Results 21 to 30 of about 29,702,919 (206)

Tetranectin and Paraoxonase-1 as Markers of Heart Failure. [PDF]

Medicina (Kaunas)
Background and Objectives: This narrative review evaluates the potential of Tetranectin (TN) and Paraoxonase-1 (PON1) to bridge the gap between biological pathology and clinical risk stratification by mapping the “Fibrosis-Oxidative Axis”. Materials and Methods: A targeted literature search was conducted using Scopus, PubMed, and Google Scholar to ...
Vulciu PA, Valea NC, Zdremtan D, Alexandru C, Varga NI, Donath-Miklos I, Mot MD, Puschita M.   +7 more
europepmc   +3 more sources

Paraoxonase 1 status in the Thai population [PDF]

Journal of Human Genetics, 2005
Human serum paraoxonase 1 (PON1), a high-density lipoprotein (HDL)-associated enzyme, has been shown to reduce the oxidation of low-density lipoprotein (LDL) and HDL by degrading lipid peroxides. This property of PON1 accounts for its ability to protect against atherosclerosis.
Wimon, Phuntuwate, Chuthamanee, Suthisisang, Banhan, Koanantakul, Michael I, Mackness, Bharti, Mackness   +4 more
openaire   +2 more sources

Haplotype-Phenotype Relationships of Paraoxonase-1 [PDF]

Cancer Epidemiology, Biomarkers & Prevention, 2005
Abstract Paraoxonase 1 (PON1) is an enzyme with multiple activities, including detoxification of organophosphates. It is believed to be important in preventing neurotoxic damage and has also been implicated in atherosclerosis. The PON1 gene contains five common polymorphisms, three in the promoter (−909G > C, −162A > G ...
Jia, Chen, Wendy, Chan, Sylvan, Wallenstein, Gertrud, Berkowitz, James G, Wetmur   +4 more
openaire   +2 more sources

Paraoxonase 1 in Chronic Kidney Failure [PDF]

Journal of Lipids, 2012
In this review we summarize the findings from the literature and our own laboratory on the decreased PON1 activity in renal failure, the mechanisms proposed and the effect of interventions. In addition to profound alterations in lipoproteins, reduced serum PON1 activity has been clearly established in the past decade and could contribute to accelerated
Alejandro Gugliucci, Kazuhiko Kotani, Satoshi Kimura   +2 more
openaire   +2 more sources

Interactions of Paraoxonase-1 with Pharmacologically Relevant Carbamates [PDF]

Molecules, 2020
Mammalian paraoxonase-1 hydrolyses a very broad spectrum of esters such as certain drugs and xenobiotics. The aim of this study was to determine whether carbamates influence the activity of recombinant PON1 (rePON1). Carbamates were selected having a variety of applications: bambuterol and physostigmine are drugs, carbofuran is used as a pesticide ...
Anita Bosak, Aljoša Bavec, Tilen Konte, Goran Šinko, Zrinka Kovarik, Marko Goličnik   +5 more
openaire   +5 more sources

Relationship of serum paraoxonase 1 activity and paraoxonase 1 genotype to risk of systemic lupus erythematosus [PDF]

Arthritis & Rheumatism, 2006
AbstractObjectiveLow serum paraoxonase 1 (PON1) activity determined with paraoxon as substrate has been found to be associated with coronary artery disease. This study was undertaken to examine the relationship of PON1 activity and genotype to risk of systemic lupus erythematosus (SLE).MethodsThe impact of 7 PON1 single‐nucleotide polymorphisms (SNPs ...
Laura M, Tripi, Susan, Manzi, Qi, Chen, Margaret, Kenney, Penny, Shaw, Amy, Kao, Franklin, Bontempo, Candace, Kammerer, M Ilyas, Kamboh   +8 more
openaire   +2 more sources

The Role of PON1 Variants in Disease Susceptibility in a Turkish Population

Global Medical Genetics, 2020
Paraoxonase 1 (PON1) enzyme plays a major role in antioxidant defense and protects the cells against reactive species. The most common PON1 Q192R and L55M polymorphisms are responsible for a wide variation of PON1 activity, which showed an up to 13-fold ...
Mahmoud Abudayyak, Tuğçe Boran, Rumeysa Tukel, Ezgi Oztas, Gül Özhan   +4 more
doaj   +1 more source

Paraoxonase 1 and Non-Alcoholic Fatty Liver Disease: A Meta-Analysis

Molecules, 2021
Oxidative stress is involved in the pathophysiology of nonalcoholic fatty liver disease (NAFLD). However, reliable biomarkers of NAFLD in relation to oxidative stress are not available.
Kazuhiko Kotani, Jun Watanabe, Kouichi Miura, Alejandro Gugliucci   +3 more
doaj   +1 more source

Correlation of Paraoxonase-1 with the Severity of Crohn’s Disease [PDF]

Molecules, 2018
Diagnostics of Crohn’s disease (CD) requires noninvasive biomarkers facilitating early detection and differentiation of the disease. Therefore, in this study, we aimed to determine the relationship between paraoxonase-1 (PON-1), the severity of CD, oxidative stress, and inflammation in CD.
Katarzyna Szczeklik, Tomasz Mach, Dorota Cibor, Danuta Owczarek, Jacek Sapa, Monika Papież, Jolanta Pytko-Polończyk, Wirginia Krzyściak   +7 more
openaire   +5 more sources

Study of Paraoxonase 1 (PON1) Activity as an Independent Risk Factor in Coronary Artery Disease [PDF]

National Journal of Laboratory Medicine, 2013
Background: Coronary Artery Disease is the major cause of mortality and morbidity worldwide. Human serum paraoxonase-1 is a high density lipoprotein bound enzyme exhibiting antiatherogenic properties.
Sangita M. Patil, Mangesh P. Banker, Ramchandra K. Padalkar, Abhijit P. Pathak, Shital Ghodke, Anjali S. Phatake , Sonali S. Bhagat, Rahul A. Ghone   +7 more
doaj   +1 more source