms. This narrative review discusses general principles in quorum sensing, including Gram-positive and Gram-negative models and the influence of ...
Patricia P Wright +1 more
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Quorum Quenching Agents: Resources for Antivirulence Therapy [PDF]
Marine Drugs, 2014 The continuing emergence of antibiotic-resistant pathogens is a concern to human health and highlights the urgent need for the development of alternative therapeutic strategies.
Kaihao Tang +2 more
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Quorum Quenching Revisited—From Signal Decays to Signalling Confusion
Sensors, 2012 In a polymicrobial community, while some bacteria are communicating with neighboring cells (quorum sensing), others are interrupting the communication (quorum quenching), thus creating a constant arms race between intercellular communication. In the past
Kar Wai Hong +2 more
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A Novel and Efficient Platform for Discovering Noncanonical Quorum-Quenching Proteins [PDF]
Microbiology Spectrum, 2023 Quorum sensing (QS) is a well-known chemical signaling system responsible for intercellular communication that is widespread in bacteria. Acyl-homoserine lactone (AHL) is the most-studied QS signal.
Jinxing Liao +7 more
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Quorum quenching by endophytic Bacillus cereus AL1: a lactonase-based anti-virulence strategy against Pseudomonas aeruginosa [PDF]
BMC MicrobiologyBackground Pseudomonas aeruginosa infections are often challenging to treat due to multiple drug resistance, besides the development of biofilms and a plethora of virulence factors regulated by quorum sensing.
Alaa A. Fawzy +3 more
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Quorum Sensing and Quorum Quenching in Periodontal Disease: Mechanisms and Therapeutic Potential [PDF]
Current Issues in Molecular BiologyPeriodontal disease is a chronic inflammatory condition driven by polymicrobial biofilms whose interaction with the host immune response drives the destruction of tooth-supporting tissues.
Nada Tawfig Hashim +8 more
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Quorum Quenching Approaches against Bacterial-Biofilm-Induced Antibiotic Resistance [PDF]
AntibioticsWith the widespread phenomenon of antibiotic resistance and the diffusion of multiple drug-resistant bacterial strains, enormous efforts are being conducted to identify suitable alternative agents against pathogenic microorganisms.
Patrizia D’Aquila +6 more
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Quorum-quenching microbial infections: mechanisms and implications [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2007 The discovery of antibiotics early in the past century marked the beginning of active control and prevention of infectious microbial diseases. However, extensive use of antibiotics has also unavoidably resulted in the emergence of ‘superbugs’ that resist conventional antibiotics.
Yi-Hu Dong +2 more
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Quorum sensing and self-quorum quenching in the intracellular pathogen Brucellamelitensis.
PLoS ONE, 2013 Brucella quorum sensing has been described as an important regulatory system controlling crucial virulence determinants such as the VirB type IV secretion system and the flagellar genes.
Matthieu Terwagne +5 more
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