Results 51 to 60 of about 16,258 (219)

Avaliação do polimorfismo genético e atividade da enzina paroxonase em pacientes hipercolesterolêmicos [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmácia, Florianópolis, 2004.A aterosclerose é a principal causa de morbidade e mortalidade no mundo ocidental e envolve ...
Favarin, Maria Elisa
core  

Main Determinants of PON1 Activity in Hemodialysis Patients [PDF]

, 2012
Cardiovascular diseases are the major cause of morbidity and mortality in hemodialysis (HD) patients. These patients present reduced paraoxonase 1 (PON1) activity that depends on genetic and non-genetic factors; however, how these factors influence PON1 ...
Costa, Elísio, Mendonca, Maria Isabel, Ribeiro, Sandra, Miranda, Vasco, Nascimento, Henrique, do Sameiro Faria, Maria, Quintanilha, Alexandre, Freitas, Isabel, Mascarenhas-Melo, Filipa, Rocha-Pereira, Petronila, Reis, Flávio, Mendonça, Denisa, Belo, Luís, Santos-Silva, Alice   +13 more
core   +1 more source

Paraoxonase-1 (PON1) induces metastatic potential and apoptosis escape via its antioxidative function in lung cancer cells

OncoTarget, 2017
Paraoxonase-1 (PON1) gene polymorphisms have been closely associated with the development of advanced cancers while PON1 secretion to the serum is linked with inhibition of oxidized high-density lipoprotein by its antioxidative function.
M. B. Aldonza, Y. Son, Hye-Jin Sung, Jung-Mo Ahn, Young-Jin Choi, Yong-In Kim, Sukki Cho, Je-Yoel Cho   +7 more
semanticscholar   +1 more source

XuanBi Mitigates Rheumatoid Arthritis via Regulation of ECM‐Receptor Interactions and IL‐17 Signaling: Insights From Integrated Proteomic and Pharmacological Analyses

Food Science &Nutrition, Volume 14, Issue 10, October 2026.
The anti‐inflammatory effect of XuanBi Herbal Formula was evaluated in arthritic rat models, in which suppression of synovial inflammation was observed. The chemical ingredients of XuanBi were detected in both the decoction and rat peripheral blood. Potential targets of the formula were then intersected with previous synovial proteomic data, through ...
Hao Zhu, Zhenfeng Pan, Ying Lu, Ping Xia, Weiming He, Jingqi Zeng, Fan Wang, Xiao Liu, Minggang Wei   +8 more
wiley   +1 more source

Transduction of PEP-1-PON1 proteins into Raw 264.7 cells.

, 2014
Cells were cultured in a 60-1-PON1 (0.1–0.3 µM) and control PON1 proteins were added to the culture media for 1 h (A), PEP-1-PON1 (0.3 µM) and control PON1 proteins were added to the culture media for 10–60 min (B), and analyzed by Western blot analysis.
Soo Young Choi (68011), Dae Won Kim (39500), Jong Hoon Park (513718), Hyun Ah Kim (68009), Eun Young Park (410793), Ora Son (513719), Jinseu Park (68010), Hoon Jae Jeong (513714), Hyo Sang Jo (513716), Won Sik Eum (513721), Mi Jin Kim (195036), Duk-Soo Kim (513717), Eun Jeong Sohn (513715), Kyu Hyung Han (513720)   +13 more
core   +1 more source

Multi‐omics–driven precision medicine

iMeta, Volume 5, Issue 5, October 2026.
Multi‐omics‐driven precision medicine (MODPM) provides a multiscale, continuously learnable framework that integrates genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiome profiles, and clinical data. Powered by artificial intelligence and foundation models, MODPM enables cross‐modal representation learning, contextual modeling ...
Huibo Li, Zhe Zhao, Yifan Zhang, Yao Ma, Gaofei Hu, Min Zeng, Zhanqun Yang, Zixuan Zhao, Xin Zhou, Wei Hu, Yuxuan Sun, Meng Su, Jun Li, Matthew Whiteman, Wei Fu, Chao Zhong, Lemin Zheng, Long Chen, Hairong Lv, Rongsheng Zhao, Yi Zhun Zhu   +20 more
wiley   +1 more source

Human Paraoxonase 1 as a Pharmacologic Agent: Limitations and Perspectives

The Scientific World Journal, 2014
Human PON1 (h-PON1) is a multifaceted enzyme and can hydrolyze (and inactivate) a wide range of substrates. The enzyme shows anti-inflammatory, antioxidative, antiatherogenic, ant-diabetic, antimicrobial, and organophosphate (OP)-detoxifying properties ...
Priyanka Bajaj, Rajan K. Tripathy, Geetika Aggarwal, Abhay H. Pande   +3 more
doaj   +1 more source

PON1 DNA methylation and neurobehavior in Mexican-American children with prenatal organophosphate exposure

Environment International, 2018
PON1 is a multifunctional enzyme involved in oxidative stress and detoxification of some organophosphate (OP) pesticides. It has been associated with nervous system diseases like Alzheimer’s disease, amyotrophic lateral sclerosis, Parkinson’s disease ...
K. Huen, Olivia Solomon, K. Kogut, B. Eskenazi, Nina T. Holland   +4 more
semanticscholar   +1 more source

Chronic, Environmentally Relevant PM2.5 Exposure Exacerbates Metabolic Dysfunction‐Associated Steatotic Liver Disease and Early‐Stage Renal Dysfunction in a Rodent Model

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 10, October 2026.
ABSTRACT While epidemiological studies link fine particulate matter (PM2.5) exposure to metabolic dysfunction‐associated steatotic liver disease (MASLD) and renal dysfunction, a translational gap exists, as most animal models utilize acute, high‐dose exposures that poorly reflect chronic, moderate‐level human scenarios.
Yi‐Siao Chen, Hugo You‐Hsien Lin, Chien‐Tzu Lin, Si‐Hua Huang, Ming‐Lun Yeh, Ming‐Lung Yu, Jin‐Ching Lee, Yao‐Chi Chung, Wei‐Ming Li, Ching‐Chia Li, Shiu‐Feng Huang, Chia‐Hung Yen   +11 more
wiley   +1 more source

Both paraoxonase-1 genotype and activity do not predict the risk of future coronary artery disease; the EPIC-Norfolk Prospective Population Study.

PLoS ONE, 2009
BackgroundParaoxonase-1 (PON1) is an antioxidant enzyme, that resides on high-density lipoprotein (HDL). PON1-activity, is heavily influenced by the PON1-Q192R polymorphism. PON1 is considered to protect against atherosclerosis, but it is unclear whether
Rakesh S Birjmohun, Menno Vergeer, Erik S G Stroes, Manjinder S Sandhu, Sally L Ricketts, Michael W Tanck, Nicholas J Wareham, J Wouter Jukema, John J P Kastelein, Kay-Tee Khaw, S Matthijs Boekholdt   +10 more
doaj   +1 more source