Results 91 to 100 of about 16,258 (219)

Potential Effects of Aspirin on Transcription Factors Related to the Inflammation in Atherosclerosis: A Systematic Review

Health Science Reports, Volume 9, Issue 4, April 2026.
ABSTRACT Background and Aims Atherosclerosis (AS), a major cause of cardiovascular mortality, involves chronic inflammation mediated by transcription factors such as NF‐κB, PPARs, and AP‐2α. Beyond its antiplatelet role, aspirin exerts anti‐inflammatory effects that may influence these molecular pathways.
Mojtaba Aghaei, Reyhane Khademi, Seyed Sobhan Bahreiny, Habib Haybar, Ekhlas Torfi, Shirin Azizidoost, Najmaldin Saki   +6 more
wiley   +1 more source

Gene-environemnt interactions: paraoxonase (PON1) and sensitivity to organophosphate toxicity

, 2006
Paraoxonase (PON1) is a liver and plasma enzyme that hydrolyzes the active metabolites of several organophosphorus insecticides, PON1 displays several polymorphisms that influence both its level of expression and its catalytic activity, thereby ...
FURLONG CE, COLE TB, COSTA, Lucio Guido
core   +1 more source

The Frequency of PON1 L55M Polymorphism and Measurement of Oxidative Stress Parameters (Superoxide Dismutase, Catalase, Thiol, and Carbonyl) in Neonates with G6PD Deficiency Compared to the Control Group

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2019
Introduction: Glucose-6-phosphate dehydrogenase deficiency is the most common enzyme disorder. This enzyme involved in maintaining the balance of active oxygen species and its defect causes oxidative damage. PON1 is an HDL-based glycosylated protein that
Vahide Jamshidi, Vahid Pourshafiei, Mahmoud Vakili, Ali Moradi   +3 more
doaj  

Investigation of the effects of Terminalia chebula seed hydroalcoholic extract on Paraoxonase1 enzyme activity in rats [PDF]

Journal of Shahrekord University of Medical Sciences
Background and aims: Paraoxonase 1 (PON1) is related to high-density lipoprotein (HDL) in serum and protects against low-density lipoprotein (LDL) oxidation. This study aimed to investigate the effects of Terminalia chebula on PON1 in hyperlipidemic rats
Parastoo Taghipour, Sahar Rostamian, Gholamreza Mobini, Keyhan Ghatreh-Samani, Mahmoud Rafieian-Kopaei, Javad Saffari-Chaleshtori   +5 more
doaj   +1 more source

Associations of maternal organophosphate pesticide exposure and PON1 activity with birth outcomes in SAWASDEE birth cohort, Thailand

Environmental Research, 2015
Prenatal organophosphate (OP) pesticide exposure has been reported to be associated with adverse birth outcomes and neurodevelopment. However, the mechanisms of toxicity of OP pesticides on human fetal development have not yet been elucidated.
W. Naksen, T. Prapamontol, A. Mangklabruks, S. Chantara, P. Thavornyutikarn, Niphan Srinual, Parinya Panuwet, P. Ryan, A. Riederer, D. Barr   +9 more
semanticscholar   +1 more source

Defective high‐density lipoprotein lipoprotection in type 2 diabetes during acute myocardial infarction is rescued by apolipoprotein M/sphingosine‐1‐phosphate loading

Diabetes, Obesity and Metabolism, Volume 28, Issue 3, Page 2175-2182, March 2026.
Abstract Aims Mortality of patients with type 2 diabetes (T2D) after acute myocardial infarction (AMI) is tremendous and massively increased compared to non‐T2D individuals. The reasons are unclear. High‐density lipoprotein (HDL) conducts lipoprotection during AMI, leading to improved outcomes.
Jens Vogt, Marcel Benkhoff, Nathalie H. Schröder, Hao Hu, Lisa Dannenberg, Petra Keul, Theresia Sarabhai, Kálmán Benedikt Bódis, Tobias Zeus, Philipp Wollnitzke, Malte Kelm, Amin Polzin, Bodo Levkau   +12 more
wiley   +1 more source

Functional genomics of paraoxonase (PON1) polymorphisms: effects on pesticide sensitivity, cardiovascular disease and drug metabolism.

, 2003
This review focuses on the functional genomics of the human paraoxonase (PON1) polymorphisms. Levels and genetic variability of the PON1 position 192 isoforms (Gln/Arg) influence sensitivity to specific insecticides or nerve agents and risk for ...
JARVIK G. P., COLE T. B., COSTA, Lucio Guido, FURLONG C. E.   +3 more
core   +1 more source

The 192R/Q polymorphs of serum paraoxonase PON1 differ in HDL binding, lipolactonase stimulation, and cholesterol effluxs⃞

Journal of Lipid Research, 2006
Serum paraoxonase (PON1) is a HDL-associated enzyme exhibiting potentially antiatherogenic properties. Here, we examined the common PON1-192R/Q human polymorphism. Despite numerous studies, the effect of this polymorphism on the antiatherogenic potential
Leonid Gaidukov, Mira Rosenblat, Michael Aviram, Dan S. Tawfik   +3 more
doaj   +1 more source

Comparing Atherogenic Ratios Using Paraoxonase 1 and HDL-C in Diagnosis of Severity of Coronary Artery Disease in Type 2 Diabetes Patients with Nephropathy [PDF]

Journal of Mazandaran University of Medical Sciences, 2023
Background and purpose: Recent studies suggest that HDL-C may not serve as a useful biomarker in the diagnosis of coronary artery disease (CAD). The present study aimed to improve the prediction of CAD in type 2 diabetes (T2D) patients with nephropathy ...
Abdolkarim Mahrooz, Omeh Farveh Khosravi-Asrami, Ahad Alizadeh, Mani Nosrati   +3 more
doaj  

Paraoxonase/arylesterase ratio, PON1 192Q/R polymorphism and PON1 status are associated with increased risk of ischernic stroke

, 2008
Objectives: In recent years, importance of enzyme activity measurements, in addition to genotyping, in epidemiological studies relating paraoxonase 1 (PON1) and vascular disease was emphasized.
ADALI, ORHAN, Sanisoglu, Yavuz, Demirkaya, Seref, Demirdogen, Birsen Can, Vural, Okay, Turkanoglu, Aysun, Arinc, Emel, Bek, Semai, Adalı, Orhan, Can Demirdöǧen, Birsen   +9 more
core   +1 more source