Results 11 to 20 of about 23,747 (229)

Paraoxonase and Atherosclerosis [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2001
Abstract—There is considerable evidence that the antioxidant activity of high density lipoprotein (HDL) is largely due to the paraoxonase-1 (PON1) located on it. Experiments with transgenic PON1 knockout mice indicate the potential for PON1 to protect against atherogenesis.
P N, Durrington, B, Mackness, M I, Mackness   +2 more
openaire   +2 more sources

Paraoxonase 1 and atherosclerosis

Frontiers in Cardiovascular Medicine, 2023
Paraoxonase 1 (PON1), residing almost exclusively on HDL, was discovered because of its hydrolytic activity towards organophosphates. Subsequently, it was also found to hydrolyse a wide range of substrates, including lactones and lipid hydroperoxides.
Paul N. Durrington, Bilal Bashir, Bilal Bashir, Handrean Soran, Handrean Soran   +4 more
openaire   +3 more sources

Preferential inhibition of paraoxonase activity of human paraoxonase 1 by negatively charged lipids

Journal of Lipid Research, 2004
To determine the causes responsible for a preferential decrease of paraoxonase activity, which has been observed in the serum of patients with cardiovascular diseases, the inactivation or inhibition of paraoxonase 1 (PON1) by various endogenous factors ...
Su Duy Nguyen, Dai-Eun Sok
doaj   +1 more source

Paraoxonase 2 overexpression inhibits tumor development in a mouse model of ovarian cancer. [PDF]

, 2018
Ovarian cancer (OC) is most lethal malignancy among all gynecological cancer. Large bodies of evidences suggest that mitochondrial-derived ROS play a critical role in the development and progression of OC.
Devarajan, Asokan, Farias-Eisner, Gina, Farias-Eisner, Robin, Fogelman, Alan M, Gao, Feng, Grijalva, Victor, Nwokedi, Josephine, Reddy, Srinivasa T, Su, Feng, Trost, Hannah, Yalamanchi, Ashna, Yalamanchi, Meghna   +11 more
core   +3 more sources

Human paraoxonase 2

EXCLI journal, 2011
Human paraoxonase 2 (PON2), which is a member of the paraoxonase family, possesses unique properties that distinguish it from PON1 and PON3. PON2 is ubiquitously expressed in many different tissue types and is highly expressed in the vital organs, such as the heart and lungs.
Permpongpaiboon, Thinnakorn, Porntadavity, Sureerut, Sukketsiri, Wanida   +2 more
openaire   +3 more sources

Serum paraoxonase activity in patients with rheumatoid arthritis, its relationship with the clinical course and cardiovascular compications

Regulatory Mechanisms in Biosystems, 2018
Nowadays low paraoxonase activity is generally recognized as an independent risk factor of cardiovascular diseases involved in pathologic remodeling of the heart and vessels as well as thrombosis in the general population.
S. V. Shevchuk, Y. S. Seheda, O. Y. Galyutina, N. P. Masik, O. V. Shevchuk   +4 more
doaj   +1 more source

Native High-Density Lipoproteins (HDL) with Higher Paraoxonase Exerts a Potent Antiviral Effect against SARS-CoV-2 (COVID-19), While Glycated HDL Lost the Antiviral Activity

Antioxidants, 2021
Human high-density lipoproteins (HDL) show a broad spectrum of antiviral activity in terms of anti-infection. Although many reports have pointed out a correlation between a lower serum HDL-C and a higher risk of COVID-19 infection and progression, the in
Kyung-Hyun Cho, Jae-Ryong Kim, In-Chul Lee, Hyung-Jun Kwon   +3 more
doaj   +1 more source

Serum paraoxonase level and paraoxonase polymorphism in patients with acromegaly [PDF]

Redox Report, 2016
Acromegalic patients have increased cardiometabolic risk factors due to an elevation of growth hormone (GH) levels. Human serum paraoxonase (PON), a high-density lipoprotein (HDL)-related enzyme, is one of the major bioscavengers and decreases the oxidation of low-density lipoprotein (LDL), a key regulator in the pathogenesis of atherosclerosis.
Murat Can, Furuzan Kokturk, Ayse C. Hamamcioglu, Esra Ermiş, Taner Bayraktaroglu, Fatih Kuzu, Dilek Arpaci, Ahmet Dursun, Sevim Karakas Celik   +8 more
openaire   +3 more sources

Extended-release niacin increases anti-apolipoprotein A-I antibodies that block the antioxidant effect of high-density lipoprotein-cholesterol: the EXPLORE clinical trial. [PDF]

, 2017
Extended-release niacin (ERN) is the most effective agent for increasing high-density lipoprotein-cholesterol (HDL-C). Having previously identified anti-HDL antibodies, we investigated whether ERN affected the antioxidant capacity of HDL and whether ERN ...
Alves, JD, Amaral, M, Ames, P, Batuca, J, Favas, C, Papoila, A, Paula, F   +6 more
core   +1 more source

Total oxidative stress, paraoxonase and arylesterase levels at patients with pseudoexfoliation syndrome and pseudoexfoliative glaucoma [PDF]

International Journal of Ophthalmology, 2015
AIM:To investigate the oxidative stress status of the aqueous humor and serum of patients with pseudoexfoliation (PEX) syndrome and pseudoexfoliative glaucoma (PEG) and to measure paraoxonase (PON) and arylesterase (ARE) levels.METHODS: A total of 78 ...
Feyza Dursun, Ayse Vural Ozec, Huseyin Aydin, Aysen Topalkara, Ayhan Dursun, Mustafa Ilker Toker, Haydar Erdogan, Mustafa Kemal Arici   +7 more
doaj   +1 more source