Effects of combined oral contraceptives and metformin on paraoxonase 1 lactonase activity and status in patients with polycystic ovary syndrome and insulin resistance [PDF]
Frontiers in EndocrinologyObjectiveTo investigate the effects of combined oral contraceptives (COCs) and metformin treatment on the lactonase activity and status of paraoxonase 1 (PON1), and oxidative stress levels in patients with polycystic ovary syndrome (PCOS) and insulin ...
Jiagui Liang +20 more
doaj +2 more sources
The characterization of a new stabilized lactonase from the endophytic fungi Aspergillus pseudonomiae with anti-bacterial and anti-fungal properties. [PDF]
Protein SciAbstract Microorganisms use diverse small‐molecule signals to coordinate behavior, supporting interspecies and interkingdom communication. These chemical dialogs shape fundamental biological processes and define interactions from cooperation to antagonism.
Ben Tovim D +4 more
europepmc +2 more sources
Quorum quenching by endophytic Bacillus cereus AL1: a lactonase-based anti-virulence strategy against Pseudomonas aeruginosa [PDF]
BMC MicrobiologyBackground Pseudomonas aeruginosa infections are often challenging to treat due to multiple drug resistance, besides the development of biofilms and a plethora of virulence factors regulated by quorum sensing.
Alaa A. Fawzy +3 more
doaj +2 more sources
Marked Long-Term Improvement in Lung Function in Melanoma Differentiation-Associated Protein 5 Antibody-Positive Dermatomyositis Patients: Experience of a Single-Center Longitudinal Cohort in North America. [PDF]
Arthritis Care Res (Hoboken)Objective The objective of this study was to describe the longitudinal disease course and pulmonary outcomes of North American patients with melanoma differentiation–associated protein 5 (MDA5) antibody–associated dermatomyositis (DM). Methods Thirty patients with MDA5 antibody–associated DM were identified in a single‐center longitudinal cohort of 352
Cheah JX +8 more
europepmc +2 more sources
Identification and characterization of quorum-quenching enzyme AiiF from Acidithiobacillus ferrooxidans and its application for biofilm disruption [PDF]
Applied and Environmental MicrobiologyQuorum sensing-induced functions, including biofilm formation, can greatly influence biotechnology applications, including industrial metal bioleaching processes.
Mallori A. Herishko +2 more
doaj +2 more sources
β-Propeller structure of the CJ1041C protein from Campylobacter jejuni and its interaction with Ca2+ ions [PDF]
Scientific ReportsCampylobacter jejuni is the leading bacterial cause of foodborne enteric disease worldwide. The increasing emergence of antibiotic-resistant C. jejuni strains underscores the need to identify new protein targets for antibacterial drug development through
Min-Ah Park, Sung-il Yoon
doaj +2 more sources
Enzymatic quorum quenching alters the phyllosphere microbiome and suppresses a bacterial-induced plant disease [PDF]
Scientific ReportsBacterial plant pathogens cause hundreds of millions of dollars in annual crop losses in the United States alone, further stressing an already strained global food supply. Numerous bacteria in the phyllosphere use N-acyl homoserine lactone (AHL)-mediated
Qian Zhang +5 more
doaj +2 more sources
Effects of Signal Disruption Depends on the Substrate Preference of the Lactonase
Frontiers in Microbiology, 2020 Many bacteria produce and use extracellular signaling molecules such as acyl homoserine lactones (AHLs) to communicate and coordinate behavior in a cell-density dependent manner, via a communication system called quorum sensing (QS).
Rakesh Sikdar, Mikael Elias
exaly +3 more sources
Characterization of a Novel N-Acylhomoserine Lactonase RmmL from Ruegeria mobilis YJ3
Marine Drugs, 2018 Gram-negative bacteria utilize N-acylhomoserine lactones (AHLs) as quorum sensing (QS) signaling molecules for intercellular communication. Cell-to-cell communication depends on cell population density, and AHL-dependent QS is related to the production ...
Hu Shan, Yanfen Zheng, Min Yu
exaly +3 more sources
Plasma levels of adhesion molecules are elevated in dermatomyositis-interstitial lung disease and associated with low paraoxonase-1 activity [PDF]
Arthritis Research & TherapyObjective To evaluate circulating levels of intercellular cell adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) in patients with dermatomyositis (DM) and DM associated interstitial lung disease (DM-ILD).
Sangmee Sharon Bae +7 more
doaj +2 more sources