Results 51 to 60 of about 20,745 (266)

PON1 hypermethylation is associated with progression of renal cell carcinoma

Journal of Cellular and Molecular Medicine, 2019
In this study, our aim was to exploring the influences of DNA methylation of PON1 on cell proliferation, migration and apoptosis of renal cancer cells. The genome‐wide methylation array of renal cell carcinoma samples and adjacent tissues were obtained ...
Xin Li, Qian Yu
semanticscholar   +1 more source

Paraoxonase (PON1) Phenotype Is a Better Predictor of Vascular Disease Than Is PON1 ₁₉₂ or PON1 ₅₅ Genotype [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2000
Abstract —The paraoxonase (PON1) PON1-Q192R and PON1-L55M polymorphisms have been inconsistently associated with vascular disease. Plasma PON1 activity phenotypes vary markedly within genotypes and were, therefore, expected to add to the informativeness of genotype for predicting ...
G P, Jarvik, L S, Rozek, V H, Brophy, T S, Hatsukami, R J, Richter, G D, Schellenberg, C E, Furlong   +6 more
openaire   +2 more sources

Paraoxonase1-192 polymorphism modulates the effects of regular and acute exercise on paraoxonase1 activity

Journal of Lipid Research, 2002
Regular exercise practise is a protective factor against coronary heart disease and enhances antioxidant systems, whereas acute exercise appears to be a major source of increased oxidative stress.
Marta Tomás, Roberto Elosua, Mariano Sentí, Luis Molina, Joan Vila, Roger Anglada, Montserrat Fitó, Maria Isabel Covas, Jaume Marrugat   +8 more
doaj   +1 more source

Reconstituted high-density lipoproteins promote wound repair and blood flow recovery in response to ischemia in aged mice [PDF]

, 2016
Background: The average population age is increasing and the incidence of age-related vascular complications is rising in parallel. Impaired wound healing and disordered ischemia-mediated angiogenesis are key contributors to age-impaired vascular ...
Bursill, Christina A., Lam, Yuen Ting, Ng, Martin K. C., Ridiandries, Anisyah, Robertson, Stacy, Tan, Joanne T. M., Tsatralis, Tania, Vanags, Laura Z.   +7 more
core   +2 more sources

Paraoxonase-1 (PON1) promoter region polymorphisms, serum PON1 status and coronary heart disease

Archives of Medical Science, 2013
Serum paraoxonase-1 (PON1) retards the oxidation of low-density lipoprotein and cell membranes and is atheroprotective. Polymorphisms in the promoter region of the PON1 gene have been shown to affect serum PON1 levels and have been related to the presence of coronary heart disease (CHD) in some studies. However, contradictory results have been reported
Mackness, Bharti, Turkie, Wajdi, Mackness, Mike   +2 more
openaire   +2 more sources

Association between genetic polymorphisms and carotid atherosclerosis in patients treated with radiotherapy for nasopharyngeal carcinoma [PDF]

, 2015
published_or_final_versio
Cheuk, IW, Kwong, DLW, Wu, VWC, Ying, M, Yip, SP, Yuan, C   +5 more
core   +4 more sources

Paraoxonase (PON1 and PON3) Polymorphisms: Impact on Liver Expression and Atorvastatin-Lactone Hydrolysis [PDF]

, 2011
Atorvastatin δ-lactone, a major, pharmacologically inactive metabolite, has been associated with toxicity. In a previous study we showed that polymorphisms of UGT1A3 influence atorvastatin δ-lactone formation.
Stephan eRiedmaier, Kathrin eKlein, Stefan eWinter, Ute eHofmann, Matthias eSchwab, Matthias eSchwab, Matthias eSchwab, Ulrich M Zanger   +7 more
core   +2 more sources

Chronic, Environmentally Relevant PM2.5 Exposure Exacerbates Metabolic Dysfunction‐Associated Steatotic Liver Disease and Early‐Stage Renal Dysfunction in a Rodent Model

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT While epidemiological studies link fine particulate matter (PM2.5) exposure to metabolic dysfunction‐associated steatotic liver disease (MASLD) and renal dysfunction, a translational gap exists, as most animal models utilize acute, high‐dose exposures that poorly reflect chronic, moderate‐level human scenarios.
Yi‐Siao Chen, Hugo You‐Hsien Lin, Chien‐Tzu Lin, Si‐Hua Huang, Ming‐Lun Yeh, Ming‐Lung Yu, Jin‐Ching Lee, Yao‐Chi Chung, Wei‐Ming Li, Ching‐Chia Li, Shiu‐Feng Huang, Chia‐Hung Yen   +11 more
wiley   +1 more source

Effects of aerobic training on serum paraoxonase activity and its relationship with PON1-192 phenotypes in women

Journal of Sport and Health Science, 2016
Background: Paraoxonase 1 (PON1) is an antioxidant enzyme that protects high-density lipoprotein (HDL) and low-density lipoprotein against oxidation. Limited studies have addressed the influence of exercise on PON1 activity and its relationship with PON1
Gulbin Rudarli Nalcakan, S. Rana Varol, Faruk Turgay, Mesut Nalcakan, M. Zeki Ozkol, S. Oguz Karamizrak   +5 more
doaj   +1 more source

Lyso-DGTS Lipid Derivatives Enhance PON1 Activities and Prevent Oxidation of LDL: A Structure–Activity Relationship Study

Antioxidants, 2022
Paraoxonase 1 (PON1) plays a role in regulating reverse cholesterol transport and has antioxidative, anti-inflammatory, antiapoptotic, vasodilative, and antithrombotic activities.
Ali Khattib, Sanaa Musa, Majdi Halabi, Tony Hayek, Soliman Khatib   +4 more
doaj   +1 more source