Results 21 to 30 of about 107,672,034 (158)

Paraoxonase 1 in Chronic Kidney Failure [PDF]

Journal of Lipids, 2012
In this review we summarize the findings from the literature and our own laboratory on the decreased PON1 activity in renal failure, the mechanisms proposed and the effect of interventions. In addition to profound alterations in lipoproteins, reduced serum PON1 activity has been clearly established in the past decade and could contribute to accelerated
Alejandro Gugliucci, Kazuhiko Kotani, Satoshi Kimura   +2 more
openaire   +2 more sources

Interactions of Paraoxonase-1 with Pharmacologically Relevant Carbamates [PDF]

Molecules, 2020
Mammalian paraoxonase-1 hydrolyses a very broad spectrum of esters such as certain drugs and xenobiotics. The aim of this study was to determine whether carbamates influence the activity of recombinant PON1 (rePON1). Carbamates were selected having a variety of applications: bambuterol and physostigmine are drugs, carbofuran is used as a pesticide ...
Anita Bosak, Aljoša Bavec, Tilen Konte, Goran Šinko, Zrinka Kovarik, Marko Goličnik   +5 more
openaire   +5 more sources

Relationship of serum paraoxonase 1 activity and paraoxonase 1 genotype to risk of systemic lupus erythematosus [PDF]

Arthritis & Rheumatism, 2006
AbstractObjectiveLow serum paraoxonase 1 (PON1) activity determined with paraoxon as substrate has been found to be associated with coronary artery disease. This study was undertaken to examine the relationship of PON1 activity and genotype to risk of systemic lupus erythematosus (SLE).MethodsThe impact of 7 PON1 single‐nucleotide polymorphisms (SNPs ...
Laura M, Tripi, Susan, Manzi, Qi, Chen, Margaret, Kenney, Penny, Shaw, Amy, Kao, Franklin, Bontempo, Candace, Kammerer, M Ilyas, Kamboh   +8 more
openaire   +2 more sources

Correlation of Paraoxonase-1 with the Severity of Crohn’s Disease [PDF]

Molecules, 2018
Diagnostics of Crohn’s disease (CD) requires noninvasive biomarkers facilitating early detection and differentiation of the disease. Therefore, in this study, we aimed to determine the relationship between paraoxonase-1 (PON-1), the severity of CD, oxidative stress, and inflammation in CD.
Katarzyna Szczeklik, Tomasz Mach, Dorota Cibor, Danuta Owczarek, Jacek Sapa, Monika Papież, Jolanta Pytko-Polończyk, Wirginia Krzyściak   +7 more
openaire   +5 more sources

The Role of PON1 Variants in Disease Susceptibility in a Turkish Population

Global Medical Genetics, 2020
Paraoxonase 1 (PON1) enzyme plays a major role in antioxidant defense and protects the cells against reactive species. The most common PON1 Q192R and L55M polymorphisms are responsible for a wide variation of PON1 activity, which showed an up to 13-fold ...
Mahmoud Abudayyak, Tuğçe Boran, Rumeysa Tukel, Ezgi Oztas, Gül Özhan   +4 more
doaj   +1 more source

Paraoxonase 1 and Non-Alcoholic Fatty Liver Disease: A Meta-Analysis

Molecules, 2021
Oxidative stress is involved in the pathophysiology of nonalcoholic fatty liver disease (NAFLD). However, reliable biomarkers of NAFLD in relation to oxidative stress are not available.
Kazuhiko Kotani, Jun Watanabe, Kouichi Miura, Alejandro Gugliucci   +3 more
doaj   +1 more source

Study of Paraoxonase 1 (PON1) Activity as an Independent Risk Factor in Coronary Artery Disease [PDF]

National Journal of Laboratory Medicine, 2013
Background: Coronary Artery Disease is the major cause of mortality and morbidity worldwide. Human serum paraoxonase-1 is a high density lipoprotein bound enzyme exhibiting antiatherogenic properties.
Sangita M. Patil, Mangesh P. Banker, Ramchandra K. Padalkar, Abhijit P. Pathak, Shital Ghodke, Anjali S. Phatake , Sonali S. Bhagat, Rahul A. Ghone   +7 more
doaj   +1 more source

Study the levels of Leptin, and Adiponectin with Paraoxonase in Obese Individuals (male & female)

Tikrit Journal of Pure Science, 2023
Obesity is a well-known risk factor of metabolic complications and cardiovascular disease. Associations between anthropometric measurements and fat distribution and risk factors  for cardiovascular disease have been demonstrated in several populations.
Entedhar R. Sarhat
doaj   +1 more source

Paraoxonase 1 as an important antiatherogenic agent

Journal of Education, Health and Sport, 2019
The inverse relationship between High Density Lipoproteins (HDL) level and risk of ischaemic heart disease was proved by many epidemiological studies. Although the main mechanism of antiatherogenic activity of HDL is a reverse transport of cholesterol ...
Ewa Lidia Krzewicka-Romaniuk, Dagna Agnieszka Siedlecka, Anna Warpas, Grażyna Wójcicka   +3 more
doaj   +3 more sources

Decrease Paraoxonase-1 (PON-1) Activities in Neurodegenerative Diseases

, 2016
Decrease Paraoxonase-1 (PON-1) Activities in Neurodegenerative ...
Cervellati, Carlo, Giovanni Zuliani, Fainardi, Enrico, Giuseppe Valacchi, Angelina Passaro, Castellazzi, Massimiliano, Arianna Romani, Trentini, Alessandro, Zuliani, Giovanni, Carlo Cervellati, Romani, Arianna, Alessandro Trentini, Bellini, Tiziana, Tiziana Bellini, Massimiliano Castellazzi, Valacchi, Giuseppe, Enrico Fainardi, Passaro, Angelina   +17 more
core   +1 more source