PON1 and Mediterranean Diet [PDF]
Nutrients, 2015 The Mediterranean diet has been proven to be highly effective in the prevention of cardiovascular diseases. Paraoxonase 1 (PON1) has been implicated in the development of those conditions, especially atherosclerosis. The present work describes a systematic review of current evidence supporting the influence of Mediterranean diet and its constituents on
Maria Ángeles Navarro Ferrando +2 more
exaly +5 more sources
Liver-specific paraoxonase-1 alleviates regulatory T cell-driven immunosuppression via metabolic reprogramming in hepatocellular carcinoma [PDF]
Nature CommunicationsParaoxonase-1 (PON1) is specifically expressed in the liver and has crucial effects on various liver diseases. The functions and underlying mechanisms of PON1 in hepatocellular carcinoma (HCC) remain unclear.
Zhou Lu +17 more
doaj +2 more sources
Paraoxonase 1 Suppresses Hepatocellular Carcinoma Progression by Modulating the NOD-like Receptor Signaling Pathway [PDF]
BiomoleculesHepatocellular carcinoma (HCC) represents one of the most lethal malignancies worldwide and is characterized by profound metabolic reprogramming during its development.
Hao-Lin Wei +5 more
doaj +2 more sources
Developmental Changes in PON1 Enzyme Activity in Young Children and Effects of PON1 Polymorphisms
Environmental Health Perspectives, 2009 Paraoxonase 1 (PON1) is an enzyme that detoxifies activated organophosphorus pesticides (OPs) and is also involved in oxidative stress pathways.PON1 activity in newborns is lower than in adults, but the ontogeny of PON1 activity is poorly characterized in young children.
Kim Harley +2 more
exaly +5 more sources
Paraoxonase-1 activity and AOPP levels in patients with type 2 diabetes mellitus [PDF]
Journal of Medical BiochemistryBackground: Paraoxonase 1 (PON1) is a calcium-dependent esterase and exerts antioxidant and antiatherogenic properties. Advanced oxidation protein products (AOPP) are a group of carbonylated protein products showing oxidant-mediated protein damage.
Oztürk Emre Hümeyra +2 more
doaj +2 more sources
Expression of paraoxonase 1 in HEK293 cells and its effect on lactonase and arylesterase activity in samples containing human serum and/or prooxidant or antioxidant agents - a preliminary study [PDF]
Acta Poloniae Pharmaceutica, 2023 Expression of recombinant paraoxonase 1 (PON1) in the human embryonic kidney (HEK293F) cell line was evaluated. Two recombinant human PON1 proteins were investigated: PON1-Fc, which has an Fc-tag on its C-terminal, and His-PON1-Fc, which has an Fc-tag on
Anna Bizoń, Agnieszka Piwowar
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The associations of PON1 and APOE polymorphisms with plasma lipid levels and the risk for late complications in type 2 diabetes patients [PDF]
Journal of Medical Biochemistry, 2023 Background: Besides good glycemic control, also control of lipid levels can effectively prevent or delay late type 2 diabetes (T2D) complications. As apolipoprotein E (APOE) and paraoxonase 1 (PON1) were shown to suppress atherosclerosis, we investigated
Klen Jasna, Goričar Katja, Dolžan Vita
doaj +1 more source
Epigenetics, 2022 Epigenome-wide association studies (EWAS) are widely implemented in epidemiology, and the Illumina HumanMethylationEPIC BeadChip (EPIC) DNA microarray is the most-used technology. Recently, next-generation sequencing (NGS)-based methods, which assess DNA
Dennis Khodasevich +5 more
doaj +1 more source
Vutiglabridin Modulates Paraoxonase 1 and Ameliorates Diet-Induced Obesity in Hyperlipidemic Mice
Biomolecules, 2023 Vutiglabridin is a clinical-stage synthetic small molecule that is being developed for the treatment of obesity and its target proteins have not been fully identified.
Dawoud Sulaiman +9 more
doaj +1 more source
Associations between PON1 enzyme activities in human ovarian follicular fluid and serum specimens. [PDF]
PLoS ONE, 2017 The importance of high-density lipoprotein (HDL) particle components to reproduction is increasingly recognized, including the constituent paraoxonase 1 (PON1).
Keewan Kim +3 more
doaj +1 more source