Results 21 to 30 of about 16,258 (219)

Genetic Attenuation of Paraoxonase 1 Activity Induces Proatherogenic Changes in Plasma Proteomes of Mice and Humans

Antioxidants, 2020
High-density lipoprotein (HDL), in addition to promoting reverse cholesterol transport, possesses anti-inflammatory, antioxidative, and antithrombotic activities.
Marta Sikora, Ewa Bretes, Joanna Perła-Kaján, Izabela Lewandowska, Łukasz Marczak, Hieronim Jakubowski   +5 more
doaj   +1 more source

Paraoxonase 1 gene polymorphisms in lipid oxidation and atherosclerosis development

Frontiers in Genetics, 2022
Paraoxonase 1 (PON1) is calcium-dependent aryldialkylphosphatase, thought to possess; anti-oxidant, anti-adhesion, anti-inflammatory, anti-thrombosis and anti-apoptosis effects, as well as lipid-modifying properties.
Marija Vavlukis, Marija Vavlukis, Ana Vavlukis, Katerina Krsteva, Sonja Topuzovska   +4 more
doaj   +1 more source

A Multi-Omics Analysis of PON1 Lactonase Activity in Relation to Human Health and Disease

Omics, 2020
Paraoxonase 1 (PON1) enzyme has antioxidative properties and is present in mammalian blood and several other body fluids. In blood, PON1 is usually integrated into the high-density lipoprotein (HDL) cholesterol.
Boštjan Petrič, T. Kunej, A. Bavec
semanticscholar   +1 more source

TagSNP analyses of the PON gene cluster: effects on PON1 activity, LDL oxidative susceptibility, and vascular disease

Journal of Lipid Research, 2006
Paraoxonase 1 (PON1) activity is consistently predictive of vascular disease, although the genotype at four functional PON1 polymorphisms is not. To address this inconsistency, we investigated the role of all common PON1 genetic variability, as measured ...
Christopher S. Carlson, Patrick J. Heagerty, Thomas S. Hatsukami, Rebecca J. Richter, Jane Ranchalis, Julieann Lewis, Tamara J. Bacus, Laura A. McKinstry, Gerard D. Schellenberg, Mark Rieder, Deborah Nickerson, Clement E. Furlong, Alan Chait, Gail P. Jarvik   +13 more
doaj   +1 more source

Antioxidant status in hypertensive disorders of pregnancy

Hypertension in Pregnancy, 2022
Objective Pregnancy can be associated with maternal hypertension leading to possible complications in pregnancy outcome. Antioxidant status may be proned to changes during pregnancy with hypertension.
Jasmina Ivanišević, Daniela Ardalić, Gorica Banjac, Jelena Janać, Petar Cabunac, Jelena Vekić, Aleksandra Zeljković, Vesna Spasojević- Kalimanovska, Nataša Karadžov Orlić, Vesna Mandić Marković, Željko Miković, Aleksandra Stefanović   +11 more
doaj   +1 more source

The correlation of paraoxonase (PON1) activity with lipid and lipoprotein levels differs with vascular disease status

Journal of Lipid Research, 2005
Paraoxonase (PON1) is an HDL-associated enzyme. Low PON1 activity predicts vascular disease status and is a more reliable predictor of vascular disease than are functional PON1 genotypes.
Laura S. Rozek, Thomas S. Hatsukami, Rebecca J. Richter, Jane Ranchalis, Karen Nakayama, Laura A. McKinstry, David A. Gortner, Edward Boyko, Gerard D. Schellenberg, Clement E. Furlong, Gail P. Jarvik   +10 more
doaj   +1 more source

Lactonase Activity, Status, and Genetic Variations of Paraoxonase 1 in Women with Gestational Diabetes Mellitus

Journal of Diabetes Research, 2020
Background. Paraoxonase 1 (PON1) is a calcium-dependent multifunctional enzyme that binds to high-density lipoproteins. The physiological function of PON1 is related to its lactonase activity.
Mi Zhou, Xing-Hui Liu, Qing-Qing Liu, Meng Chen, Huai Bai, Lin-Bo Guan, Ping Fan   +6 more
doaj   +1 more source

The Increase in Paraoxonase 1 Is Associated With Decrease in Left Ventricular Volume in Kidney Transplant Recipients

Frontiers in Cardiovascular Medicine, 2021
Background: Patients on dialysis have impaired cardiac function, in part due to increased fluid volume and ventricular stress. Restored kidney function through transplantation reduces left ventricular volume in both systole and diastole.
Philip W. Connelly, Philip W. Connelly, Philip W. Connelly, Andrew T. Yan, Michelle M. Nash, Rachel M. Wald, Charmaine Lok, Lakshman Gunaratnam, Anish Kirpalani, G. V. Ramesh Prasad   +9 more
doaj   +1 more source

Developmental and social deficits and enhanced sensitivity to prenatal chlorpyrifos in PON1-/- mouse pups and adults.

PLoS ONE, 2020
The levels and activity of the enzyme paraoxonase 1 affect the vulnerability to the teratogenic effects of organophosphate pesticides. Mutant mice lacking the gene for paraoxonase1 (PON1-/-) are more susceptible to the toxic effects of chlorpyrifos, and ...
Ora Kofman, Anat Lan, Eynav Raykin, Ksenija Zega, Claude Brodski   +4 more
doaj   +1 more source

Resveratrol exhibits an effect on attenuating retina inflammatory condition and damage of diabetic retinopathy via PON1

Experimental Eye Research, 2019
Diabetic retinopathy (DR), an obstacle of the visual microvascular system, is a serious complication of diabetic patients. Paraoxonase 1 (PON1) has been extensively evaluated as a genetic candidate for diabetic microvascular complications, and PON1 is ...
Yuhua Chen, Jiao Meng, Hua Li, Hong Wei, Fang-Fang Bi, Shi Liu, K. Tang, Hai-Yu Guo, Wei Liu   +8 more
semanticscholar   +1 more source