Results 11 to 20 of about 29,702,919 (206)
Paraoxonase-1 and clopidogrel efficacy [PDF]
Nature Medicine, 2011 Clopidogrel active thiol metabolite is formed through 1) a cytochrome P450 (CYP dependent oxidation to a thiolactone : 2-oxoclopidogrel. Then a second CYP dependent oxidation to a sulfenic acid which is reduced by excess glutathione to the active cis -thiol-acid.
Thomas, Cuisset +5 more
core +10 more sources
The paraoxonase 1, 2 and 3 in humans [PDF]
Biochemia Medica, 2011 The paraoxonase gene family in humans includes three members: PON1, PON2 and PON3. The products of those three genes are the following enzymes: paraoxonase 1 (PON1), paraoxonase 2 (PON2) and paraoxonase 3 (PON3). PON1 is mainly associated with a high density lipoprotein (HDL). A small amount of this enzyme is also bound to very low-density lipoprotein (
Grdic Rajkovic, Marija +2 more
core +11 more sources
Paraoxonase 1 Activity and Survival in Sepsis Patients
Balkan Medical Journal, 2015 Background: Sepsis is a state of augmented oxidative stress and diminished antioxidant capacity. High density lipoprotein (HDL) particles were shown to possess antioxidant and anti-inflammatory properties, as well as Paraoxonase 1 (PON1), which is an ...
Volkan İnal +4 more
doaj +6 more sources
Misconceptions about paraoxonase-1
Brazilian Journal of Otorhinolaryngology, 2022 Michael Mackness, Eser Y. Sozmen
doaj +4 more sources
Genetic polymorphisms of paraoxonase 1 and susceptibility to atherogenesis [PDF]
Srpski Arhiv za Celokupno Lekarstvo, 2013 Introduction. Paraoxonase 1 (PON1) is a multifunctional enzyme associated with high-density lipoprotein particles (HDL). It is a cellular antioxidant that hydrolyses oxidized macromolecules, especially low-density lipoproteins (ox-LDL).
Grubiša Ivana +5 more
doaj +4 more sources
Ascorbic acid partly antagonizes resveratrol mediated heme oxygenase-1 but not paraoxonase-1 induction in cultured hepatocytes - role of the redox-regulated transcription factor Nrf2 [PDF]
BMC Complementary and Alternative Medicine, 2011 Background Both resveratrol and vitamin C (ascorbic acid) are frequently used in complementary and alternative medicine. However, little is known about the underlying mechanisms for potential health benefits of resveratrol and its interactions with ...
Hori Osamu +9 more
doaj +3 more sources
Paraoxonase-1 and Early-Life Environmental Exposures
Annals of Global Health, 2016 Acute and chronic exposures to widely used organophosphorus (OP) insecticides are common. Children's detoxification mechanisms are not well developed until several years after birth.
Judit Marsillach +2 more
doaj +5 more sources
Paraoxonase 1 polymorphisms and survival [PDF]
European Journal of Human Genetics, 2004 The antioxidant enzyme paraoxonase 1 (PON1) has previously been suggested to confer protection against coronary heart disease (CHD), one of the main causes of death in the Western world. Two coding polymorphisms, 55M/L and 192Q/R, and a promoter variant, -107C/T, has been extensively studied with respect to susceptibility to CHD. In this study, we have
Christiansen, Lene +3 more
openaire +2 more sources
Paraoxonase 1 in neurological disorders [PDF]
Redox Report, 2013 Paroxonase 1 displays multiple physiological activities that position it as a putative player in the pathogenesis of neurological disorders. Here we reviewed the literature focusing on the role of paraoxonase 1 (PON1) as a factor in the risk of stroke and the major neurodegenerative diseases.
Teresita, Menini, Alejandro, Gugliucci
openaire +2 more sources
Solubilization and Humanization of Paraoxonase-1 [PDF]
Journal of Lipids, 2012 Paraoxonase-1 (PON1) is a serum protein, the activity of which is related to susceptibility to cardiovascular disease and intoxication by organophosphorus (OP) compounds. It may also be involved in innate immunity, and it is a possible lead molecule in the development of a catalytic bioscavenger of OP pesticides and nerve agents.
Mohosin Sarkar +8 more
openaire +2 more sources