Results 41 to 50 of about 6,713 (180)
Blood‐based proteomic signature of amyloidosis: identification of novel regulators of amyloid load
Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.Abstract INTRODUCTION Cerebral amyloidosis is a defining feature of Alzheimer's disease (AD), yet the molecular heterogeneity among amyloidbeta‐positive (Aβ+) individuals remains poorly defined. We aimed to map the proteomic correlates of cerebral amyloidosis and link them to clinical variability within Aβ+ individuals.
Yike Chen +18 more
wiley +1 more source
Paraoxonase 1 as an important antiatherogenic agent
Journal of Education, Health and Sport, 2019 The inverse relationship between High Density Lipoproteins (HDL) level and risk of ischaemic heart disease was proved by many epidemiological studies. Although the main mechanism of antiatherogenic activity of HDL is a reverse transport of cholesterol ...
Ewa Lidia Krzewicka-Romaniuk +3 more
doaj +1 more source
Food Science &Nutrition, Volume 14, Issue 6, June 2026.Aerial (leaves and flowers) and belowground (bulbs and roots) parts of Galanthus elwesii were extracted using water, 70% ethanol, and 80% methanol. Phytochemical analyses revealed organ‐ and solvent‐dependent variations in total phenolic and flavonoid contents, which were associated with differences in in vitro antioxidant activity determined by DPPH ...
Osman Ertan, Arif Ayar, Ebru Batı Ay
wiley +1 more source
Psychiatry and Clinical Neurosciences Reports, Volume 5, Issue 2, June 2026.We performed longitudinal evaluation using magnetic resonance imaging (MRI) and dopamine transporter single‐photon emission computed tomography (DAT‐SPECT) in a case of organophosphate‐induced toxic parkinsonism. Fluid‐attenuated inversion recovery (FLAIR) images showed bilateral striatal hyperintensity in the acute phase, followed by reduction of ...
Shuhei Nakao +6 more
wiley +1 more source
Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.Current bladder cancer therapies can cause toxicity and bladder dysfunction. Brief intravesical‐like aripiprazole exposure reduced bladder cancer cell viability and was associated with redox stress and caspase‐3 activation, while ex vivo findings suggested preserved bladder structure and function, warranting further investigation as a potential ...
Liam A. O'Callaghan +3 more
wiley +1 more source
Diabetic Medicine, Volume 43, Issue 6, June 2026.Abstract Introduction Type 2 diabetes is a complex condition with a multifactorial pathogenesis. The pathogenesis is considered to be polygenic due to complex interactions between genetic/epigenetic and environmental factors. The aim of this study is to determine the genetic, environmental and lifestyle factors associated with the development of type 2
Sunny Chinenye +18 more
wiley +1 more source
Effect of cigarette smoking on paraoxonase 1 activity according to PON1 L55M and PON1 Q192R gene polymorphisms [PDF]
Environmental Health and Preventive Medicine, 2011 Este estudio tiene como objetivo investigar el efecto del tabaquismo sobre la actividad de la paraoxonasa 1 (PON1) de acuerdo con los polimorfismos de los genes PON1 L55M y PON1 Q192R. Nuestra muestra incluyó 300 sujetos voluntarios: 138 no fumadores y 162 fumadores actuales de 38,47 ± 21,91 y 35,55 ± 16,03 años, respectivamente.
Dhouha Haj Mouhamed +8 more
openaire +2 more sources
The FASEB Journal, Volume 40, Issue 10, 31 May 2026.Multi‐omics profiling uncovers the effect of sex and mitochondrial‐haplotype on molecular fingerprints of aging in plasma. ABSTRACT The effect of mitochondrial‐haplotype (mt‐haplotype) on aging was studied using a unique rat model (OKC‐HETB/W), which has a heterogenous nuclear background combined with mitochondria from either Brown Norway (B‐haplotype)
Hoang Van M. Nguyen +13 more
wiley +1 more source
Egyptian Journal of Medical Human Genetics, 2021 Background Coronary artery disease (CAD) is a leading cause of morbidity and mortality, with a shifting trend towards the younger population. Paraoxonase1 (PON1) is a glycoprotein enzyme associated with high-density lipoprotein (HDL) particles in the ...
Rohit Kumar +5 more
doaj +1 more source
The number of PON1 mutant alleles, but not PON1 phenotype, is associated with Gensini score of coronary damage [PDF]
Romanian Review of Laboratory Medicine, 2013 Obiective. Scopul acestui studiu a fost de a examina efectele polimorfismelor (SNPs) genei PON1 la nivelul regiunii promotor (-909 şi -832) şi a primului exon (+575, 20352A>G, rezultând substituirea Q192R) asupra activităţilor paraoxonazei-1 (PON1) într-un grup format din 53 de pacienţi cu boală coronariană (CHD) dovedită angiografic şi 17 subiecţi ...
Ilea Irina +4 more
openaire +2 more sources