Results 11 to 20 of about 16,692 (213)

Purification of Human Serum Paraoxonase and Effect of Acetylsalicylic Acid on Paraoxonase Activity [PDF]

Pharmaceutical Biology, 2008
AbstractParaoxonase was purified from human serum using sepharose-4B-l-tyrosine-1-napthylamine affinity chromatography. This enzyme was purified 1797-fold. SDS-polyacrylamide electrophoresis of the enzyme indicates a single protein staining band with an apparent Mr of 43 kDa. The kinetic properties of the purified enzyme were determined.
Demir, Yasar, Demir, Nazan, NADAROĞLU, Hayrunnisa   +2 more
openaire   +3 more sources

Low Serum Paraoxonase-1 Lactonase and Arylesterase Activities in Obese Children and Adolescents

Romanian Journal of Laboratory Medicine, 2015
Serum paraoxonase-1 (PON1) binds mainly to high density lipoproteins (HDLs) and protects low density lipoproteins (LDLs) against oxidation. While paraoxonase and arylesterase activities are traditionally assayed, lactonase activity, accounting for ...
Sandor Raluca, Leucuta Daniel, Dronca Eleonora, Niculae Alexandru, Cret Victoria, Silaghi Ciprian, Suciu Soimita   +6 more
doaj   +2 more sources

The Structure and Function of Paraoxonase-1 and Its Comparison to Paraoxonase-2 and -3 [PDF]

Molecules, 2020
Serum paraoxonase-1 (PON1) is the most studied member of the group of paraoxonases (PONs). This enzyme possesses three enzymatic activities: lactonase, arylesterase, and paraoxonase activity.
Ajda Taler-Verčič, Marko Goličnik, Aljoša Bavec   +2 more
doaj   +4 more sources

Effect of Glimepiride on Paraoxonase Activity

Pharmaceutical Biology, 2006
AbstractIn this study, the effect of glimepiride on serum paraoxonase activity (EC 3.1.8.1.) has been investigated in vitro.. The inhibition and activation effects of this drug on serum paraoxonase activity was measured spectrophotometrically using paraoxon as the substrate.
Nadaroglu, H, Demir, Y, Demir, N
openaire   +3 more sources

Paraoxonase and Atherosclerosis [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2001
Abstract—There is considerable evidence that the antioxidant activity of high density lipoprotein (HDL) is largely due to the paraoxonase-1 (PON1) located on it. Experiments with transgenic PON1 knockout mice indicate the potential for PON1 to protect against atherogenesis.
P N, Durrington, B, Mackness, M I, Mackness   +2 more
openaire   +2 more sources

Marked Long-Term Improvement in Lung Function in Melanoma Differentiation-Associated Protein 5 Antibody-Positive Dermatomyositis Patients: Experience of a Single-Center Longitudinal Cohort in North America. [PDF]

Arthritis Care Res (Hoboken)
Objective The objective of this study was to describe the longitudinal disease course and pulmonary outcomes of North American patients with melanoma differentiation–associated protein 5 (MDA5) antibody–associated dermatomyositis (DM). Methods Thirty patients with MDA5 antibody–associated DM were identified in a single‐center longitudinal cohort of 352
Cheah JX, Bae SS, De Leon T, Lee Y, Guo R, Elashoff D, Wang J, Shahbazian A, Charles-Schoeman C.   +8 more
europepmc   +2 more sources

Serum paraoxonase level and paraoxonase polymorphism in patients with acromegaly [PDF]

Redox Report, 2016
Acromegalic patients have increased cardiometabolic risk factors due to an elevation of growth hormone (GH) levels. Human serum paraoxonase (PON), a high-density lipoprotein (HDL)-related enzyme, is one of the major bioscavengers and decreases the oxidation of low-density lipoprotein (LDL), a key regulator in the pathogenesis of atherosclerosis.
Murat Can, Furuzan Kokturk, Ayse C. Hamamcioglu, Esra Ermiş, Taner Bayraktaroglu, Fatih Kuzu, Dilek Arpaci, Ahmet Dursun, Sevim Karakas Celik   +8 more
openaire   +3 more sources

Paraoxonase 1 and atherosclerosis

Frontiers in Cardiovascular Medicine, 2023
Paraoxonase 1 (PON1), residing almost exclusively on HDL, was discovered because of its hydrolytic activity towards organophosphates. Subsequently, it was also found to hydrolyse a wide range of substrates, including lactones and lipid hydroperoxides.
Paul N. Durrington, Bilal Bashir, Bilal Bashir, Handrean Soran, Handrean Soran   +4 more
openaire   +3 more sources

Serum paraoxonase activity in patients with rheumatoid arthritis, its relationship with the clinical course and cardiovascular compications

Regulatory Mechanisms in Biosystems, 2018
Nowadays low paraoxonase activity is generally recognized as an independent risk factor of cardiovascular diseases involved in pathologic remodeling of the heart and vessels as well as thrombosis in the general population.
S. V. Shevchuk, Y. S. Seheda, O. Y. Galyutina, N. P. Masik, O. V. Shevchuk   +4 more
doaj   +1 more source

Native High-Density Lipoproteins (HDL) with Higher Paraoxonase Exerts a Potent Antiviral Effect against SARS-CoV-2 (COVID-19), While Glycated HDL Lost the Antiviral Activity

Antioxidants, 2021
Human high-density lipoproteins (HDL) show a broad spectrum of antiviral activity in terms of anti-infection. Although many reports have pointed out a correlation between a lower serum HDL-C and a higher risk of COVID-19 infection and progression, the in
Kyung-Hyun Cho, Jae-Ryong Kim, In-Chul Lee, Hyung-Jun Kwon   +3 more
doaj   +1 more source