Results 11 to 20 of about 16,132 (204)
Balkan Medical Journal, 2017 Background: Apolipoprotein A-1, paraoxonase-1 and paraoxonase-3 are antioxidant and anti-atherosclerotic structural high-density lipoprotein proteins that are mainly synthesized by the liver.
Gülben Sayılan Özgün +5 more
doaj +2 more sources
Purification of Human Serum Paraoxonase and Effect of Acetylsalicylic Acid on Paraoxonase Activity [PDF]
Pharmaceutical Biology, 2008 AbstractParaoxonase was purified from human serum using sepharose-4B-l-tyrosine-1-napthylamine affinity chromatography. This enzyme was purified 1797-fold. SDS-polyacrylamide electrophoresis of the enzyme indicates a single protein staining band with an apparent Mr of 43 kDa. The kinetic properties of the purified enzyme were determined.
Demir, Yasar +2 more
openaire +3 more sources
Paraoxonase and arylesterase activities in fibromyalgia [PDF]
Redox Report, 2007 We aimed to evaluate the association of serum paraoxonase and arylesterase activities and oxidative/antioxidative status in patients with fibromyalgia. Forty-two patients with fibromyalgia and 53 healthy controls were included in the study. Serum paraoxonase and arylesterase activities were measured spectrophotometrically.
Altindag, O. +5 more
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Effect of Glimepiride on Paraoxonase Activity
Pharmaceutical Biology, 2006 AbstractIn this study, the effect of glimepiride on serum paraoxonase activity (EC 3.1.8.1.) has been investigated in vitro.. The inhibition and activation effects of this drug on serum paraoxonase activity was measured spectrophotometrically using paraoxon as the substrate.
Nadaroglu, H, Demir, Y, Demir, N
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Paraoxonase and Atherosclerosis [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2001 Abstract—There is considerable evidence that the antioxidant activity of high density lipoprotein (HDL) is largely due to the paraoxonase-1 (PON1) located on it. Experiments with transgenic PON1 knockout mice indicate the potential for PON1 to protect against atherogenesis.
P N, Durrington +2 more
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Evaluation of Oxidative Stress Parameters and Antioxidant Status in Coronary Artery Disease Patients [PDF]
Archives of Razi Institute, 2022 A surge in oxidative stress and weakened antioxidant defense contributes to the initiation and progression of Coronary Artery Diseases (CAD). The resultant burst in free radicals causes oxidation of lipoproteins mainly oxidized low-density lipoprotein ...
S Varadhan +3 more
doaj +1 more source
Evidence of Paraoxonases 1, 2, and 3 Expression in Human Ovarian Granulosa Cells
Antioxidants, 2021 Increasing evidence suggests that the antioxidant paraoxonase proteins, PON1, PON2, and PON3, have a role in reproduction and may be synthesized by ovarian cells.
Irantzu Pérez-Ruiz +6 more
doaj +1 more source
Serum paraoxonase level and paraoxonase polymorphism in patients with acromegaly [PDF]
Redox Report, 2016 Acromegalic patients have increased cardiometabolic risk factors due to an elevation of growth hormone (GH) levels. Human serum paraoxonase (PON), a high-density lipoprotein (HDL)-related enzyme, is one of the major bioscavengers and decreases the oxidation of low-density lipoprotein (LDL), a key regulator in the pathogenesis of atherosclerosis.
Murat Can +8 more
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Paraoxonase 1 and atherosclerosis
Frontiers in Cardiovascular Medicine, 2023 Paraoxonase 1 (PON1), residing almost exclusively on HDL, was discovered because of its hydrolytic activity towards organophosphates. Subsequently, it was also found to hydrolyse a wide range of substrates, including lactones and lipid hydroperoxides.
Paul N. Durrington +4 more
openaire +3 more sources
Regulatory Mechanisms in Biosystems, 2018 Nowadays low paraoxonase activity is generally recognized as an independent risk factor of cardiovascular diseases involved in pathologic remodeling of the heart and vessels as well as thrombosis in the general population.
S. V. Shevchuk +4 more
doaj +1 more source