Results 71 to 80 of about 16,258 (219)
Gene, 2015 Human PON1 is a HDL-associated lipolactonase capable of preventing LDL and cell membrane oxidation and is therefore considered to be atheroprotective. PON1 contributes to the antioxidative function of HDL and reductions in HDL-PON1 activity, prevalent in
M. Mackness, B. Mackness
semanticscholar +1 more source
Blood‐based proteomic signature of amyloidosis: identification of novel regulators of amyloid load
Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.Abstract INTRODUCTION Cerebral amyloidosis is a defining feature of Alzheimer's disease (AD), yet the molecular heterogeneity among amyloidbeta‐positive (Aβ+) individuals remains poorly defined. We aimed to map the proteomic correlates of cerebral amyloidosis and link them to clinical variability within Aβ+ individuals.
Yike Chen +18 more
wiley +1 more source
Journal of Translational Medicine, 2016 BackgroundParaoxonase 1 (PON1) gene polymorphisms and polyphenols intake have been reported independently associated to lipid profile and susceptibility to atherosclerosis and cardiovascular disease. However, the interaction between these factors remains
F. Rizzi +18 more
semanticscholar +1 more source
Food Science &Nutrition, Volume 14, Issue 6, June 2026.Aerial (leaves and flowers) and belowground (bulbs and roots) parts of Galanthus elwesii were extracted using water, 70% ethanol, and 80% methanol. Phytochemical analyses revealed organ‐ and solvent‐dependent variations in total phenolic and flavonoid contents, which were associated with differences in in vitro antioxidant activity determined by DPPH ...
Osman Ertan, Arif Ayar, Ebru Batı Ay
wiley +1 more source
Psychiatry and Clinical Neurosciences Reports, Volume 5, Issue 2, June 2026.We performed longitudinal evaluation using magnetic resonance imaging (MRI) and dopamine transporter single‐photon emission computed tomography (DAT‐SPECT) in a case of organophosphate‐induced toxic parkinsonism. Fluid‐attenuated inversion recovery (FLAIR) images showed bilateral striatal hyperintensity in the acute phase, followed by reduction of ...
Shuhei Nakao +6 more
wiley +1 more source
Levels of biochemical parameters of PON1 55 and PON1 192 carriers in the ACS patient group.
, 2015 The unpaired student’s t-test was used.Levels of biochemical parameters of PON1 55 and PON1 192 carriers in the ACS patient group.
Pamela Camponova (779670) +11 more
core +1 more source
Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.Current bladder cancer therapies can cause toxicity and bladder dysfunction. Brief intravesical‐like aripiprazole exposure reduced bladder cancer cell viability and was associated with redox stress and caspase‐3 activation, while ex vivo findings suggested preserved bladder structure and function, warranting further investigation as a potential ...
Liam A. O'Callaghan +3 more
wiley +1 more source
, 2005 Objectives The Q192R polymorphism of paraoxonase (PON1) has been shown to affect hydrolysis of organophosphorus compounds. The Q192 and R192 alloforms exhibit equivalent catalytic efficiencies of hydrolysis for diazoxon, the oxon form of the pesticide ...
TWARD A. D. +8 more
core +1 more source
The growing importance of PON1 in cardiovascular health: a review
, 2012 The wide acceptance of the oxidation theory of atherogenesis has prompted attention to antioxidant mechanisms, particularly the prevention of lipid oxidation by high-density lipoprotein-associated proteins like paraoxonase 1 (PON1) enzyme.
Blackhurst, Diane M. +4 more
core +2 more sources
Induction of paraoxonase 1 and apolipoprotein A-I gene expression by aspirin*
Journal of Lipid Research, 2008 Low-dose aspirin therapy has become a standard in the treatment of cardiovascular diseases. Aspirin has been shown to inhibit atherosclerosis in mouse models.
Priscilla Jaichander +3 more
doaj +1 more source