PON1 haplotypes show genotype-dependent associations with dysglycemia and metabolic liver risk beyond paraoxonase activity [PDF]
Frontiers in EndocrinologyIntroductionParaoxonase 1 (PON1) is a liver-derived HDL-associated enzyme with key antioxidant functions implicated in cardiometabolic disease.
Laura Batista-Herrera +13 more
doaj +2 more sources
Marked Long-Term Improvement in Lung Function in Melanoma Differentiation-Associated Protein 5 Antibody-Positive Dermatomyositis Patients: Experience of a Single-Center Longitudinal Cohort in North America. [PDF]
Arthritis Care Res (Hoboken)Objective The objective of this study was to describe the longitudinal disease course and pulmonary outcomes of North American patients with melanoma differentiation–associated protein 5 (MDA5) antibody–associated dermatomyositis (DM). Methods Thirty patients with MDA5 antibody–associated DM were identified in a single‐center longitudinal cohort of 352
Cheah JX +8 more
europepmc +2 more sources
Preferential inhibition of paraoxonase activity of human paraoxonase 1 by negatively charged lipids
Journal of Lipid Research, 2004 To determine the causes responsible for a preferential decrease of paraoxonase activity, which has been observed in the serum of patients with cardiovascular diseases, the inactivation or inhibition of paraoxonase 1 (PON1) by various endogenous factors ...
Dai-Eun Sok, Su Duy Nguyen
exaly +3 more sources
The Structure and Function of Paraoxonase-1 and Its Comparison to Paraoxonase-2 and -3
Molecules, 2020 Serum paraoxonase-1 (PON1) is the most studied member of the group of paraoxonases (PONs). This enzyme possesses three enzymatic activities: lactonase, arylesterase, and paraoxonase activity.
Ajda Taler-Verčič +2 more
exaly +3 more sources
Effect of Atorvastatin Combined With Herb-Partitioned Moxibustion on PON-1 in Patients With Atherosclerotic Cerebral Infarction: A Randomized Controlled Trial. [PDF]
Brain BehavAtorvastatin combined with herb‐partitioned moxibustion significantly improved oxidative stress markers, blood rheology, vascular physiological function, and overall clinical efficacy in patients with atherosclerotic cerebral infarction while maintaining a favorable safety profile.
An W +9 more
europepmc +2 more sources
Study the levels of Leptin, and Adiponectin with Paraoxonase in Obese Individuals (male & female)
Tikrit Journal of Pure Science, 2023 Obesity is a well-known risk factor of metabolic complications and cardiovascular disease. Associations between anthropometric measurements and fat distribution and risk factors for cardiovascular disease have been demonstrated in several populations.
Entedhar R. Sarhat
doaj +1 more source
Effect of Gluten-Free Diet on Serum Antioxidant Levels in Children with Celiac
European Journal of Biology, 2023 Objective: Celiac disease (CD) is an inflammatory condition of the small intestine triggered by the consumption of gluten. A strict gluten-free diet (GFD) is the only treatment that can eliminate CD complications. It was aimed to evaluate the effect of a
Mehmet Ali Gül +5 more
doaj +1 more source
Role of oxidant-antioxidant enzymes in managing the cardiovascular risks in nephrotic syndrome patients [PDF]
Journal of Nephropathology, 2022 Increased reactive oxygen species (ROS) in nephrotic syndrome (NS) are involved in the oxidation of membrane proteins, lipoproteins and several receptor molecules ultimately leading to their functional deficit.
Souparnika Sreelatha +3 more
doaj +1 more source
Bladder Cancer Chemosensitivity Is Affected by Paraoxonase-2 Expression
Antioxidants, 2020 The goal of the current study was to identify potential roles of paraoxonase-2 in bladder carcinogenesis. T24 bladder cancer cells were transfected with plasmids inducing paraoxonase-2 silencing or overexpression. Upon the selection of clones stably down-
Stefania Fumarola +10 more
doaj +1 more source
Slovenian Veterinary Research, 2023 Current findings aimed to find out camel milk's effects on lipid metabolism, expression of the genes for antioxidant enzymes and paraoxonase-1 (PON-1) activity in rats fed diet-containing cholesterol 1%. Therefore, 30 rats were divided into three groups
Sabry M. El-Bahr +2 more
doaj +1 more source