Results 51 to 60 of about 16,430 (217)

Association between pesticide exposure and paraoxonase-1 (PON1) polymorphisms, and neurobehavioural outcomes in children: a systematic review

Systematic Reviews, 2020
Environmental factors such as pollution, pesticide exposure and socio-demographic location have been implicated as a pressure capable of altering genetic make-up.
Nkosinathi Banhela, Pragalathan Naidoo, Saloshni Naidoo   +2 more
doaj   +1 more source

The importance of longitudinal evaluation using DAT‐SPECT in organophosphate‐induced toxic parkinsonism

Psychiatry and Clinical Neurosciences Reports, Volume 5, Issue 2, June 2026.
We performed longitudinal evaluation using magnetic resonance imaging (MRI) and dopamine transporter single‐photon emission computed tomography (DAT‐SPECT) in a case of organophosphate‐induced toxic parkinsonism. Fluid‐attenuated inversion recovery (FLAIR) images showed bilateral striatal hyperintensity in the acute phase, followed by reduction of ...
Shuhei Nakao, Yoichiro Kogoh, Hideki Funahashi, Yusei Yanoma, Minako Azuma, Yasushi Ishida, Yoji Hirano   +6 more
wiley   +1 more source

Paraoxonase-1 is related to inflammation, fibrosis and PPAR delta in experimental liver disease [PDF]

, 2009
Background Paraoxonase-1 (PON1) is an antioxidant enzyme synthesized by the liver. It protects against liver impairment and attenuates the production of the pro-inflammatory monocyte chemoattractant protein-1 (MCP-1).
Judit Marsillach, Jordi Camps, Natàlia Ferré, Raul Beltran, Anna Rull, Bharti Mackness, Michael Mackness, Jorge Joven, M Parola, I Leviev, L Rodrigo, BN La Du, N Ferré, N Ferré, J Marsillach, C Zhang, B Ustundag, KJ Simpson, C Daly, MJ Czaja, J Marsillach, B Coll, JP Iredale, MJ Arthur, W Jiménez, N Ferré, M Gassó, O Khersonsky, L Gaidukov, J Marsillach, AB Goulter, H Chung, R Bataller, KK Kharbanda, K Hensley, M Parola, E Zamara, M Czaja, F Marra, T Tabata, F Marra, E Zamara, M Parola, B Mackness, M Navab, C Fürnsinn, Y Fan, M Pesant, M Cabré, XP Yang, M Karin, M Aviram, M Aviram, B Li   +53 more
core   +2 more sources

The Antipsychotic Aripiprazole Induces Cytotoxicity in Bladder Cancer Cells While Preserving Urothelial and Bladder Function

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
Current bladder cancer therapies can cause toxicity and bladder dysfunction. Brief intravesical‐like aripiprazole exposure reduced bladder cancer cell viability and was associated with redox stress and caspase‐3 activation, while ex vivo findings suggested preserved bladder structure and function, warranting further investigation as a potential ...
Liam A. O'Callaghan, Katie Powell, Russ Chess‐Williams, Catherine McDermott   +3 more
wiley   +1 more source

Paraoxonase-1 and clopidogrel efficacy [PDF]

Nature Medicine, 2011
CAMPS J., JOVEN J., MACKNESS B., MACKNESS M., TAWFIK D., DRAGANOV D., PARAGH G., SERES I., HORKE S., JAMES R., HERNANDEZ A., REDDY S., SHIH D., NAVAB M., ROCHU D., AVIRAM M., COSTA, Lucio Guido   +16 more
  +10 more sources

Effects of high sucrose diet, gemfibrozil, and their combination on plasma paraoxonase 1 activity and lipid levels in rats [PDF]

, 2010
We investigated the influence of high sucrose diet (HSD) after 3 or 5 weeks of administration on paraoxonase 1 (PON1) activity in plasma of normolipidemic rats and the relationship between serum PON1 activity, triacylglycerides (TGs), HDL and total ...
Bradamante, Vlasta, Lucić Vrdoljak, Ana, Macan, Marija, Radić, Božica, Vrkić, Nada   +4 more
core  

Protein glycosylation in lung cancer from a mass spectrometry perspective

Mass Spectrometry Reviews, Volume 45, Issue 3, Page 455-475, May/June 2026.
ABSTRACT Lung cancer is a severe disease for which better diagnostic and therapeutic approaches are urgently needed. Increasing evidence implies that aberrant protein glycosylation plays a crucial role in the pathogenesis and progression of lung cancer.
Mirjam Balbisi, Simon Sugár, Lilla Turiák   +2 more
wiley   +1 more source

Paraoxonase 1 Polymorphism p.Q192R in Patients With Dementia [PDF]

, 2011
PON1 PCR-RFLP polymorphism frequency and enzyme activity were determined in 223 patients with dementia (94 with AD, 55 with VaD and 74 with MD) and in 100 age and sex matched controls without dementia.
Tomasz Krzywkowski
core   +1 more source

Paraoxonase (PON1 and PON3) Polymorphisms: Impact on Liver Expression and Atorvastatin-Lactone Hydrolysis [PDF]

, 2011
Atorvastatin δ-lactone, a major, pharmacologically inactive metabolite, has been associated with toxicity. In a previous study we showed that polymorphisms of UGT1A3 influence atorvastatin δ-lactone formation.
Stephan eRiedmaier, Kathrin eKlein, Stefan eWinter, Ute eHofmann, Matthias eSchwab, Matthias eSchwab, Matthias eSchwab, Ulrich M Zanger   +7 more
core   +2 more sources

The Mitochondrial NAD Transporter SLC25A51 in Adipocytes Regulates Adipose Tissue Mitochondrial Function and Systemic Metabolism During Aging

Aging Cell, Volume 25, Issue 5, May 2026.
We revealed the pathophysiological significance and therapeutic potential of adipocyte mitochondrial NAD transporter, namely solute carrier family 25 member 51 (SLC25A51), in age‐associated metabolic diseases, particularly adipose tissue mitochondrial function, obesity, and insulin resistance, by analyzing adipocyte‐specific Slc25a51 knockout (ASKO ...
Daiki Kojima, Keisuke Yaku, Shotaro Kosugi, Ryunosuke Mitsuno, Kenji Kaneko, Yoshinaga Kawano, Akihito Hishikawa, Seiya Mizuno, Manami Katoh, Akiko Satoh, Shinya Toyokuni, Tatsuhiko Azegami, Kenichiro Kinouchi, Shintaro Yamaguchi, Hiroshi Itoh, Takeshi Kanda, Toshimasa Yamauchi, Takashi Nakagawa, Kaori Hayashi, Jun Yoshino   +19 more
wiley   +1 more source