Results 21 to 30 of about 6,713 (180)

The correlation of paraoxonase (PON1) activity with lipid and lipoprotein levels differs with vascular disease status

Journal of Lipid Research, 2005
Paraoxonase (PON1) is an HDL-associated enzyme. Low PON1 activity predicts vascular disease status and is a more reliable predictor of vascular disease than are functional PON1 genotypes.
Laura S. Rozek, Thomas S. Hatsukami, Rebecca J. Richter, Jane Ranchalis, Karen Nakayama, Laura A. McKinstry, David A. Gortner, Edward Boyko, Gerard D. Schellenberg, Clement E. Furlong, Gail P. Jarvik   +10 more
doaj   +1 more source

Lactonase Activity, Status, and Genetic Variations of Paraoxonase 1 in Women with Gestational Diabetes Mellitus

Journal of Diabetes Research, 2020
Background. Paraoxonase 1 (PON1) is a calcium-dependent multifunctional enzyme that binds to high-density lipoproteins. The physiological function of PON1 is related to its lactonase activity.
Mi Zhou, Xing-Hui Liu, Qing-Qing Liu, Meng Chen, Huai Bai, Lin-Bo Guan, Ping Fan   +6 more
doaj   +1 more source

The Increase in Paraoxonase 1 Is Associated With Decrease in Left Ventricular Volume in Kidney Transplant Recipients

Frontiers in Cardiovascular Medicine, 2021
Background: Patients on dialysis have impaired cardiac function, in part due to increased fluid volume and ventricular stress. Restored kidney function through transplantation reduces left ventricular volume in both systole and diastole.
Philip W. Connelly, Philip W. Connelly, Philip W. Connelly, Andrew T. Yan, Michelle M. Nash, Rachel M. Wald, Charmaine Lok, Lakshman Gunaratnam, Anish Kirpalani, G. V. Ramesh Prasad   +9 more
doaj   +1 more source

Developmental and social deficits and enhanced sensitivity to prenatal chlorpyrifos in PON1-/- mouse pups and adults.

PLoS ONE, 2020
The levels and activity of the enzyme paraoxonase 1 affect the vulnerability to the teratogenic effects of organophosphate pesticides. Mutant mice lacking the gene for paraoxonase1 (PON1-/-) are more susceptible to the toxic effects of chlorpyrifos, and ...
Ora Kofman, Anat Lan, Eynav Raykin, Ksenija Zega, Claude Brodski   +4 more
doaj   +1 more source

Paraoxonase (PON1) Phenotype Is a Better Predictor of Vascular Disease Than Is PON1 ₁₉₂ or PON1 ₅₅ Genotype [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2000
Abstract —The paraoxonase (PON1) PON1-Q192R and PON1-L55M polymorphisms have been inconsistently associated with vascular disease. Plasma PON1 activity phenotypes vary markedly within genotypes and were, therefore, expected to add to the informativeness of genotype for predicting ...
G P, Jarvik, L S, Rozek, V H, Brophy, T S, Hatsukami, R J, Richter, G D, Schellenberg, C E, Furlong   +6 more
openaire   +2 more sources

Study of the diagnostic utility of paraoxonase enzyme in serum and bronchoalveolar lavage in patients with lung cancer

Egyptian Journal of Chest Disease and Tuberculosis, 2022
Backgrounds PON1 plays a main role in preventing oxidative stress, and also it is important in removal of carcinogenic lipid-soluble radicals caused by lipid peroxidation. Bronchoalveolar lavage (BAL) is a sampling technique used in flexible bronchoscopy
Samar S Elseady, Ragia S Sharshar, Amira Y Abdelnaby, Ali M AbdElla   +3 more
doaj   +1 more source

Paraoxonase-1 status in patients with hereditary hemochromatosis

Journal of Lipid Research, 2013
Hereditary hemochromatosis (HH) is characterized by accumulation of iron, oxidative stress, inflammation, and fibrogenesis in liver tissue. In this setting, research on the protection afforded by intracellular antioxidants is of clinical relevance ...
Nicola Martinelli, Anabel García-Heredia, Helena Roca, Núria Aranda, Victoria Arija, Bharti Mackness, Michael Mackness, Fabiana Busti, Gerard Aragonès, Juan Pedro-Botet, Federica Pedica, Ivana Cataldo, Judit Marsillach, Jorge Joven, Domenico Girelli, Jordi Camps   +15 more
doaj   +1 more source

PON1 (Paraoxonase 1) Q192R gene polymorphism in ischemic stroke among North Indian population

Annals of Indian Academy of Neurology, 2022
Background: PON1 is an High Density Lipoprotein (HDL)-associated esterase. Two common polymorphisms in the PON1 gene, Q192R and L55M substitutions, determine the inter-individual variation in PON1 activity. The association of these polymorphisms with the
Ankit Gupta, Alvee Saluja, Kallur Nava Saraswathy, Longkumer Imnameren, Suniti Yadav, Rajinder K Dhamija   +5 more
doaj   +1 more source

PON1 multitasks to protect health [PDF]

Proceedings of the National Academy of Sciences, 2008
The enzyme paraoxonase 1 (PON1) is an excellent example of a multitasking protein, displaying at least two very important functions: hydrolysis of organophosphorus (OP) anticholinesterases and prevention of oxidation of low density lipoproteins (LDLs) and high density lipoproteins (HDLs).
openaire   +2 more sources

Lyso-DGTS Lipid Derivatives Enhance PON1 Activities and Prevent Oxidation of LDL: A Structure–Activity Relationship Study

Antioxidants, 2022
Paraoxonase 1 (PON1) plays a role in regulating reverse cholesterol transport and has antioxidative, anti-inflammatory, antiapoptotic, vasodilative, and antithrombotic activities.
Ali Khattib, Sanaa Musa, Majdi Halabi, Tony Hayek, Soliman Khatib   +4 more
doaj   +1 more source