Results 61 to 70 of about 6,713 (180)

The association between PON1 gene polymorphisms (Q192R and L55M) and nephrotic syndrome in Iraqi children

Baghdad Journal of Biochemistry and Applied Biological Sciences, 2021
Background: The role of paraoxonase 1 enzyme (PON1) and its single nucleotide polymorphisms (SNPs) in children with nephrotic syndrome (NS) has been reported previously in different ethnic and racial groups with divergent results.
Raghad Ali, Rayah Baban, Shatha Ali
doaj  

Rare coding variation in paraoxonase-1 is associated with ischemic stroke in the NHLBI Exome Sequencing Project[S]

Journal of Lipid Research, 2014
HDL-associated paraoxonase-1 (PON1) is an enzyme whose activity is associated with cerebrovascular disease. Common PON1 genetic variants have not been consistently associated with cerebrovascular disease.
Daniel Seung Kim, David R. Crosslin, Paul L. Auer, Stephanie M. Suzuki, Judit Marsillach, Amber A. Burt, Adam S. Gordon, James F. Meschia, Mike A. Nalls, Bradford B. Worrall, W.T. Longstreth, Jr., Rebecca F. Gottesman, Clement E. Furlong, Ulrike Peters, Stephen S. Rich, Deborah A. Nickerson, Gail P. Jarvik   +16 more
doaj   +1 more source

Intrinsic Factors Influencing Simvastatin and Simvastatin Acid Pharmacokinetics: Age‐Related Studies in Thai Adults and Cross‐Population Comparisons

Clinical and Translational Science, Volume 19, Issue 2, February 2026.
ABSTRACT Intrinsic factors such as age and ethnicity influence statin pharmacokinetics (PK) and may increase the risk of muscle‐related adverse events. This study investigated the effect of age on the PK of simvastatin (SV) and its active metabolite, simvastatin acid (SVA), in healthy Thai subjects using an LC–MS/MS assay while accounting for key ...
Thanate Srimatimanon, Udomsak Udomnilobol, Pajaree Chariyavilaskul, Sarawut Siwamogsatham, Kearkiat Praditpornsilpa, Yongkasem Vorasettakarnkij, Aisawan Petchlorlian, Natchaya Vanwong, Jittima Piriyapongsa, Pavita Tipsombatboon, Varalee Yodsurang, Thomayant Prueksaritanont   +11 more
wiley   +1 more source

Investigation of the effects of Terminalia chebula seed hydroalcoholic extract on Paraoxonase1 enzyme activity in rats [PDF]

Journal of Shahrekord University of Medical Sciences
Background and aims: Paraoxonase 1 (PON1) is related to high-density lipoprotein (HDL) in serum and protects against low-density lipoprotein (LDL) oxidation. This study aimed to investigate the effects of Terminalia chebula on PON1 in hyperlipidemic rats
Parastoo Taghipour, Sahar Rostamian, Gholamreza Mobini, Keyhan Ghatreh-Samani, Mahmoud Rafieian-Kopaei, Javad Saffari-Chaleshtori   +5 more
doaj   +1 more source

Paraoxonase-1 (PON1) promoter region polymorphisms, serum PON1 status and coronary heart disease

Archives of Medical Science, 2013
Serum paraoxonase-1 (PON1) retards the oxidation of low-density lipoprotein and cell membranes and is atheroprotective. Polymorphisms in the promoter region of the PON1 gene have been shown to affect serum PON1 levels and have been related to the presence of coronary heart disease (CHD) in some studies. However, contradictory results have been reported
Mackness, Bharti, Turkie, Wajdi, Mackness, Mike   +2 more
openaire   +2 more sources

Development of an immunoblot assay with infrared fluorescence to quantify paraoxonase 1 in serum and plasma

Journal of Lipid Research, 2008
Paraoxonase 1 (PON1) requires calcium for activity and is inactivated in the presence of EDTA. Because of this, studies to date have used serum or heparinized plasma for both activity and mass assays of PON1.
Philip W. Connelly, Graham F. Maguire, Clive M. Picardo, John F. Teiber, Dragomir Draganov   +4 more
doaj   +1 more source

HDL subfraction distribution of paraoxonase-1 and its relevance to enzyme activity and resistance to oxidative stress

Journal of Lipid Research, 2008
The subfraction distribution of HDL-associated peptides has implications for their functions and the impact of pathological modifications to lipoprotein metabolism on these functions.
Xenia Moren, Sara Deakin, Ming-Lin Liu, Marja-Riitta Taskinen, Richard W. James   +4 more
doaj   +1 more source

Frontocingulate Dysfunction Is Associated with Depression and Decreased Serum PON1 in Methamphetamine-Dependent Patients

Neuropsychiatric Disease and Treatment, 2020
Nooshin Ghavidel,1 Fariba Khodagholi,1 Abolhassan Ahmadiani,1 Reza Khosrowabadi,2 Sareh Asadi,3 Jamal Shams4 1Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2Institute for Cognitive and Brain Sciences, Shahid ...
Ghavidel N, Khodagholi F, Ahmadiani A, Khosrowabadi R, Asadi S, Shams J   +5 more
doaj  

Paraoxonase 1 serum activity in women: the effects of menopause, the C(-107)T polymorphism and food intake

Archives of Endocrinology and Metabolism, 2019
Objective The aims of this study were to investigate changes in serum paraoxonase 1 (PON1) activity in women at the pre and postmenopausal stages and its association with the PON1 C(-107)T polymorphism and food intake profile.
Mauren Castro Ritta, Aline Marques Baldez, Isabel Oliveira de Oliveira, Driele Neske Garcia, Paola Spiering Souza, Kelvin Ruan da Silva Andrade, Sandra Costa Valle, Simone Pieniz, Carlos Castilho Barros, Michal M. Masternak, Augusto Schneider   +10 more
doaj   +1 more source

Susceptibility of PON1/PON2 Genetic Variations to Ischemic Stroke Risk in a Chinese Han Population

Pharmacogenomics and Personalized Medicine, 2020
Yuqin Pan,1,* Bangshun He,1,* Huiling Sun,1 Tao Xu,1 Bei Pan,1 Shukui Wang,1 Yanping Mei2 1General Clinical Research Center, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu Province, 210006, People’s Republic of China ...
Pan Y, He B, Sun H, Xu T, Pan B, Wang S, Mei Y   +6 more
doaj