Results 31 to 40 of about 27,544,016 (212)
Interactions of Paraoxonase-1 with Pharmacologically Relevant Carbamates [PDF]
Molecules, 2020 Mammalian paraoxonase-1 hydrolyses a very broad spectrum of esters such as certain drugs and xenobiotics. The aim of this study was to determine whether carbamates influence the activity of recombinant PON1 (rePON1). Carbamates were selected having a variety of applications: bambuterol and physostigmine are drugs, carbofuran is used as a pesticide ...
Anita Bosak +5 more
openaire +5 more sources
Paraoxonase 1 Activity and its Polymorphism in Type 2 Diabetic Nephropathy
Endocrinology Research and Practice, 2018 Objective: This study aims to investigate the role of paraoxonase 1 activity and Q192R polymorphism in the development of nephropathy in patients with Type 2 diabetes mellitus.
Mukund R. MOGAREKAR +2 more
doaj +1 more source
The Effects of Bioavailability-Enhanced Curcuminoids on Serum Paraoxonase-1 Activity in Patients with Metabolic Syndrome [PDF]
Journal of Cardio-Thoracic Medicine, 2021 Introduction: Metabolic syndrome (MetS) is characterised by a clustering of metabolic cardiovascular disease (CVD) risk factors that include: central obesity, impaired glucose metabolism, dyslipidaemia (hypertriglyceridemia, increased low-density ...
Atena Raee +7 more
doaj +1 more source
Paraoxonase 1 in Chronic Kidney Failure [PDF]
Journal of Lipids, 2012 In this review we summarize the findings from the literature and our own laboratory on the decreased PON1 activity in renal failure, the mechanisms proposed and the effect of interventions. In addition to profound alterations in lipoproteins, reduced serum PON1 activity has been clearly established in the past decade and could contribute to accelerated
Alejandro Gugliucci +2 more
openaire +2 more sources
Haplotype-Phenotype Relationships of Paraoxonase-1 [PDF]
Cancer Epidemiology, Biomarkers & Prevention, 2005 Abstract Paraoxonase 1 (PON1) is an enzyme with multiple activities, including detoxification of organophosphates. It is believed to be important in preventing neurotoxic damage and has also been implicated in atherosclerosis. The PON1 gene contains five common polymorphisms, three in the promoter (−909G > C, −162A > G ...
Jia, Chen +4 more
openaire +2 more sources
Serum paraoxonase 1 activity and protein N-homocysteinylation in primary human endometrial cancer
Tumor Biology, 2018 Paraoxonase 1 plays an important role in protection from oxidative stress and also decomposes homocysteine thiolactone, the toxic metabolite of homocysteine.
Krzysztof Gałczyński +5 more
doaj +1 more source
Antioxidants, 2023 The presence of a pro-oxidant state in patients with schizophrenia may account for the increased risk of atherosclerosis and cardiovascular disease in this group and supports the potential utility of circulating biomarkers of oxidative stress for risk ...
Angelo Zinellu +2 more
doaj +1 more source
Relationship of serum paraoxonase 1 activity and paraoxonase 1 genotype to risk of systemic lupus erythematosus [PDF]
Arthritis & Rheumatism, 2006 AbstractObjectiveLow serum paraoxonase 1 (PON1) activity determined with paraoxon as substrate has been found to be associated with coronary artery disease. This study was undertaken to examine the relationship of PON1 activity and genotype to risk of systemic lupus erythematosus (SLE).MethodsThe impact of 7 PON1 single‐nucleotide polymorphisms (SNPs ...
Laura M, Tripi +8 more
openaire +2 more sources
The Role of PON1 Variants in Disease Susceptibility in a Turkish Population
Global Medical Genetics, 2020 Paraoxonase 1 (PON1) enzyme plays a major role in antioxidant defense and protects the cells against reactive species. The most common PON1 Q192R and L55M polymorphisms are responsible for a wide variation of PON1 activity, which showed an up to 13-fold ...
Mahmoud Abudayyak +4 more
doaj +1 more source
Correlation of Paraoxonase-1 with the Severity of Crohn’s Disease [PDF]
Molecules, 2018 Diagnostics of Crohn’s disease (CD) requires noninvasive biomarkers facilitating early detection and differentiation of the disease. Therefore, in this study, we aimed to determine the relationship between paraoxonase-1 (PON-1), the severity of CD, oxidative stress, and inflammation in CD.
Katarzyna Szczeklik +7 more
openaire +5 more sources