Results 31 to 40 of about 16,258 (219)

Marked Long-Term Improvement in Lung Function in Melanoma Differentiation-Associated Protein 5 Antibody-Positive Dermatomyositis Patients: Experience of a Single-Center Longitudinal Cohort in North America. [PDF]

Arthritis Care Res (Hoboken)
Objective The objective of this study was to describe the longitudinal disease course and pulmonary outcomes of North American patients with melanoma differentiation–associated protein 5 (MDA5) antibody–associated dermatomyositis (DM). Methods Thirty patients with MDA5 antibody–associated DM were identified in a single‐center longitudinal cohort of 352
Cheah JX, Bae SS, De Leon T, Lee Y, Guo R, Elashoff D, Wang J, Shahbazian A, Charles-Schoeman C.   +8 more
europepmc   +2 more sources

Study of the diagnostic utility of paraoxonase enzyme in serum and bronchoalveolar lavage in patients with lung cancer

Egyptian Journal of Chest Disease and Tuberculosis, 2022
Backgrounds PON1 plays a main role in preventing oxidative stress, and also it is important in removal of carcinogenic lipid-soluble radicals caused by lipid peroxidation. Bronchoalveolar lavage (BAL) is a sampling technique used in flexible bronchoscopy
Samar S Elseady, Ragia S Sharshar, Amira Y Abdelnaby, Ali M AbdElla   +3 more
doaj   +1 more source

Lowered PON1 activities are strongly associated with depression and bipolar disorder, recurrence of (hypo)mania and depression, increased disability and lowered quality of life

World Journal of Biological Psychiatry, 2019
Objectives: Mood disorders (MDs) frequently co-exist with cardiovascular disease (CVD) and immune-inflammatory and oxidative stress are important shared pathophysiological pathways.
E. Moreira, D. Correia, K. Bonifácio, Juliana Brum de Moraes, Fernanda Liboni Cavicchioli, Caroline Sampaio Nunes, S. O. Nunes, H. O. Vargas, D. Barbosa, M. Maes   +9 more
semanticscholar   +1 more source

PON1 (Paraoxonase 1) Q192R gene polymorphism in ischemic stroke among North Indian population

Annals of Indian Academy of Neurology, 2022
Background: PON1 is an High Density Lipoprotein (HDL)-associated esterase. Two common polymorphisms in the PON1 gene, Q192R and L55M substitutions, determine the inter-individual variation in PON1 activity. The association of these polymorphisms with the
Ankit Gupta, Alvee Saluja, Kallur Nava Saraswathy, Longkumer Imnameren, Suniti Yadav, Rajinder K Dhamija   +5 more
doaj   +1 more source

Paraoxonase-1 status in patients with hereditary hemochromatosis

Journal of Lipid Research, 2013
Hereditary hemochromatosis (HH) is characterized by accumulation of iron, oxidative stress, inflammation, and fibrogenesis in liver tissue. In this setting, research on the protection afforded by intracellular antioxidants is of clinical relevance ...
Nicola Martinelli, Anabel García-Heredia, Helena Roca, Núria Aranda, Victoria Arija, Bharti Mackness, Michael Mackness, Fabiana Busti, Gerard Aragonès, Juan Pedro-Botet, Federica Pedica, Ivana Cataldo, Judit Marsillach, Jorge Joven, Domenico Girelli, Jordi Camps   +15 more
doaj   +1 more source

Both CYP2C19 and PON1 Q192R Genotypes Influence Platelet Response to Clopidogrel by Thrombelastography in Patients with Acute Coronary Syndrome

Cardiovascular Therapeutics, 2019
Objective The objective of this study is to explore the relationships of the effects of CYP2C19 and PON1 Q192R polymorphism on the activity of clopidogrel and the risk of high platelet responsiveness (HPR) by thrombelastography in patients with acute ...
Wenxing Peng, Xiu-Jin Shi, Xiaoyu Xu, Yang Lin   +3 more
semanticscholar   +1 more source

PON1 concentration and high-density lipoprotein characteristics as cardiovascular biomarkers

Archives of medical sciences. Atherosclerotic diseases, 2019
Introduction Serum paraoxonase 1 (PON1) is now known to be related to cardiovascular diseases (CVD). The aim of this study was to determine the relationship between PON1 concentration and high-density lipoprotein (HDL) subclasses in patients with proven ...
Fátima E. Murillo González, N. Ponce-Ruíz, A. Rojas-García, Y. Y. Bernal-Hernández, M. Mackness, J. Ponce-Gallegos, G. Cardoso-Saldaña, E. Jorge-Galarza, M. Torres-Tamayo, I. Medina-Díaz   +9 more
semanticscholar   +1 more source

The Association between PON1 (Q192R and L55M) Gene Polymorphisms and Risk of Cancer: A Meta-Analysis Based on 43 Studies

BioMed Research International, 2019
Q192R and L55M polymorphism were considered to be associated with the development of multiple cancers. Nevertheless, the results of these researches were inconclusive and controversial. Therefore, we conducted a meta-analysis of all eligible case-control
Xiao-Lan Pan, Lei Huang, Meiqin Li, Dan Mo, Yihua Liang, Zhi-Ming Liu, Zhaodong Huang, Ling-Sha Huang, Jinfeng Liu, Bo Zhu   +9 more
semanticscholar   +1 more source

Paraoxonase1-192 polymorphism modulates the effects of regular and acute exercise on paraoxonase1 activity

Journal of Lipid Research, 2002
Regular exercise practise is a protective factor against coronary heart disease and enhances antioxidant systems, whereas acute exercise appears to be a major source of increased oxidative stress.
Marta Tomás, Roberto Elosua, Mariano Sentí, Luis Molina, Joan Vila, Roger Anglada, Montserrat Fitó, Maria Isabel Covas, Jaume Marrugat   +8 more
doaj   +1 more source

Paraoxonase-1 Serum Concentration and PON1 Gene Polymorphisms: Relationship with Non-Alcoholic Fatty Liver Disease

Journal of Clinical Medicine, 2019
Background: Non-alcoholic fatty liver disease (NAFLD) is an important cause of chronic liver diseases around the world. Paraoxonase-1 (PON1) is an enzyme produced by the liver with an important antioxidant role. The aim of this study was to evaluate PON1
M. Milaciu, Ș. Vesa, I. Bocșan, L. Ciumărnean, D. Sâmpelean, V. Negrean, R. Pop, D. Matei, Sergiu Pasca, A. Rãchişan, A. Buzoianu, M. Acalovschi   +11 more
semanticscholar   +1 more source