Results 81 to 90 of about 20,745 (266)

Association of the polycystic ovary syndrome with genomic variants related to insulin resistance, type 2 diabetes mellitus, and obesity [PDF]

, 1982
7 pages, 2 tables.-- Results from this work were presented at the 85th Annual Meeting of The Endocrine Society, Philadelphia, PA, June 2003.We have evaluated the possible association of polycystic ovary syndrome (PCOS) with 15 genomic variants ...
San Millán, José L., Cortón, Marta, Villuendas, Gemma, Sancho, José, Peral, Belén, Escobar-Morreale, Héctor F.   +5 more
core   +1 more source

Statins in Breast Cancer Therapy: Mechanistic Insights and Emerging Evidence

Cancer Innovation, Volume 5, Issue 1, February 2026.
Statins, particularly simvastatin, demonstrate potential as adjuvant agents in breast cancer treatment by disrupting tumour cell signalling and survival pathways. This review highlights emerging evidence supporting their repurposing for improved outcomes, especially in aggressive breast cancer subtypes.
Rohina Alim, H. M. Kasuni Akalanka
wiley   +1 more source

High-density lipopoprotein antioxidant capacity, subpopulation distribution and paraoxonase-1 activity in patients with systemic lupus erythematosus [PDF]

, 2016
BACKGROUND: The causes of increased cardiovascular risk in systemic lupus erythematosus (SLE) are not understood thoroughly, although presence of traditional cardiovascular risk factors and disease-specific agents were also proposed.
György Paragh, Hajnalka Lőrincz, Ildikó Seres, Krisztina Gaál, Mariann Harangi, Péter Fülöp, Tünde Tarr, Viktor Borbás   +7 more
core   +1 more source

Digital Biomarkers for Precision Early Detection of Lung Cancer: Integrating AI‐Driven Multi‐Omics Into Clinical Pathways

Cancer Medicine, Volume 15, Issue 2, February 2026.
ABSTRACT Background Lung cancer remains the leading cause of cancer‐related mortality worldwide, highlighting the urgent need for earlier detection within real‐world screening and patient management pathways. Recent advances in multi‐omics technologies have created new opportunities for identifying biomarkers associated with early‐stage lung cancer ...
Fan Bu, Zhi‐Qiang Ling
wiley   +1 more source

Interrelationship of serum paraoxonase activity and paraoxonase genetic variants on atherosclerosis risk [PDF]

, 2000
La paraoxonasa (PON1) és una esterasa calciodepenent estretament associada a les lipoproteïnes d'alta densitat (HDL) que contenen apolipoproteïna AI, i s'ha descrit que dóna capacitat antioxidant a les HDL, amb la qual cosa disminueix l'acumulació dels ...
Elosua, Roberto, Marrugat, Jaume, Sentí, Mariano, Tomàs, Marta   +3 more
core   +1 more source

Intrinsic Factors Influencing Simvastatin and Simvastatin Acid Pharmacokinetics: Age‐Related Studies in Thai Adults and Cross‐Population Comparisons

Clinical and Translational Science, Volume 19, Issue 2, February 2026.
ABSTRACT Intrinsic factors such as age and ethnicity influence statin pharmacokinetics (PK) and may increase the risk of muscle‐related adverse events. This study investigated the effect of age on the PK of simvastatin (SV) and its active metabolite, simvastatin acid (SVA), in healthy Thai subjects using an LC–MS/MS assay while accounting for key ...
Thanate Srimatimanon, Udomsak Udomnilobol, Pajaree Chariyavilaskul, Sarawut Siwamogsatham, Kearkiat Praditpornsilpa, Yongkasem Vorasettakarnkij, Aisawan Petchlorlian, Natchaya Vanwong, Jittima Piriyapongsa, Pavita Tipsombatboon, Varalee Yodsurang, Thomayant Prueksaritanont   +11 more
wiley   +1 more source

Interaction between polyphenols intake and PON1 gene variants on markers of cardiovascular disease: a nutrigenetic observational study

Journal of Translational Medicine, 2016
BackgroundParaoxonase 1 (PON1) gene polymorphisms and polyphenols intake have been reported independently associated to lipid profile and susceptibility to atherosclerosis and cardiovascular disease. However, the interaction between these factors remains
F. Rizzi, C. Conti, E. Dogliotti, A. Terranegra, E. Salvi, D. Braga, F. Ricca, S. Lupoli, A. Mingione, F. Pivari, Caterina Brasacchio, M. Barcella, Martina Chittani, F. D’Avila, M. Turiel, M. Lazzaroni, L. Soldati, D. Cusi, C. Barlassina   +18 more
semanticscholar   +1 more source

Adipocitokinek hatása a HDL mennyiségére és funkciójára az atherosclerosis szempontjából veszélyeztetett betegcsoportokban = The effect of adipocitokines on HDL level and function in atherosclerotic patients [PDF]

, 2010
Az adipocitokinek és a statin kezelés hatását tanulmányoztuk a HDL funkcióira érelmeszesedés szempontjából fokozott kockázatú betegeken. Elhízott gyermekekben és felnőttekben csökkent antioxidáns hatású paraoxonáz (PON1) aktivitást, emelkedett ...
Harangi, Mariann, Paragh, György, Seres, Ildikó   +2 more
core  

Bidirectional Communication Between Astrocytes and Neurons via Extracellular Vesicles: A Multi‐Omics Approach

Journal of Neurochemistry, Volume 170, Issue 2, February 2026.
Schematic diagram illustrating the communication between mouse hippocampal astrocytes and neurons through extracellular vesicles (EVs). The illustration highlights unique proteins secreted by each cell type within EVs, with vesicle size proportional to the concentration of secreted proteins.
Daria Hajka, Paulina Żebrowska‐Różańska, Katarzyna Romańczuk, Jacek R. Wiśniewski, Łukasz Łaczmański, Norbert Łodej, Krzysztof J. Pawlik, Dariusz Rakus, Agnieszka Gizak   +8 more
wiley   +1 more source

Biomarkers in patients with clinical signs of mild cognitive impairment or mild Alzheimer's disease but without amyloid deposits on positron emission tomography: Results from Bio‐Hermes Study participants

Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.
Abstract INTRODUCTION Alzheimer's disease (AD) study participants may present with cognitive impairment who do not have brain amyloid deposits (Aβ−). Identifying predictive biomarkers for non‐amyloid‐related CI may provide better screening tests for trials seeking only CI Aβ+ participants and new therapy targets.
Richard C. Mohs, Douglas W. Beauregard, Lynne Hughes, Cyndy B. Cordell, Allan I. Levey, Saima Rathore, Nicholas T. Seyfried, Erik C. B. Johnson, Jessie Nicodemus‐Johnson, Joshua Christensen, Robin Wolz, John Dwyer   +11 more
wiley   +1 more source