Results 61 to 70 of about 29,702,919 (206)

Quinoline and Phthalimide Substituted Silicon Phthalocyanines as Multi‐Target Inhibitors of Cholinesterases and Carbonic Anhydrases

open access: yesJournal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.
Two novel axially substituted silicon phthalocyanines were synthesized and characterized. Compound 2a exhibited significantly enhanced inhibition of AChE, BChE, hCA I and hCA II, supported by molecular docking and SAR analysis, highlighting its potential as a multifunctional enzyme inhibitor with promising biological activity.
Seda Ünlü   +3 more
wiley   +1 more source

The Potential Importance of Paraoxonase-1 in Surgical Patients [PDF]

open access: yesJournal of Investigative Surgery, 2019
In recent years, the understanding of surgical stress has been expanded due to increased research interest, mainly driven by the introduction of novel biomarkers and innovative surgical techniques....
Vekić, Jelena   +1 more
openaire   +4 more sources

Relationship of paraoxonase-1 and paraoxonase-3 with routine laboratory tests and oxidative stress in type 2 diabetes mellitus

open access: yesTürk Biyokimya Dergisi
We aimed to investigate the relationship between serum paraoxonase-1 (PON1) and paraoxonase-3 (PON3) levels and activities with hemoglobin A1c (HbA1c), serum fasting blood glucose, lipid profile, and oxidative stress in patients with type 2 diabetes ...
Ucar Yagcı Yagmur   +3 more
doaj   +1 more source

Therapeutic Potential of Chickpea‐Derived Bioactives: A Review With Perspective of Different In Vitro, Animal, and Human Studies

open access: yesLegume Science, Volume 8, Issue 3, September 2026.
ABSTRACT Chickpea (Cicer arietinum L.) is an important dietary legume worldwide and provides micronutrients and phytochemicals, including phenolics, flavonoids, carotenoids, bioactive peptides, dietary fiber, and resistant starch. This narrative review summarizes evidence from in vitro, animal, and human studies on the potential health relevance of ...
Rohama Shahid   +4 more
wiley   +1 more source

Paraoxonase-1 activities in children and adolescents with type 1 diabetes mellitus [PDF]

open access: yes, 2016
Background: Paraoxonase-1 is an HDL-associated esterase that acts as an anti-atherogenic agent by protecting LDL from oxidation. This study investigates paraoxonase-1 activities in children and adolescents with type 1 diabetes mellitus and possible ...
Cret, Victoria   +5 more
core   +1 more source

Effect of four weeks of endurance training on serum level of paraoxonase-1 and lipid profile in non-athlete obese men

open access: yesمجله دانشگاه علوم پزشکی گرگان, 2014
Background and Objective: Paraoxonase-1 is an important factor in preventing lipid oxidation and formation of oxidized low-density lipoprotein. There are conflicting reports on the impact of physical activity on serum level of Paraoxonase-1.
Amouzad Mahdirejei T   +3 more
doaj  

The Effect of Atherogenic Diet with or without Enzyme Inhibitors on the Incidence and Progress of Atherosclerosis in Rabbits [PDF]

open access: yesJournal of Cardiovascular and Thoracic Research, 2011
PON1 (Paraoxonase – 1) is an esterase enzyme which is associated with high density lipoprotein (HDL). The enzyme prevents the peroxidation of low density lipoprotein (LDL).
Masouad Pezeshkian   +6 more
doaj  

Neuroprotective Role of E3 Ubiquitin Ligase TRIM2 in Parkinson's Disease: Attenuation of Oxidative Stress and Apoptosis via Promoting ELAVL1 Ubiquitination

open access: yesCNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.
The E3 ubiquitin ligase TRIM2 confers neuroprotection against 6‐OHDA‐induced oxidative stress and apoptosis. It exerts this function by binding to ELAVL1 and promoting its degradation via the ubiquitin‐proteasome pathway. Thus, our study reveals the TRIM2‐ELAVL1 axis as a key regulatory mechanism for neuronal survival under 6‐OHDA‐stimulated toxic ...
Wei Liang   +4 more
wiley   +1 more source

Evaluation of paraoxonase, malondialdehyde, and lipoprotein levels in patients with asymptomatic cholelithiasis

open access: yesThe Saudi Journal of Gastroenterology, 2014
Background/Aim: To compare lipoprotein and malondialdehyde levels and paraoxonase-1 activity between subjects with asymptomatic cholelithiasis and controls.
Aytac Atamer   +3 more
doaj   +1 more source

The characterization of a new stabilized lactonase from the endophytic fungi Aspergillus pseudonomiae with anti‐bacterial and anti‐fungal properties

open access: yesProtein Science, Volume 35, Issue 8, August 2026.
Abstract Microorganisms use diverse small‐molecule signals to coordinate behavior, supporting interspecies and interkingdom communication. These chemical dialogs shape fundamental biological processes and define interactions from cooperation to antagonism.
Dor Ben Tovim   +4 more
wiley   +1 more source

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