Phytochemicals as Modulators of Paraoxonase-1 in Health and Diseases
Antioxidants, 2022 Chronic diseases such as cardiovascular disease (CVD), atherosclerosis, chronic liver disease, and neurodegenerative diseases are major causes of mortality.
Zahra Najafi Arab +11 more
doaj +1 more source
Plasma total antioxidant capacity and peroxidation biomarkers in psoriasis [PDF]
, 2016 Systemic biomarkers of oxidative stress can be relevant for assessment of psoriasis severity, for prediction of the outcome of therapy and of the development of comorbidities.
Cavaliere, Arturo +2 more
core +2 more sources
Serum paraoxonase 1 activity and protein N-homocysteinylation in primary human endometrial cancer
Tumor Biology, 2018 Paraoxonase 1 plays an important role in protection from oxidative stress and also decomposes homocysteine thiolactone, the toxic metabolite of homocysteine.
Krzysztof Gałczyński +5 more
doaj +1 more source
PON1 status does not influence cholinesterase activity in Egyptian agricultural workers exposed to chlorpyrifos. [PDF]
, 2012 Animal studies have shown that paraoxonase 1 (PON1) genotype can influence susceptibility to the organophosphorus pesticide chlorpyrifos (CPF). However, Monte Carlo analysis suggests that PON1 genotype may not affect CPF-related toxicity at low exposure ...
Bonner, Matthew R +6 more
core +1 more source
Preferential inhibition of paraoxonase activity of human paraoxonase 1 by negatively charged lipids
Journal of Lipid Research, 2004 To determine the causes responsible for a preferential decrease of paraoxonase activity, which has been observed in the serum of patients with cardiovascular diseases, the inactivation or inhibition of paraoxonase 1 (PON1) by various endogenous factors ...
Su Duy Nguyen, Dai-Eun Sok
doaj +1 more source
The Role of PON1 Variants in Disease Susceptibility in a Turkish Population
Global Medical Genetics, 2020 Paraoxonase 1 (PON1) enzyme plays a major role in antioxidant defense and protects the cells against reactive species. The most common PON1 Q192R and L55M polymorphisms are responsible for a wide variation of PON1 activity, which showed an up to 13-fold ...
Mahmoud Abudayyak +4 more
doaj +1 more source
Paraoxonase 1 and Non-Alcoholic Fatty Liver Disease: A Meta-Analysis
Molecules, 2021 Oxidative stress is involved in the pathophysiology of nonalcoholic fatty liver disease (NAFLD). However, reliable biomarkers of NAFLD in relation to oxidative stress are not available.
Kazuhiko Kotani +3 more
doaj +1 more source
Paraoxonase 2 overexpression inhibits tumor development in a mouse model of ovarian cancer. [PDF]
, 2018 Ovarian cancer (OC) is most lethal malignancy among all gynecological cancer. Large bodies of evidences suggest that mitochondrial-derived ROS play a critical role in the development and progression of OC.
Devarajan, Asokan +11 more
core +3 more sources
Study of Paraoxonase 1 (PON1) Activity as an Independent Risk Factor in Coronary Artery Disease [PDF]
National Journal of Laboratory Medicine, 2013 Background: Coronary Artery Disease is the major cause of mortality and morbidity worldwide. Human serum paraoxonase-1 is a high density lipoprotein bound enzyme exhibiting antiatherogenic properties.
Sangita M. Patil +7 more
doaj +1 more source
Study the levels of Leptin, and Adiponectin with Paraoxonase in Obese Individuals (male & female)
Tikrit Journal of Pure Science, 2023 Obesity is a well-known risk factor of metabolic complications and cardiovascular disease. Associations between anthropometric measurements and fat distribution and risk factors for cardiovascular disease have been demonstrated in several populations.
Entedhar R. Sarhat
doaj +1 more source