PON2 Deficiency Leads to Increased Susceptibility to Diet-Induced Obesity. [PDF]
, 2019 (1) Background: Paraoxonase 2 (PON2) is a ubiquitously expressed protein localized to endoplasmic reticulum and mitochondria. Previous studies have shown that PON2 exhibits anti-oxidant and anti-inflammatory functions, and PON2-deficient (PON2-def) mice ...
Fogelman, Alan M +9 more
core +1 more source
Serum paraoxonase 1 activity and protein N-homocysteinylation in primary human endometrial cancer
Tumor Biology, 2018 Paraoxonase 1 plays an important role in protection from oxidative stress and also decomposes homocysteine thiolactone, the toxic metabolite of homocysteine.
Krzysztof Gałczyński +5 more
doaj +1 more source
Oral chondroitin sulfate and prebiotics for the treatment of canine Inflammatory Bowel Disease: a randomized, controlled clinical trial [PDF]
, 2016 BACKGROUND Canine inflammatory bowel disease (IBD) is a chronic enteropathy of unknown etiology, although microbiome dysbiosis, genetic susceptibility, and dietary and/or environmental factors are hypothesized to be involved in its pathogenesis. Since
A Ghiselli +51 more
core +6 more sources
Paraoxonase Activity in Glomerulonephritic Patients [PDF]
Renal Failure, 2007 Cardiovascular disease is the most common cause of morbidity and mortality in patients with chronic renal failure. Glomerulonephritic patients have an increased risk for cardiovascular disease, but its etiology is unclear. It is known that an increase in oxidizability of apolipoprotein B-containing lipoproteins has a key role in the initiation of ...
Dirican, MELEHAT +9 more
openaire +4 more sources
Determination of Some Biochemical Parameters of Patients with Hepatitis B in Kirkuk City [PDF]
Kirkuk Journal of Science, 2018 Hepatitis B infection is a worldwide healthcare problem, especially in developing areas. The current study was to evaluate the alterations in different biochemical parameters including paraoxonase (PON), 5′-Nucleotidase (5NT), total bilirubin, direct ...
Entedhar R. Sarhat, Nawal A. Al- Madany
doaj +1 more source
Depletion of B-cells with rituximab improves endothelial function and reduces inflammation among individuals with rheumatoid arthritis. [PDF]
, 2014 BackgroundIndividuals with rheumatoid arthritis (RA) are at increased risk for cardiovascular disease, partly due to systemic inflammation and endothelial dysfunction.
Del Puerto, Gus +10 more
core +2 more sources
Paraoxonase 1 Activity and its Polymorphism in Type 2 Diabetic Nephropathy
Endocrinology Research and Practice, 2018 Objective: This study aims to investigate the role of paraoxonase 1 activity and Q192R polymorphism in the development of nephropathy in patients with Type 2 diabetes mellitus.
Mukund R. MOGAREKAR +2 more
doaj +1 more source
Statins in Breast Cancer Therapy: Mechanistic Insights and Emerging Evidence. [PDF]
Cancer InnovStatins, particularly simvastatin, demonstrate potential as adjuvant agents in breast cancer treatment by disrupting tumour cell signalling and survival pathways. This review highlights emerging evidence supporting their repurposing for improved outcomes, especially in aggressive breast cancer subtypes.
Alim R, Akalanka HMK.
europepmc +2 more sources
PON1 status does not influence cholinesterase activity in Egyptian agricultural workers exposed to chlorpyrifos. [PDF]
, 2012 Animal studies have shown that paraoxonase 1 (PON1) genotype can influence susceptibility to the organophosphorus pesticide chlorpyrifos (CPF). However, Monte Carlo analysis suggests that PON1 genotype may not affect CPF-related toxicity at low exposure ...
Bonner, Matthew R +6 more
core +1 more source
Antioxidants, 2023 Exercise may increase the antioxidant capacity of plasma by stimulating antioxidant enzymes. The study aimed to measure the effect of three repetitions of acute exercise on arylesterase (ARE) activity of the paraoxonase 1 (PON1) enzyme.
Aneta Otocka-Kmiecik +6 more
doaj +1 more source