Results 41 to 50 of about 16,258 (219)

PON1 hypermethylation is associated with progression of renal cell carcinoma

Journal of Cellular and Molecular Medicine, 2019
In this study, our aim was to exploring the influences of DNA methylation of PON1 on cell proliferation, migration and apoptosis of renal cancer cells. The genome‐wide methylation array of renal cell carcinoma samples and adjacent tissues were obtained ...
Xin Li, Qian Yu
semanticscholar   +1 more source

OP-hydrolyzing activity of the rh-PON1 enzymes.

, 2016
(A) compares the Pxn-hydrolyzing activity of the recombinant enzymes. The Pxn-hydrolyzing activity was determined using direct assay. Equal amounts of the rh-PON1 enzymes were incubated with 1 mM paraoxon in the activity buffer (50 mM Tris-HCl, pH 8.0 ...
Priyanka Bajaj (1786471), Rameshwar Prajapati (759424), Abhay T. Sangamwar (607386), Geetika Aggarwal (2141785), A. R. Satvik Iyengar (2141788), Rajan K. Tripathy (2141791), Abhay H. Pande (224367)   +6 more
core   +1 more source

Paraoxonase (PON1) phenotype is a better predictor of vascular disease than is PON1(192) or PON1(55) genotype

, 2000
—The paraoxonase (PON1) PON1-Q192R and PON1-L55M polymorphisms have been inconsistently associated with vascular disease. Plasma PON1 activity phenotypes vary markedly within genotypes and were, therefore, expected to add to the informativeness of ...
Thomas S. Hatsukami, Gail Pairitz Jarvik, Laura S. Rozek, Gerard D. Schellenberg, Rebecca J. Richter, Clement E. Furlong, Victoria H. Brophy   +6 more
core   +1 more source

Organophosphate pesticides and PON1 L55M in Parkinson's disease progression

Environment International, 2017
Background Parkinson's disease (PD) has motor and non-motor features that contribute to its phenotype and functional decline. Organophosphate (OP) pesticides and PON1 L55M, which influences OP metabolism, have been implicated in multiple mechanisms ...
K. Paul, J. Sinsheimer, M. Cockburn, J. Bronstein, Y. Bordelon, B. Ritz   +5 more
semanticscholar   +1 more source

Expression of human paraoxonase (PON1) during development

, 2003
Background Paraoxonase (PON1), a HDL-associated enzyme, protects against toxicity from specific organophosphorus compounds and oxidized lipids. Common polymorphisms in the PON1 gene have been identified and characterized in the coding region, 5 ...
ARNDT TL, RICHTER RJ, FURLONG CE, JAMPSA RL, COLE TB, JACK RM, WALTER BJ, TWARD A, SHIH DM, LUSIS AJ, COSTA, Lucio Guido   +10 more
core   +1 more source

Moderate dyslipoproteinemia induced inflammation and remodeling HDL and VLDL particles in post-renal transplant patients

Current Issues in Pharmacy and Medical Sciences, 2017
The aim of this paper was to examine whether moderate dyslipoproteinemia can cause an increase of hsCRP and LPO levels in Tx patients who had received immunosuppressive therapy and were without acute inflammatory diseases. Herein, the lipid levels, hsCRP,
Kimak Elzbieta, Baranowicz-Gaszczyk Iwona, Bialopiotrowicz Tomasz   +2 more
doaj   +1 more source

Lyso-DGTS Lipid Derivatives Enhance PON1 Activities and Prevent Oxidation of LDL: A Structure–Activity Relationship Study

Antioxidants, 2022
Paraoxonase 1 (PON1) plays a role in regulating reverse cholesterol transport and has antioxidative, anti-inflammatory, antiapoptotic, vasodilative, and antithrombotic activities.
Ali Khattib, Sanaa Musa, Majdi Halabi, Tony Hayek, Soliman Khatib   +4 more
doaj   +1 more source

Immune Checkpoint Inhibitor as a Fifth Component of Lipid Nanoparticles Enables Lymph Node‐Targeting and Augments mRNA Vaccine Efficacy

Advanced Science, EarlyView.
Here, a PDL1 inhibitor is employed as a fifth component to modify lipid nanoparticles (LNPs). PDL1 inhibitor‐loaded LNPs show enhanced lymph node targeting, resulting in greater lymph node expansion, immune cell infiltration, and improved mRNA vaccine efficacy. This fifth component LNP could be a novel platform for mRNA vaccines.
Minki Ha, Jaehyun Kim, Seyoung Kim, Gonna Somu Naidu, Sungchan Cho, Seok‐Beom Yong   +5 more
wiley   +1 more source

Estudo dos polimorfismos PON1-192 e PON2-311 e atividade da enzima paroxonase em pacientes diabéticos tipo 2 [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmácia, Florianópolis, 2004A paroxonase sérica humana (PON) é uma enzima localizada na HDL e está envolvida na detoxificação de ...
Catapan, Elisangela
core  

Identification and Validation of Biomarkers in Chronic Rhinosinusitis With Nasal Polyps and Study of Their Associated Mechanisms

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background Cell senescence (CS) and lipid metabolism (LM) disorders have been reported in chronic rhinosinusitis with nasal polyps (CRSwNP). However, the mechanism is still unclear. Methods Data were obtained from public databases; differential expression analysis and machine learning were performed to identify biomarkers and to understand the
Hui‐Yi Deng, Hui‐Jun Qiu, Ming‐Rui Pan, Qin‐Tai Yang   +3 more
wiley   +1 more source