Results 31 to 40 of about 16,430 (217)
Decreased paraoxonase-1 activity is associated with alterations of high-density lipoprotein particles in chronic liver impairment [PDF]
, 2010 Background Paraoxonase-1 (PON1), a lactonase synthesized by the liver, circulates in blood bound to high-density lipoproteins (HDL). This enzyme is thought to degrade oxidized phospholipids and play an important role in the organism's antioxidant and ...
Judit Marsillach +9 more
core +2 more sources
Sleepiness, inflammation and oxidative stress markers in middle-aged males with obstructive sleep apnea without metabolic syndrome: a cross-sectional study [PDF]
, 2015 Background: the simultaneous occurrence of metabolic syndrome and excessive daytime sleepiness are very common in obstructive sleep apnea (OSA) patients.
Andaku, Daniela Kuguimoto +5 more
core +2 more sources
Serum paraoxonase-1 activity and risk of incident cardiovascular disease:The PREVEND study and meta-analysis of prospective population studies [PDF]
, 2016 Background: Paraoxonase-1 (PON-1) has been suggested to be associated with cardiovascular disease (CVD) risk, however, aspects of the association, such as shape and independence from conventional risk factors are still uncertain.
Bakker, Stephan J L +3 more
core +2 more sources
Interactions of Paraoxonase-1 with Pharmacologically Relevant Carbamates [PDF]
Molecules, 2020 Mammalian paraoxonase-1 hydrolyses a very broad spectrum of esters such as certain drugs and xenobiotics. The aim of this study was to determine whether carbamates influence the activity of recombinant PON1 (rePON1). Carbamates were selected having a variety of applications: bambuterol and physostigmine are drugs, carbofuran is used as a pesticide ...
Anita Bosak +5 more
openaire +5 more sources
Paraoxonase 1 status in the Thai population [PDF]
Journal of Human Genetics, 2005 Human serum paraoxonase 1 (PON1), a high-density lipoprotein (HDL)-associated enzyme, has been shown to reduce the oxidation of low-density lipoprotein (LDL) and HDL by degrading lipid peroxides. This property of PON1 accounts for its ability to protect against atherosclerosis.
Wimon, Phuntuwate +4 more
openaire +2 more sources
Paraoxonase 1 as an important antiatherogenic agent
Journal of Education, Health and Sport, 2019 The inverse relationship between High Density Lipoproteins (HDL) level and risk of ischaemic heart disease was proved by many epidemiological studies. Although the main mechanism of antiatherogenic activity of HDL is a reverse transport of cholesterol ...
Ewa Lidia Krzewicka-Romaniuk +3 more
doaj +3 more sources
Serum paraoxonase 1 (PON1) measurement: an update [PDF]
BMC Veterinary Research, 2014 Paraoxonase 1 (PON1) is a widely studied enzyme based on its protective role against poisoning by organophosphate (OP) metabolites of specific OP insecticides and in vascular disease, as well as its use as biomarker of diseases involving oxidative stress, inflammation and liver diseases.This review provides an update about the current knowledge in the ...
Ceron, Jose J +2 more
openaire +2 more sources
Regulation of Hepatic Paraoxonase-1 Expression [PDF]
Journal of Lipids, 2012 Serum paraoxonase-1 (PON1) is a member of the paraoxonases family (PON1, PON2, and PON3). PON1 is synthesized and secreted by the liver, and in circulation it is associated with HDL. PON1 has antioxidative properties, which are associated with the enzyme’s capability to decrease oxidative stress in atherosclerotic lesions and to attenuate ...
openaire +2 more sources
A Role of the Bile Salt Receptor FXR in Atherosclerosis [PDF]
, 2010 This study reviews current insights into the role of bile salts and bile salt receptors on the progression and regression of atherosclerosis. Bile salts have emerged as important modifiers of lipid and energy metabolism.
Groen, A.K. +3 more
core +3 more sources
Paraoxonase 1 (PON1) status and substrate hydrolysis [PDF]
Toxicology and Applied Pharmacology, 2009 Paraoxonase 1 (PON1) hydrolyzes a number of organophosphorus (OP) compounds including insecticides and nerve agents. The in vivo efficacy of PON1 to protect against a specific OP exposure depends on the catalytic efficiency of hydrolysis. The Q192R polymorphism affects the catalytic efficiency of hydrolysis of some substrates and not others. While PON1(
Rebecca J, Richter +2 more
openaire +2 more sources