Results 41 to 50 of about 9,907 (172)

Digital Biomarkers for Precision Early Detection of Lung Cancer: Integrating AI‐Driven Multi‐Omics Into Clinical Pathways

Cancer Medicine, Volume 15, Issue 2, February 2026.
ABSTRACT Background Lung cancer remains the leading cause of cancer‐related mortality worldwide, highlighting the urgent need for earlier detection within real‐world screening and patient management pathways. Recent advances in multi‐omics technologies have created new opportunities for identifying biomarkers associated with early‐stage lung cancer ...
Fan Bu, Zhi‐Qiang Ling
wiley   +1 more source

The PON1 gene and detoxication

, 2000
It has been assumed since its discovery that serum paraoxonase (PON1) plays a major role in the detoxication of specific organophosphorus compounds.
Li, W. F, Richter, R. J, Costa, L. G., Shih, D. M, Jarvik, G. P, Furlong, C. E, Lusis, A. J, Brophy, V. H   +7 more
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PON1 arylesterase activity in the healthy subjects and the ACS patients and based on their PON1 55 genotype.

, 2015
The PON1 L55M genotype was determined by RT-PCR. PON1 arylesterase activity was measured by the increase in absorbance at 270 using phenylacetate as a substrate.
Pamela Camponova (779670), Abdelghani Bounafaa (779663), Abdelouahed Khalil (3826456), Abdelkhalid Essamadi (779673), Hicham Berrougui (779664), Najoua Yamoul (779671), Abderrahmane Moujahid (779668), Abdallah Bagri (779667), Olivier Kamtchueng Simo (779672), Noreddine Ghalim (779665), Souad Ikhlef (779669), Boubker Nasser (779666)   +11 more
core   +1 more source

PON1 arylesterase activity in the healthy subjects and the ACS patients and based on their PON1 192 genotype.

, 2015
The PON1 Q192R genotype was determined by RT-PCR. PON1 arylesterase activity was measured by the increase in absorbance at 270 using phenylacetate as a substrate.
Pamela Camponova (779670), Abdelghani Bounafaa (779663), Abdelouahed Khalil (3826456), Abdelkhalid Essamadi (779673), Hicham Berrougui (779664), Najoua Yamoul (779671), Abderrahmane Moujahid (779668), Abdallah Bagri (779667), Olivier Kamtchueng Simo (779672), Noreddine Ghalim (779665), Souad Ikhlef (779669), Boubker Nasser (779666)   +11 more
core   +1 more source

The effect of the paraoxonase 1 (PON1) T(−107)C polymorphism on serum PON1 activity in women is dependent on fatty acid intake [PDF]

, 2016
Paraoxonase 1 (PON1) is an enzyme that prevents the peroxidation of lipoprotein and cell membranes. Our hypothesis is that the effect of the PON1 T(−107)C polymorphism on serum PON1 activity in healthy adult women is dependent on their fatty acid intake ...
Vale, Sandra C., Crespo-Ribeiro, José A., Santos, Fabiola G., Becker, Maitê K., Garcia, Driele N., Barros, Carlos C., Corrêa, Vanessa S., Schneider, Augusto   +7 more
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PON1 55 and PON1 192 carrier frequencies of the 205 ACS patients.

, 2015
χ2 = 2.83, d.f. = 2, p = 0.09 for comparisons between the ACS diagnosis and PON192 carriers, and χ2 = 17.2, d.f. = 2, p = 0.0002 for comparisons between the ACS diagnosis and PON55 carriersPON1 55 and PON1 192 carrier frequencies of the 205 ACS patients.
Pamela Camponova (779670), Abdelghani Bounafaa (779663), Abdelouahed Khalil (3826456), Abdelkhalid Essamadi (779673), Hicham Berrougui (779664), Najoua Yamoul (779671), Abderrahmane Moujahid (779668), Abdallah Bagri (779667), Olivier Kamtchueng Simo (779672), Noreddine Ghalim (779665), Souad Ikhlef (779669), Boubker Nasser (779666)   +11 more
core   +1 more source

Relationship between DING proteins concentration, PON1 status and cholesterol.

, 2012
Correlation of DING proteins concentration with: (A) serum PON1 concentrations, (B) PON1 lactonase activity, (C) PON1 paraoxonase activity and (D) cholesterol concentration in HIV-infected patients.
Eric Chabriere (128709), Guillaume Gotthard (128706), Gerard Aragonès (179537), Nune Darbinian (179540), Mikael Elias (128712), Daniel Gonzalez (376967), Raúl Beltrán-Debón (179550), Olivier Rohr (9127), Jorge Joven (179582), Christian Schwartz (179570), Ahmed Djeghader (179534), Anna Rull (179562), Julien Hiblot (128703), Anabel García-Heredia (179545), Jordi Camps (179587), Carlos Alonso-Villaverde (179575), Rafal Kaminski (179554)   +16 more
core   +1 more source

Gene-environemnt interactions: paraoxonase (PON1) and sensitivity to organophosphate toxicity

, 2006
Paraoxonase (PON1) is a liver and plasma enzyme that hydrolyzes the active metabolites of several organophosphorus insecticides, PON1 displays several polymorphisms that influence both its level of expression and its catalytic activity, thereby ...
FURLONG CE, COLE TB, COSTA, Lucio Guido
core   +1 more source

Associations between PON1 enzyme activities in human ovarian follicular fluid and serum specimens. [PDF]

, 2017
The importance of high-density lipoprotein (HDL) particle components to reproduction is increasingly recognized, including the constituent paraoxonase 1 (PON1).
Browne Richard W., Michael S Bloom, Richard W Browne, Victor Y Fujimoto, Bloom Michael S., Keewan Kim, Kim Keewan, Fujimoto Victor Y.   +7 more
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Polymorfismus allel lidské paraoxonasy (PON1) a hemodialýza

, 2008
Allelický polymorfismus lidské paroxonasy a hemodialýza Renata Dvořáková ABSTRAKT Nemocní léčení hemodialýzou (HD) mají vysoké riziko koronárního onemocnění. Lidská paraoxonasa (PON1, EC 3.1.8.1) je enzym asociovaný s lipoproteinem o vysoké hustotě (HDL),
Dvořáková, Renata
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