Molecules, 2022 The lactonase activity of paraoxonase 1 (PON1) has a crucial antiatherogenic function, and also serves as an important biochemical marker in human blood because the aberrant lactonase activity of PON1 is a key indicator for a number of diverse human ...
Ming Mao Gong +2 more
exaly +4 more sources
Effects of combined oral contraceptives and metformin on paraoxonase 1 lactonase activity and status in patients with polycystic ovary syndrome and insulin resistance [PDF]
Frontiers in EndocrinologyObjectiveTo investigate the effects of combined oral contraceptives (COCs) and metformin treatment on the lactonase activity and status of paraoxonase 1 (PON1), and oxidative stress levels in patients with polycystic ovary syndrome (PCOS) and insulin ...
Jiagui Liang +20 more
doaj +2 more sources
Quorum quenching by endophytic Bacillus cereus AL1: a lactonase-based anti-virulence strategy against Pseudomonas aeruginosa [PDF]
BMC MicrobiologyBackground Pseudomonas aeruginosa infections are often challenging to treat due to multiple drug resistance, besides the development of biofilms and a plethora of virulence factors regulated by quorum sensing.
Alaa A. Fawzy +3 more
doaj +2 more sources
Identification and characterization of quorum-quenching enzyme AiiF from Acidithiobacillus ferrooxidans and its application for biofilm disruption [PDF]
Applied and Environmental MicrobiologyQuorum sensing-induced functions, including biofilm formation, can greatly influence biotechnology applications, including industrial metal bioleaching processes.
Mallori A. Herishko +2 more
doaj +2 more sources
β-Propeller structure of the CJ1041C protein from Campylobacter jejuni and its interaction with Ca2+ ions [PDF]
Scientific ReportsCampylobacter jejuni is the leading bacterial cause of foodborne enteric disease worldwide. The increasing emergence of antibiotic-resistant C. jejuni strains underscores the need to identify new protein targets for antibacterial drug development through
Min-Ah Park, Sung-il Yoon
doaj +2 more sources
Enzymatic quorum quenching alters the phyllosphere microbiome and suppresses a bacterial-induced plant disease [PDF]
Scientific ReportsBacterial plant pathogens cause hundreds of millions of dollars in annual crop losses in the United States alone, further stressing an already strained global food supply. Numerous bacteria in the phyllosphere use N-acyl homoserine lactone (AHL)-mediated
Qian Zhang +5 more
doaj +2 more sources
Plasma levels of adhesion molecules are elevated in dermatomyositis-interstitial lung disease and associated with low paraoxonase-1 activity [PDF]
Arthritis Research & TherapyObjective To evaluate circulating levels of intercellular cell adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) in patients with dermatomyositis (DM) and DM associated interstitial lung disease (DM-ILD).
Sangmee Sharon Bae +7 more
doaj +2 more sources
Reproductive Biology and Endocrinology, 2023 Background Childbearing in women with advanced maternal age (AMA) has increased the need for artificial reproductive technology (ART). ART and oxidative stress are associated with many pregnancy complications.
Chenyu Jiang +5 more
doaj +1 more source
Antioxidants, 2023 Paraoxonase-1 (PON1) is an antioxidant enzyme associated with high-density lipoproteins (HDL). Reduced serum PON1 activity is found in diseases marked by oxidative stress and inflammation, but its role in obesity remains unclear.
Helena Castañé +10 more
doaj +1 more source
Use of Quorum Sensing Inhibition Strategies to Control Microfouling
Marine Drugs, 2021 Interfering with the quorum sensing bacterial communication systems has been proposed as a promising strategy to control bacterial biofilm formation, a key process in biofouling development. Appropriate in vitro biofilm-forming bacteria models are needed
Andrea Muras +3 more
doaj +1 more source