Results 41 to 50 of about 20,745 (266)

Paraoxonase-1 is related to inflammation, fibrosis and PPAR delta in experimental liver disease [PDF]

, 2009
Background Paraoxonase-1 (PON1) is an antioxidant enzyme synthesized by the liver. It protects against liver impairment and attenuates the production of the pro-inflammatory monocyte chemoattractant protein-1 (MCP-1).
Judit Marsillach, Jordi Camps, Natàlia Ferré, Raul Beltran, Anna Rull, Bharti Mackness, Michael Mackness, Jorge Joven, M Parola, I Leviev, L Rodrigo, BN La Du, N Ferré, N Ferré, J Marsillach, C Zhang, B Ustundag, KJ Simpson, C Daly, MJ Czaja, J Marsillach, B Coll, JP Iredale, MJ Arthur, W Jiménez, N Ferré, M Gassó, O Khersonsky, L Gaidukov, J Marsillach, AB Goulter, H Chung, R Bataller, KK Kharbanda, K Hensley, M Parola, E Zamara, M Czaja, F Marra, T Tabata, F Marra, E Zamara, M Parola, B Mackness, M Navab, C Fürnsinn, Y Fan, M Pesant, M Cabré, XP Yang, M Karin, M Aviram, M Aviram, B Li   +53 more
core   +2 more sources

The Association between PON1 (Q192R and L55M) Gene Polymorphisms and Risk of Cancer: A Meta-Analysis Based on 43 Studies

BioMed Research International, 2019
Q192R and L55M polymorphism were considered to be associated with the development of multiple cancers. Nevertheless, the results of these researches were inconclusive and controversial. Therefore, we conducted a meta-analysis of all eligible case-control
Xiaolan Pan, Lei Huang, Meiqin Li, Dan Mo, Yihua Liang, Zhiming Liu, Zhaodong Huang, Lingsha Huang, Jinfeng Liu, Bo Zhu   +9 more
semanticscholar   +1 more source

PON1 multitasks to protect health [PDF]

Proceedings of the National Academy of Sciences, 2008
The enzyme paraoxonase 1 (PON1) is an excellent example of a multitasking protein, displaying at least two very important functions: hydrolysis of organophosphorus (OP) anticholinesterases and prevention of oxidation of low density lipoproteins (LDLs) and high density lipoproteins (HDLs).
openaire   +2 more sources

Effect of PON1 on dichlorvos toxicokinetics [PDF]

Emergency Medicine Journal, 2010
To provide toxicokinetic and clinical evidence of the hydrolytic effect of paraoxonase-1 (PON1) on acute organophosphate poisoning in rats.40 male Wistar rats were randomised into four equal groups. Dichlorvos administration group (A group) underwent dichlorvos injection (dissolved in corn oil) using intraperitoneal (ip) dose of 10 mg/kg.
Wang, Na-Na, Yuan, Li, Dai, Heng, Han, Zhen-Kun, Zhao, Min   +4 more
openaire   +2 more sources

Paraoxonase-1 status in patients with hereditary hemochromatosis

Journal of Lipid Research, 2013
Hereditary hemochromatosis (HH) is characterized by accumulation of iron, oxidative stress, inflammation, and fibrogenesis in liver tissue. In this setting, research on the protection afforded by intracellular antioxidants is of clinical relevance ...
Nicola Martinelli, Anabel García-Heredia, Helena Roca, Núria Aranda, Victoria Arija, Bharti Mackness, Michael Mackness, Fabiana Busti, Gerard Aragonès, Juan Pedro-Botet, Federica Pedica, Ivana Cataldo, Judit Marsillach, Jorge Joven, Domenico Girelli, Jordi Camps   +15 more
doaj   +1 more source

Paraoxonase 2 overexpression inhibits tumor development in a mouse model of ovarian cancer. [PDF]

, 2018
Ovarian cancer (OC) is most lethal malignancy among all gynecological cancer. Large bodies of evidences suggest that mitochondrial-derived ROS play a critical role in the development and progression of OC.
Devarajan, Asokan, Farias-Eisner, Gina, Farias-Eisner, Robin, Fogelman, Alan M, Gao, Feng, Grijalva, Victor, Nwokedi, Josephine, Reddy, Srinivasa T, Su, Feng, Trost, Hannah, Yalamanchi, Ashna, Yalamanchi, Meghna   +11 more
core   +3 more sources

Paraoxonase-1 Serum Concentration and PON1 Gene Polymorphisms: Relationship with Non-Alcoholic Fatty Liver Disease

Journal of Clinical Medicine, 2019
Background: Non-alcoholic fatty liver disease (NAFLD) is an important cause of chronic liver diseases around the world. Paraoxonase-1 (PON1) is an enzyme produced by the liver with an important antioxidant role. The aim of this study was to evaluate PON1
M. Milaciu, Ș. Vesa, I. Bocșan, L. Ciumărnean, D. Sâmpelean, V. Negrean, R. Pop, D. Matei, Sergiu Pasca, A. Rãchişan, A. Buzoianu, M. Acalovschi   +11 more
semanticscholar   +1 more source

Atherothrombosis and Oxidative Stress: Mechanisms and Management in Elderly [PDF]

, 2017
Significance: The incidence of cardiovascular events (CVEs) increases with age, representing the main cause of death in an elderly population. Aging is associated with overproduction of reactive oxygen species (ROS), which may affect clotting and ...
Carnevale, Roberto, Loffredo, Lorenzo, Pastori, Daniele, Pignatelli, Pasquale, Violi, Francesco   +4 more
core   +1 more source

PON1 concentration and high-density lipoprotein characteristics as cardiovascular biomarkers

Archives of medical sciences. Atherosclerotic diseases, 2019
Introduction Serum paraoxonase 1 (PON1) is now known to be related to cardiovascular diseases (CVD). The aim of this study was to determine the relationship between PON1 concentration and high-density lipoprotein (HDL) subclasses in patients with proven ...
Fátima E. Murillo González, N. Ponce-Ruíz, A. Rojas-García, Y. Y. Bernal-Hernández, M. Mackness, J. Ponce-Gallegos, G. Cardoso-Saldaña, E. Jorge-Galarza, M. Torres-Tamayo, I. Medina-Díaz   +9 more
semanticscholar   +1 more source

Decreased paraoxonase-1 activity is associated with alterations of high-density lipoprotein particles in chronic liver impairment [PDF]

, 2010
Background Paraoxonase-1 (PON1), a lactonase synthesized by the liver, circulates in blood bound to high-density lipoproteins (HDL). This enzyme is thought to degrade oxidized phospholipids and play an important role in the organism's antioxidant and ...
Judit Marsillach, Gerard Aragonès, Bharti Mackness, Michael Mackness, Anna Rull, Raúl Beltrán-Debón, Juan Pedro-Botet, Carlos Alonso-Villaverde, Jorge Joven, Jordi Camps   +9 more
core   +2 more sources