Results 1 to 10 of about 27,543,966 (172)
Paraoxonase 1 and atherosclerosis [PDF]
Frontiers in Cardiovascular Medicine, 2023 Paraoxonase 1 (PON1), residing almost exclusively on HDL, was discovered because of its hydrolytic activity towards organophosphates. Subsequently, it was also found to hydrolyse a wide range of substrates, including lactones and lipid hydroperoxides ...
Paul N. Durrington +4 more
doaj +3 more sources
Phytochemicals as Modulators of Paraoxonase-1 in Health and Diseases
Antioxidants, 2022 Chronic diseases such as cardiovascular disease (CVD), atherosclerosis, chronic liver disease, and neurodegenerative diseases are major causes of mortality.
Amirhossein Sahebkar +2 more
exaly +4 more sources
The Relationship between Cancer and Paraoxonase 1
Antioxidants, 2022 Extensive research has been carried out to understand and elucidate the mechanisms of paraoxonase 1 (PON1) in the development of diseases including cancer, cardiovascular diseases, neurological diseases, and inflammatory diseases.
Irma Martha Medina-Díaz +7 more
doaj +2 more sources
Proteomic Exploration of Paraoxonase 1 Function in Health and Disease. [PDF]
Int J Mol Sci, 2023 High-density lipoprotein (HDL) exhibits cardio- and neuro-protective properties, which are thought to be promoted by paraoxonase 1 (PON1), a hydrolytic enzyme associated with an HDL subfraction also enriched with an anticoagulant protein (PROS1) and ...
Jakubowski H.
europepmc +2 more sources
The Molecular Bases of Anti-Oxidative and Anti-Inflammatory Properties of Paraoxonase 1. [PDF]
Antioxidants (Basel)The anti-oxidative and anti-inflammatory properties of high-density lipoprotein (HDL) are thought to be mediated by paraoxonase 1 (PON1), a calcium-dependent hydrolytic enzyme carried on a subfraction of HDL that also carries other anti-oxidative and ...
Jakubowski H.
europepmc +2 more sources
Paraoxonase 1 and Non-Alcoholic Fatty Liver Disease: A Meta-Analysis
Molecules, 2021 Oxidative stress is involved in the pathophysiology of nonalcoholic fatty liver disease (NAFLD). However, reliable biomarkers of NAFLD in relation to oxidative stress are not available.
Kazuhiko Kotani +3 more
doaj +2 more sources
The Structure and Function of Paraoxonase-1 and Its Comparison to Paraoxonase-2 and -3
Molecules, 2020 Serum paraoxonase-1 (PON1) is the most studied member of the group of paraoxonases (PONs). This enzyme possesses three enzymatic activities: lactonase, arylesterase, and paraoxonase activity.
Ajda Taler-Verčič +2 more
exaly +2 more sources
Preferential inhibition of paraoxonase activity of human paraoxonase 1 by negatively charged lipids
Journal of Lipid Research, 2004 To determine the causes responsible for a preferential decrease of paraoxonase activity, which has been observed in the serum of patients with cardiovascular diseases, the inactivation or inhibition of paraoxonase 1 (PON1) by various endogenous factors ...
Dai-Eun Sok, Su Duy Nguyen
exaly +3 more sources
Systematic Reviews, 2020 Environmental factors such as pollution, pesticide exposure and socio-demographic location have been implicated as a pressure capable of altering genetic make-up.
Nkosinathi Banhela +2 more
doaj +2 more sources
International Journal of Environmental Research and Public Health, 2023 Paraoxonase-1 (PON1) is a calcium-dependent, HDL-bound serum hydrolase active toward a wide variety of substrates. PON1 displays three types of activities, among which lactonase, paraoxonase, arylesterase and phosphotriesterase can be distinguished.
Dominika Kunachowicz +2 more
semanticscholar +1 more source