Results 1 to 10 of about 3,803 (163)

Arylesterase Activity of Paraoxonase-1 in Serum and Cerebrospinal Fluid of Patients with Alzheimer’s Disease and Vascular Dementia

Antioxidants, 2020
Background: It has been suggested that circulating Paraoxonase-1 (PON1) and apolipoprotein A1 (APOA1), which closely interacts with the antioxidant enzyme, could be implicated in Alzheimer’s disease (AD) and vascular dementia (VaD) development.
Tiziana Bellini, Arianna Romani, Wiesje van der Flier   +2 more
exaly   +4 more sources

Reevaluation of Serum Arylesterase Activity in Neurodevelopmental Disorders [PDF]

Antioxidants, 2021
Organophosphate compounds (OPs) interfere with neurodevelopment and are neurotoxic for humans and animals. They are first biotransformed to the more toxic oxon form, and then hydrolyzed to specific metabolites by the enzyme paraoxonase/arylesterase ...
Ignazio Stefano Piras, Stefano Gabriele, Laura Altieri, Federica Lombardi, Roberto Sacco, Carla Lintas, Barbara Manzi, Paolo Curatolo, Maria Nobile, Catia Rigoletto, Massimo Molteni, Antonio M. Persico   +11 more
doaj   +3 more sources

Gut Bacterium Lysinibacillus Sphaericus Exacerbates Aspirin-induced Intestinal Injury by Production of Carboxylesterase EstB. [PDF]

Adv Sci (Weinh)
Schematic overview illustrating the detrimental role of gut microbiota in aspirin‐induced intestinal injury. L. sphaericus and its secreted carboxylesterase EstB are identified as key drivers that catalyze aspirin hydrolysis into salicylic acid, thereby exacerbating intestinal injury. Inhibition of EstB by the dietary compound flavanomarein effectively
Zhao Z, Li Q, Bai X, Zhai E, Dai W, Qian Y, Zhang T, Huang Z, Huang Z, Meng F, Chen J, Zuo T, Cai S, Zhao R.   +13 more
europepmc   +2 more sources

Oestrogen receptor phosphorylation profiles and in silico PAM50 subtyping reflect sexual dimorphism in breast cancer. [PDF]

J Pathol Clin Res
Abstract Breast cancer (BC) is most prevalent in females but also accounts for <1% of male cancer cases and 0.2% of male cancer‐related deaths. Distribution of histological subtypes, receptor status, and age of diagnosis varies based on sex, and a growing body of evidence supports sex‐specific molecular differences in BC.
Chatterji S, Diack A, Szostok M, Morgan MD, Silvestri V, Ottini L, Moelans CB, van Diest PJ, Selli C, Sims AH, Abu-Eid R, Speirs V.   +11 more
europepmc   +2 more sources

Noncatalytic Functions Are Required for MPO and PON1 in Modulating the Involvement of Monocytes and Endothelial Cells in Atherosclerosis. [PDF]

Biochem Res Int
High‐density lipoproteins (HDLs) are deeply implicated in atherosclerosis. HDL, myeloperoxidase (MPO), and paraoxonase‐1 (PON1) form a functional ternary complex where PON1 partially inhibits the MPO activity, and MPO in turn partially inactivates PON1.
Li Y, Liu Y, Cheng Y.
europepmc   +2 more sources

Functional, Structural and Genetic Modulation in Plasma and Renal Antioxidant Systems by Quercetin, Catechin and Genistein in Cisplatin-Induced Acute Nephrotoxicity in Wistar Rats. [PDF]

Food Sci Nutr
Cisplatin administration increases production of reactive oxygen species (ROS) as indicated by increased plasma renal biomarkers (KIM‐1, Cys‐C, BUN, CR), cellular damage indicators (MDA, AOPP, 8‐OHdG) and histopathology of kidney. Co‐exposure along with quercetin, catechin and genistein restored the renal functions which may be due to direct ROS ...
Verma PK, Sharma P, Tukra S, Singh B, Sood S, Pankaj NK, Brahma B, Abdi G, Bhat ZF.   +8 more
europepmc   +2 more sources

Effect of Exercise Repetitions on Arylesterase Activity of PON1 in Plasma of Average-Trained Men—The Dissociation between Activity and Concentration

Antioxidants, 2023
Exercise may increase the antioxidant capacity of plasma by stimulating antioxidant enzymes. The study aimed to measure the effect of three repetitions of acute exercise on arylesterase (ARE) activity of the paraoxonase 1 (PON1) enzyme.
Aneta Otocka-Kmiecik, Monika Orłowska-Majdak, Robert Stawski, Urszula Szkudlarek, Gianluca Padula, Szymon Gałczyński, Dariusz Nowak   +6 more
doaj   +1 more source

Total oxidative stress, paraoxonase and arylesterase levels at patients with pseudoexfoliation syndrome and pseudoexfoliative glaucoma [PDF]

International Journal of Ophthalmology, 2015
AIM:To investigate the oxidative stress status of the aqueous humor and serum of patients with pseudoexfoliation (PEX) syndrome and pseudoexfoliative glaucoma (PEG) and to measure paraoxonase (PON) and arylesterase (ARE) levels.METHODS: A total of 78 ...
Feyza Dursun, Ayse Vural Ozec, Huseyin Aydin, Aysen Topalkara, Ayhan Dursun, Mustafa Ilker Toker, Haydar Erdogan, Mustafa Kemal Arici   +7 more
doaj   +1 more source

Association between inflammatory markers and serum paraoxonase and arylesterase activities in the general population: a cross-sectional study

Lipids in Health and Disease, 2021
Background Recent studies focused on modulating factors of paraoxonase-1 (PON1) activity. In some studies the association between pro-inflammatory markers and PON1 activity was examined, but so far no population-based investigations on this issue have ...
Christa Meisinger, Dennis Freuer, Achim Bub, Jakob Linseisen   +3 more
doaj   +1 more source

Paraoxonase/Arylesterase Activity of Serum Paraoxonase-1 and Schizophrenia: A Systematic Review and Meta-Analysis

Antioxidants, 2023
The presence of a pro-oxidant state in patients with schizophrenia may account for the increased risk of atherosclerosis and cardiovascular disease in this group and supports the potential utility of circulating biomarkers of oxidative stress for risk ...
Angelo Zinellu, Stefania Sedda, Arduino A. Mangoni   +2 more
doaj   +1 more source