Bladder Cancer Chemosensitivity Is Affected by Paraoxonase-2 Expression [PDF]
Antioxidants, 2020 The goal of the current study was to identify potential roles of paraoxonase-2 in bladder carcinogenesis. T24 bladder cancer cells were transfected with plasmids inducing paraoxonase-2 silencing or overexpression. Upon the selection of clones stably down-
Andrea B Galosi +2 more
exaly +8 more sources
The Structure and Function of Paraoxonase-1 and Its Comparison to Paraoxonase-2 and -3 [PDF]
Molecules, 2020 Serum paraoxonase-1 (PON1) is the most studied member of the group of paraoxonases (PONs). This enzyme possesses three enzymatic activities: lactonase, arylesterase, and paraoxonase activity.
Ajda Taler-Verčič +2 more
doaj +5 more sources
Paraoxonase 1 and atherosclerosis
Frontiers in Cardiovascular Medicine, 2023 Paraoxonase 1 (PON1), residing almost exclusively on HDL, was discovered because of its hydrolytic activity towards organophosphates. Subsequently, it was also found to hydrolyse a wide range of substrates, including lactones and lipid hydroperoxides ...
P. Durrington, Bilal Bashir, H. Soran
semanticscholar +4 more sources
Paraoxonase 1 and Non-Alcoholic Fatty Liver Disease: A Meta-Analysis
Molecules, 2021 Oxidative stress is involved in the pathophysiology of nonalcoholic fatty liver disease (NAFLD). However, reliable biomarkers of NAFLD in relation to oxidative stress are not available.
Kazuhiko Kotani +3 more
doaj +2 more sources
Marked Long-Term Improvement in Lung Function in Melanoma Differentiation-Associated Protein 5 Antibody-Positive Dermatomyositis Patients: Experience of a Single-Center Longitudinal Cohort in North America. [PDF]
Arthritis Care Res (Hoboken)Objective The objective of this study was to describe the longitudinal disease course and pulmonary outcomes of North American patients with melanoma differentiation–associated protein 5 (MDA5) antibody–associated dermatomyositis (DM). Methods Thirty patients with MDA5 antibody–associated DM were identified in a single‐center longitudinal cohort of 352
Cheah JX +8 more
europepmc +2 more sources
Preferential inhibition of paraoxonase activity of human paraoxonase 1 by negatively charged lipids
Journal of Lipid Research, 2004 To determine the causes responsible for a preferential decrease of paraoxonase activity, which has been observed in the serum of patients with cardiovascular diseases, the inactivation or inhibition of paraoxonase 1 (PON1) by various endogenous factors ...
Dai-Eun Sok, Su Duy Nguyen
exaly +3 more sources
Serum paraoxonase 1 activity and protein N-homocysteinylation in primary human endometrial cancer
Tumor Biology, 2018 Paraoxonase 1 plays an important role in protection from oxidative stress and also decomposes homocysteine thiolactone, the toxic metabolite of homocysteine.
Krzysztof Gałczyński +5 more
doaj +2 more sources
Effect of Atorvastatin Combined With Herb-Partitioned Moxibustion on PON-1 in Patients With Atherosclerotic Cerebral Infarction: A Randomized Controlled Trial. [PDF]
Brain BehavAtorvastatin combined with herb‐partitioned moxibustion significantly improved oxidative stress markers, blood rheology, vascular physiological function, and overall clinical efficacy in patients with atherosclerotic cerebral infarction while maintaining a favorable safety profile.
An W +9 more
europepmc +2 more sources
International Journal of Molecular Sciences, 2022 Oral squamous cell carcinoma represents the most aggressive and frequent form of head and neck cancer. Due to drug resistance, the 5-year survival rate of patients with advanced disease is less than 50%.
R. Campagna +12 more
semanticscholar +1 more source
The Relationship between Cancer and Paraoxonase 1
Antioxidants, 2022 Extensive research has been carried out to understand and elucidate the mechanisms of paraoxonase 1 (PON1) in the development of diseases including cancer, cardiovascular diseases, neurological diseases, and inflammatory diseases.
I. Medina-Díaz +7 more
semanticscholar +1 more source